Supplementation with different teas from Camellia sinensis prevents memory deficits and hippocampus oxidative stress in ischemia-reperfusion

Abstract

Memory and cognition impairments resultant of ischemic stroke could be minimized or avoided by antioxidant supplementation. In this regard, the neuroprotective potential of Green tea from Camellia sinensis has been investigated. However, there is a lack of information regarding the neuroprotective potential of others teas processed from the Camellia sinensis. Here we investigate the neuroprotective role of green, red, white and black tea on memory deficits and brain oxidative stress in a model of ischemic stroke in rats. Our findings show that green and red teas prevent deficits in object and social recognition memories, but only green tea protects against deficits in spatial memory and avoids hippocampal oxidative status and intense necrosis and others alterations in the brain tissue. In summary, green tea shows better neuroprotection in ischemic stroke than the others teas from Camellia sinensis.

Effects and Mechanisms of Tea and Its Bioactive Compounds for the Prevention and Treatment of Cardiovascular Diseases: An Updated Review

“…Studies on ischemia/reperfusion have indicated the protective role of tea extract against ischemia/reperfusion related injuries [52,53]. A polyphenol trimer from green tea, cinnamon, and resveratrol were found effective in decreasing mitochondrial reactive oxygen species (ROS) and cell swelling in endothelial cells suffering from ischemic injury [52].…”

“…A polyphenol trimer from green tea, cinnamon, and resveratrol were found effective in decreasing mitochondrial reactive oxygen species (ROS) and cell swelling in endothelial cells suffering from ischemic injury [52]. In addition, green tea showed a stronger effect than other teas against ischemia/reperfusion in male Wistar rats [53]. In another study, EGCG in combination with zinc could inhibit hypoxia/reoxygenation-induced cell apoptosis through activating the phosphatidylinositol-3-kinase (PI3K)/RAC-α serine/threonine-protein kinase (Akt) signaling pathway in H9c2 rat cardiac myoblast cells [54].…”

Green Tea and Red Tea from Camellia sinensis Partially Prevented the Motor Deficits and Striatal Oxidative Damage Induced by Hemorrhagic Stroke in Rats

“…The administration of tea from Camellia sinensis and EGCG (the main component of green tea) has already been described as neuroprotective by its antioxidant effects in different models of brain injury [ 9 , 28 ]. A recent study conducted in our laboratory that sought to evaluate the neuroprotective capacity of 4 teas from Camellia sinensis (green, red, white, and black) in an ischemic stroke model showed that the greatest protective effect on memory and oxidative stress is from green tea and red tea, since the best effects associated with green tea [ 11 ]. In another study using green, red, and black teas from Camellia sinensis , Schimidt and colleagues suggest that supplementation with green tea and red tea may avoid deficits in social and object recognition memories related to Alzheimer's disease, but only green tea avoids the hippocampal oxidative stress and damage induced in Alzheimer model [ 16 ].…”

“…In this sense, interventions with potential antioxidants are being studied for treatment of damage caused by redox imbalance in brain tissues [ 9 ]. Antioxidants from natural products can slow or reverse the damage caused by excessive ROS production, as demonstrated in other models of neurodegenerative diseases related to oxidative damage [ 10 , 11 ]. Several studies have shown the efficacy of the treatment with teas from Camellia sinensis as an antioxidant strategy [ 11 , 12 ].…”

“…Recent studies comparing the therapeutic potential of the different teas of Camellia sinensis to protect from memory deficits in ischemia reperfusion (IR) [ 11 ] and in an Alzheimer disease model [ 16 ] have shown that, in addition to green tea, red tea also exerts an effective neuroprotection in these models. Other study performed by our team has already demonstrated the neuroprotective effect of green tea in ICH models [ 12 ]; however, comparative effects between the two teas were not analyzed in this model.…”