Support Ellagic Acid Therapy in Patients with Hormone Refractory Prostate Cancer (HRPC) on Standard Chemotherapy Using Vinorelbine and Estramustine Phosphate

Falsaperla, Mario; Morgia, Giuseppe; Tartarone, Alfredo; Ardito, Raffaele; Romano, Giampiero

doi:10.1016/j.eururo.2004.12.001

Cited by 96 publications

(68 citation statements)

References 27 publications

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“…For example, ellagic acid polyphenol reduced chemotherapy induced toxicity in a phase II trial in hormone refractory prostate cancer. 75 Vitamin E enhanced the chemotherapeutic effect of adriamycin in prostate cancer cells. 76 Antagonists/therapies that target Snail signaling.…”

Section: Therapies Targeting Snailmentioning

confidence: 99%

The role of Snail in prostate cancer

Smith

Odero-Marah²

2012

Cell Adhesion & Migration

103

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hairpin RNA; VEGF-A, vascular endothelial growth factor-A; NRP1, neuropilin-1; GDF-9, growth and differentiation factor 9; HIF-1a, hypoxia inducible factor 1 a; ERβ1, estrogen receptor β-1; NED, neuroendocrine differentiation; RANKL, receptor activator of NFkB ligand; ROS, reactive oxygen species; GA, gambogic acid; EGCG, epigallocatechin-3-gallate; PTL, sesquiterpene lactone parthenolideProstate cancer is the second most frequently diagnosed cancer and the sixth leading cause of death from cancer in men. Epithelial-mesenchymal transition (EMT) is a process by which cancer cells invade and migrate, and is characterized by loss of cell-cell adhesion molecules such as E-cadherin and increased expression of mesenchymal proteins such as vimentin; EMT is also associated with resistance to therapy. Snail, a master regulator of EMT, has been extensively studied and reported in cancers such as breast and colon; however, its role in prostate cancer is not as widely reported. The purpose of this review is to put together recent facts that summarize Snail signaling in human prostate cancer. Snail is overexpressed in prostate cancer and its expression and activity is controlled via phosphorylation and growth factor signaling. Snail is involved in its canonical role of inducing EMT in prostate cancer cells; however, it plays a role in non-canonical pathways that do not involve EMT such regulation of bone turnover and neuroendocrine differentiation. Thus, studies indicate that Snail signaling contributes to prostate cancer progression and metastasis and therapeutic targeting of Snail in prostate cancer holds promise in future.

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Section: Therapies Targeting Snailmentioning

confidence: 99%

The role of Snail in prostate cancer

Smith

Odero-Marah²

2012

Cell Adhesion & Migration

103

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“…Over the last few years, a number of in vivo and in vitro studies have provided evidence of important pharmacological properties including antioxidant, anti-inflammatory [7,8,9,10,11] and anticarcinogenic activities [12,13,14].…”

Section: Introductionmentioning

confidence: 99%

Protective effect of ellagic acid, a natural polyphenolic compound, in a murine model of Crohn's disease

Rosillo

Sánchéz-Hidalgo

Cárdeno

et al. 2011

Biochemical Pharmacology

149

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.Page 1 of 37A c c e p t e d M a n u s c r i p t

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“…9 Many in vitro and in vivo investigations established the promising effects of EA, such as antiproliferative drug to arrest the carcinogenesis, direct killer of cancer cells (antitumorigenic), and inhibitor of angiogenesis and metastasis. [10][11][12][13][14][15][16][17] Nonetheless, its therapeutic effect is associated with selective cytotoxicity to carcinoma cells with no harm to normal healthy cells. [10][11][12] Therapeutically, EA has been proclaimed to be effective in the regression of various kinds of tumors, involving but not limited to lung cancer, colorectal carcinoma, esophageal cancer, metastatic melanoma, hepatocellular carcinoma, tongue cancer, breast cancer, bladder cancer, endometrial carcinoma, and prostate cancer.…”

Section: Introductionmentioning

confidence: 99%

Enhanced anticancer activity and oral bioavailability of ellagic acid through encapsulation in biodegradable polymeric nanoparticles

Mady¹,

Shaker²

2017

IJN

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Despite the fact that various studies have investigated the clinical relevance of ellagic acid (EA) as a naturally existing bioactive substance in cancer therapy, little has been reported regarding the efficient strategy for improving its oral bioavailability. In this study, we report the formulation of EA-loaded nanoparticles (EA-NPs) to find a way to enhance its bioactivity as well as bioavailability after oral administration. Poly(ε-caprolactone) (PCL) was selected as the biodegradable polymer for the formulation of EA-NPs through the emulsion–diffusion–evaporation technique. The obtained NPs have been characterized by measuring particle size, zeta potential, Fourier transform infrared, differential scanning calorimetry, and X-ray diffraction. The entrapment efficiency and the release profile of EA was also determined. In vitro cellular uptake and cytotoxicity of the obtained NPs were evaluated using Caco-2 and HCT-116 cell lines, respectively. Moreover, in vivo study has been performed to measure the oral bioavailability of EA-NPs compared to free EA, using New Zealand white rabbits. NPs with distinct shape were obtained with high entrapment and loading efficiencies. Diffusion-driven release profile of EA from the prepared NPs was determined. EA-NP-treated HCT-116 cells showed relatively lower cell viability compared to free EA-treated cells. Fluorometric imaging revealed the cellular uptake and efficient localization of EA-NPs in the nuclear region of Caco-2 cells. In vivo testing revealed that the oral administration of EA-NPs produced a 3.6 times increase in the area under the curve compared to that of EA. From these results, it can be concluded that incorporation of EA into PCL as NPs enhances its oral bioavailability and activity.

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Support Ellagic Acid Therapy in Patients with Hormone Refractory Prostate Cancer (HRPC) on Standard Chemotherapy Using Vinorelbine and Estramustine Phosphate

Cited by 96 publications

References 27 publications

The role of Snail in prostate cancer

The role of Snail in prostate cancer

Protective effect of ellagic acid, a natural polyphenolic compound, in a murine model of Crohn's disease

Enhanced anticancer activity and oral bioavailability of ellagic acid through encapsulation in biodegradable polymeric nanoparticles

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