Supplementation with Vitis vinifera L. skin extract improves insulin resistance and prevents hepatic lipid accumulation and steatosis in high-fat diet–fed mice

Santos, Izabelle Barcellos; de, Graziele Freitas; Cordeiro, Viviane Silva Cristino; Costa, Cristiane Aguiar da; Carvalho, Lenize Costa Reis Marins de; Rocha, Ana Paula Machado da; Costa, G; Ognibene, Dayane Teixeira; Moura, Roberto Soares de; Resende, Ângela Castro

doi:10.1016/j.nutres.2017.05.007

Cited by 16 publications

(9 citation statements)

References 50 publications

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“…Among them is modulation of the activities of ligand-dependent transcription factors, namely, peroxisome Functional food ingredients and obesity Natural Product Communications Vol. 13 (8) 2018 1077 Prevention of hepatic lipid accumulation, improvement in hyperglycemia and insulin resistance (mouse model studies) [86], [87] proliferator-activated receptors (PPARs). Because PPARs are dietary lipid sensors that control energy homeostasis, daily eating of these terpenoids might be useful for the management for obesityinduced metabolic disorders, such as type 2 diabetes, hyperlipidemia, insulin resistance, and cardiovascular diseases [61,96,99].…”

Section: Secondary Plant Metabolitesmentioning

confidence: 99%

Secondary Metabolites, Dietary Fiber and Conjugated Fatty Acids as Functional Food Ingredients against Overweight and Obesity

Kasprzak

Wojtunik-Kulesza

Oniszczuk

et al. 2018

Natural Product Communications

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Obesity is a common serious health problem leading to many serious health disorders. This phenomenon is defined as the over-storage of lipids in adipose tissue that occurs when there is an imbalance between the energy intake and energy used. During obesity, many metabolic alterations occur that can damage several organs, such as vascular or skeletal muscle resulting in the dysfunction of these tissues. In this review, we will discuss molecular genetics and causes of obesity, some of the disorders related to human obesity as well as anti-obesity tool. An interesting solution to the obesity problem is natural substances, revealing anti-obesity activity, as well as functional food enriched with aforementioned substances. Functional foods are products exhibiting a potentially positive effect on health beyond basic nutrition. They contain well-known biologically active natural compounds, which promote optimal health and reduce the risk of many diseases, including obesity.

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Section: Secondary Plant Metabolitesmentioning

confidence: 99%

Secondary Metabolites, Dietary Fiber and Conjugated Fatty Acids as Functional Food Ingredients against Overweight and Obesity

Kasprzak

Wojtunik-Kulesza

Oniszczuk

et al. 2018

Natural Product Communications

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“…It is surprising that hepatic IR knockout mice are characterized by liver, muscle, and adipose tissue insulin resistance, as well as fasting and postprandial hyperglycemia (Perseghin, 2009). Further research has confirmed that hepatic lipid accumulation is responsible for hepatic insulin resistance and whole-body insulin resistance (Ye et al, 2016; Sabater et al, 2017; Santos et al, 2017). Furthermore, Lee et al (2015) have discovered that obese adolescents with fatty liver have a higher risk of systemic insulin resistance than obese adolescents with normal liver.…”

Section: The Liver Is the First Organ To Develop Insulin Resistancementioning

confidence: 95%

Mitophagy in Hepatic Insulin Resistance: Therapeutic Potential and Concerns

Nie

Huang

et al. 2019

Front. Pharmacol.

