Supply of corneal tissue in the United Kingdom.

Armitage, W. John; Moss, S.J.; Easty, D L; Ba, Bradley

doi:10.1136/bjo.74.11.685

Cited by 16 publications

(10 citation statements)

References 3 publications

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“…Cadaver corneal tissue for transplantation must meet stringent guidelines for acceptability that include the serological tests and medical history of the donor (52)(53)(54). However, many potential donor corneas, often from elderly donors, are rejected for transplantation because of the lower endothelial cells count and possible age-related diseases.…”

Section: A Growing Demand For Corneal Transplantationmentioning

confidence: 99%

Human Corneal Endothelial Cell Expansion for Corneal Endothelium Transplantation: An Overview

Peh

Beuerman²,

Colman³

et al. 2011

Transplantation

219

224

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The monolayer of cells forming the human corneal endothelium is critical to the maintenance of corneal transparency and is not known to regenerate in vivo. Thus, dysfunction of these cells constitutes the most often cited reasons for the 150,000 or so corneal transplants performed yearly. Although current corneal transplantation is more than 90% successful at 1 year, longer term results are not as encouraging with approximately 70% success at 5 years. Nonimmunologic graft failure and allograft endothelial rejection are the main problems. Furthermore, the global shortage of donor corneas greatly restricts several corneal transplantations performed. With advances in understanding corneal endothelial cell biology, it is now possible to cultivate human corneal endothelial cells (HCECs) in vitro, thus providing new opportunities to develop novel tissue-engineered human corneal endothelium. This review will provide an overview of (a) the characteristics of human corneal endothelium; (b) past and present HCECs isolation and culture protocols; (c) various potential carriers for the generation of tissue-engineered corneal endothelium, together with some of the functional studies reported in various animal models; and (d) the current rapid advancements in surgical techniques for keratoplasty. A successful combination of tissue-engineered human corneal endothelium coupled with innovative and groundbreaking surgical procedures will bridge basic research involving cultured HCECs, bringing it from bench to bedside.

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Section: A Growing Demand For Corneal Transplantationmentioning

confidence: 99%

Human Corneal Endothelial Cell Expansion for Corneal Endothelium Transplantation: An Overview

Peh

Beuerman²,

Colman³

et al. 2011

Transplantation

219

224

View full text Add to dashboard Cite

show abstract

“…No período do levantamento, nosso doador mais idoso tinha 102 anos. A idade avançada costuma ser um fator limitante já que a maioria dos cirurgiões prefere não utilizar cór-neas de pacientes acima de 75 anos (4,(7)(8)(9) . Essa idade é arbitrária, uma vez que a idade do doador não parece estar relacionada com a sobrevivência do enxerto (7) .…”

Section: Processamento Dos Tecidosunclassified

“…Essa idade é arbitrária, uma vez que a idade do doador não parece estar relacionada com a sobrevivência do enxerto (7) . Deve-se reavaliar este aspecto, uma vez que a sobrevida da população está aumentando e a não utilização dos tecidos baseada apenas na idade, pode gerar aumento significativo no descarte de tecidos (5,8) . Por outro lado, doadores idosos podem apresentar história de cirurgia intra-ocular prévia e doenças corneanas, como a guttata, condições que poderiam limitar o uso de córneas em transplantes.…”

Section: Processamento Dos Tecidosunclassified

“…Já os doadores mais jovens costumam apresentar as mais altas densidades endoteliais, o que pode ter contribuído para maior porcentagem de córneas classificadas como excelentes e boas neste grupo. Armitage e cols encontraram correlação significativa entre a idade avançada e menor densidade endotelial (8) . Entretanto, num outro estudo não se observou diferença significativa na contagem de células endoteliais com o aumento da idade (5) .…”

Section: Processamento Dos Tecidosunclassified

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Dez anos de doação de córneas no Banco de Olhos do Hospital São Paulo: perfil dos doadores de 1996 a 2005

Adán¹,

Diniz²,

Perlatto³

et al. 2008

Arq. Bras. Oftalmol.

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“…Corneal graft surgery has seen enormous changes since its birth over 100 years ago,1 including improvements in the processing and storage of corneal tissue in eye banks,2 3 more effective treatment of endothelial rejection and the introduction of lamellar surgical techniques 4–7. The prevalence of corneal disease may also have altered over time—for example, changes in the prevalence of pseudophakic bullous keratopathy requiring keratoplasty8–11 following the introduction and refinement of phacoemulsification cataract surgery 12.…”

Section: Introductionmentioning

confidence: 99%