Suppressed TGF-?1 expression is correlated with up-regulation of matrix metalloproteinase-13 in keloid regression after flashlamp pulsed-dye laser treatment

Kuo, Yur-Ren; Wu, Wei-Jian; Jeng, Seng‐Feng; Wang, Feng‐Sheng; Huang, Hsin‐Chun; Lin, Cha-Zon; Yang, Kuender D.

doi:10.1002/lsm.20104

Cited by 89 publications

(58 citation statements)

References 40 publications

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“…MMP1 is called collagenase and its main substrate are collagen type III, I, II, VII, and X. Although it is well established that MMP expression was increased in damaged or photoaged skin [38,39], Cuerda-Galindo observed MMP-1 increased following IPL irradiation, consistent with the previous findings induced by laser treatment [40,41]. Based on the above theories, these authors speculate that increased MMP could be an overlooked mechanism of skin rejuvenation, in which it will be implicated, contributing to the degradation of senescent collagens and then the turnover of the ECM [35].…”

Section: In Vitro Effects Of Ipl On Fibroblasts Cytokines Etcsupporting

confidence: 81%

Intense Pulsed Light Therapy

Gu¹,

Liu²,

Liu³

2017

Photomedicine - Advances in Clinical Practice

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Intense pulsed light (IPL) is one of the most effective nonablative approaches to treat skin photoaging. The broad range of wavelengths (500-1200 nm) emitted from IPL devices effectively target both melanin and hemoglobin in the skin. Numerous trials show the effectiveness and compatibility of IPL devices in a variety of skin conditions, especially in cosmetic indications such as hypertrichosis and telangiectasias. Compared with the wide clinical use of IPL, the biochemical and molecular mechanism is not clear. Both in vivo and in vitro studies demonstrate that IPL could increase the production of extracellular matrix, promote the proliferation of fibroblasts, and increase the secretion of TGF-β and matrix metalloproteinases, which play important roles in the photorejuvenation effects of IPL. However, investigations regarding the detailed underlying mechanism are necessary.

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Section: In Vitro Effects Of Ipl On Fibroblasts Cytokines Etcsupporting

confidence: 81%

Intense Pulsed Light Therapy

Gu¹,

Liu²,

Liu³

2017

Photomedicine - Advances in Clinical Practice

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“…7(a) and 7(e). This finding may be due to the long half-life of collagen degradation in keloid [40] and the short observation period (up to 11 months) in the present study.…”

Section: Discussionmentioning

confidence: 65%

Non-invasive evaluation of therapeutic response in keloid scar using diffuse reflectance spectroscopy

Hsu

Tzeng

Yang

et al. 2015

Biomed. Opt. Express

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Abstract:The pathogenesis and ideal treatment of keloid are still largely unknown, and it is essential to develop an objective assessment of keloid severity to evaluate the therapeutic response. We previously reported that our diffuse reflectance spectroscopy (DRS) system could assist clinicians in understanding the functional and structural condition of keloid scars. The purpose of this study was to understand clinical applicability of our DRS system on evaluating the scar severity and therapeutic response of keloid. We analyzed 228 spectral data from 71 subjects with keloid scars. The scars were classified into mild (0-3), moderate (4-7) and severe (8-11) according to the Vancouver scar scale. We found that as the severity of the scar increased, collagen concentration and water content increased, and the reduced scattering coefficient at 800 nm and oxygen saturation (SaO 2 ) decreased. Using the DRS system, we found that collagen bundles aligned in a specific direction in keloid scars, but not in normal scars. Water content and SaO 2 may be utilized as reliable parameters for evaluating the therapeutic response of keloid. In conclusion, the results obtained here suggest that the DRS has potential as an objective technique with which to evaluate keloid scar severity. In addition, it may be useful as a tool with which to track longitudinal response of scars in response to various therapeutic interventions.

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“…Metaloproteinazy macierzy pozakomórkowej i ich substraty [39][40][41] TIMP-2, TIMP-3, TIMP-4) i niespecyficznych inhibitorów (α2-makroglobuliny, α1-antytrypsyny, inhibitora plazminogenu 1) [45][46][47][48][49][50][51][52][53][54]. Szczególne znaczenie w formowaniu keloidów mają kolagenaza 1 (MMP-1) i żelatynazy (MMP-2 i MMP-9).…”

Section: Czynnik Wzrostu Tkanki łąCznejunclassified

Review papers Some molecular aspects of the fibroproliferative process in keloids

Antończak¹,

Jurzak²,

Adamczyk³

et al. 2015

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StreSzczenieProcesy naprawcze (reperatywne) uszkodzonych tkanek należą do podstawowych procesów biologicznych zapewniających utrzymanie homeostazy organizmu. Zasadniczo obejmują fazę zapalną, proliferacyjną oraz przebudowy. Końcowym efektem gojenia się uszkodzonych tkanek jest powstanie blizny. Nieprawidłowości w przebiegu gojenia się ran mogą być przyczyną tworzenia keloidów (bliznowców). W patofizjologii keloidów obserwuje się zarówno nieprawidłowości w migracji, proliferacji i apoptozie komórek, jak i w syntezie oraz sekrecji białek, cytokin, enzymów proteolitycznych degradujących składniki macierzy pozakomórkowej, a także ich inhibitorów. Dotychczasowo stosowane terapie nie przynoszą zadowalających efektów kosmetycznych. Obecnie prowadzone badania skupiają się na poszukiwaniu metod bezpośredniego hamowania procesu fibroproliferacyjnego poprzez modulowanie ekspresji cytokin, hamowanie proliferacji fibroblastów oraz regulowanie biosyntezy i degradacji składników macierzy pozakomórkowej. AbStrActReparation of damaged tissues is an essential biological process that ensures maintenance of homeostasis. Basically it includes phases of inflammation, proliferation and remodeling. The result of healing of damaged tissues is scar formation. Abnormalities in the course of wound healing may lead to keloid formation. The pathophysiology of keloids is characterized by improper migration, proliferation and apoptosis of cells as well as imbalanced synthesis and secretion of proteins, cytokines, proteolytic enzymes and their inhibitors. To date, applied therapeutic methods do not lead to satisfactory cosmetic results of the treatment. Current research focuses on developing methods for direct inhibition of the fibroproliferative process, mainly through modulation of cytokine expression and in consequence suppression of fibroblast proliferation and balancing of synthesis and degradation of extracellular matrix components.

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Suppressed TGF-?1 expression is correlated with up-regulation of matrix metalloproteinase-13 in keloid regression after flashlamp pulsed-dye laser treatment

Abstract: Regression of keloids regressed after PDL treatments are associated with down-regulation of TGF-beta1 expression and up-regulation of MMP-13 activity.

Cited by 89 publications

References 40 publications

Intense Pulsed Light Therapy

Intense Pulsed Light Therapy

Non-invasive evaluation of therapeutic response in keloid scar using diffuse reflectance spectroscopy

Review papers Some molecular aspects of the fibroproliferative process in keloids

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