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Metabolic syndrome, characterized by central obesity, hypertension, and hyperlipidemia, increases the morbidity and mortality of cardiovascular disease, type 2 diabetes, nonalcoholic fatty liver disease, and other metabolic diseases. It is well known that insulin resistance, especially hepatic insulin resistance, is a risk factor for metabolic syndrome. Current research has shown that hepatic fatty acid accumulation can cause hepatic insulin resistance through increased gluconeogenesis, lipogenesis, chronic inflammation, oxidative stress and endoplasmic reticulum stress, and impaired insulin signal pathway. Mitochondria are the major sites of fatty acid β-oxidation, which is the major degradation mechanism of fatty acids. Mitochondrial dysfunction has been shown to be involved in the development of hepatic fatty acid–induced hepatic insulin resistance. Mitochondrial autophagy (mitophagy), a catabolic process, selectively degrades damaged mitochondria to reverse mitochondrial dysfunction and preserve mitochondrial dynamics and function. Therefore, mitophagy can promote mitochondrial fatty acid oxidation to inhibit hepatic fatty acid accumulation and improve hepatic insulin resistance. Here, we review advances in our understanding of the relationship between mitophagy and hepatic insulin resistance. Additionally, we also highlight the potential value of mitophagy in the treatment of hepatic insulin resistance and metabolic syndrome.

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“…Even though the authors did not report any chromatographic identification of phenolic compounds, it has been reported that peanut peel is rich in procyanidins, to which the effects, as mentioned earlier, might be attributed. Peel extracts of Vitis vinifera L. rich in peonidin-3-O-glucoside, petunidin-3-O-glucoside, malvidin-3-O-glucoside, and malvidin-3-(6-O-trans-p-coumaryl)-5-O-diglicoside were proven to improve metabolic syndrome factors in high-fat diet-fed C57BL/6 male mice [15]. In this sense, the research by Santos, de Bem, Cordeiro, da Costa, de Carvalho, da Rocha, da Costa, Ognibene, de Moura, and Resende [15] incorporated 200 mg/kg of grape peel extracts orally administered to mice for 12 weeks.…”

Section: Anti-obesity and Anti-diabeticmentioning

confidence: 99%

“…Peel extracts of Vitis vinifera L. rich in peonidin-3-O-glucoside, petunidin-3-O-glucoside, malvidin-3-O-glucoside, and malvidin-3-(6-O-trans-p-coumaryl)-5-O-diglicoside were proven to improve metabolic syndrome factors in high-fat diet-fed C57BL/6 male mice [15]. In this sense, the research by Santos, de Bem, Cordeiro, da Costa, de Carvalho, da Rocha, da Costa, Ognibene, de Moura, and Resende [15] incorporated 200 mg/kg of grape peel extracts orally administered to mice for 12 weeks. In contrast to non-treated mice, peel extracts prevented both the development of hyperglycemia and increased insulin levels during the treatment.…”

Section: Anti-obesity and Anti-diabeticmentioning

confidence: 99%

Antioxidant Molecules from Plant Waste: Extraction Techniques and Biological Properties

et al. 2020

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The fruit, vegetable, legume, and cereal industries generate many wastes, representing an environmental pollution problem. However, these wastes are a rich source of antioxidant molecules such as terpenes, phenolic compounds, phytosterols, and bioactive peptides with potential applications mainly in the food and pharmaceutical industries, and they exhibit multiple biological properties including antidiabetic, anti-obesity, antihypertensive, anticancer, and antibacterial properties. The aforementioned has increased studies on the recovery of antioxidant compounds using green technologies to value plant waste, since they represent more efficient and sustainable processes. In this review, the main antioxidant molecules from plants are briefly described and the advantages and disadvantages of the use of conventional and green extraction technologies used for the recovery and optimization of the yield of antioxidant naturals are detailed; finally, recent studies on biological properties of antioxidant molecules extracted from plant waste are presented here.

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Supplementation with Vitis vinifera L. skin extract improves insulin resistance and prevents hepatic lipid accumulation and steatosis in high-fat diet–fed mice

Cited by 16 publications

References 50 publications

Secondary Metabolites, Dietary Fiber and Conjugated Fatty Acids as Functional Food Ingredients against Overweight and Obesity

Secondary Metabolites, Dietary Fiber and Conjugated Fatty Acids as Functional Food Ingredients against Overweight and Obesity

Mitophagy in Hepatic Insulin Resistance: Therapeutic Potential and Concerns

Antioxidant Molecules from Plant Waste: Extraction Techniques and Biological Properties

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