Supplementation with Bifidobacterium longum Bar33 and Lactobacillus helveticus Bar13 mixture improves immunity in elderly humans (over 75 years) and aged mice

Finamore, Alberto; Roselli, Marianna; Donini, Lorenzo Maria; Brasili, Elisa; Rami, Rita; Carnevali, Paola; Mistura, Lorenza; Pinto, Alessandro; Giusti, Anna Maria; Mengheri, Elena

doi:10.1016/j.nut.2019.02.005

Cited by 46 publications

(51 citation statements)

References 65 publications

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“…A proper suggestion for maintaining a healthy gut microbiota during the ketogenic diet may be the use of pre and probiotics: Increasing evidences [96,97] demonstrate their positive benefits. The major source of prebiotics is represented by fructo-oligosaccharides, inulin, lactulose galacto-oligosaccharides and trans-galacto-oligosaccharides [98].…”

Section: Discussionmentioning

confidence: 99%

Ketogenic Diet and Microbiota: Friends or Enemies?

Paoli

Mancin

Bianco

et al. 2019

Genes

196

129

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Over the last years, a growing body of evidence suggests that gut microbial communities play a fundamental role in many aspects of human health and diseases. The gut microbiota is a very dynamic entity influenced by environment and nutritional behaviors. Considering the influence of such a microbial community on human health and its multiple mechanisms of action as the production of bioactive compounds, pathogens protection, energy homeostasis, nutrients metabolism and regulation of immunity, establishing the influences of different nutritional approach is of pivotal importance. The very low carbohydrate ketogenic diet is a very popular dietary approach used for different aims: from weight loss to neurological diseases. The aim of this review is to dissect the complex interactions between ketogenic diet and gut microbiota and how this large network may influence human health.

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Section: Discussionmentioning

confidence: 99%

Ketogenic Diet and Microbiota: Friends or Enemies?

Paoli

Mancin

Bianco

et al. 2019

Genes

196

129

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“…Studies have been carried out to alter the composition of the gut microbiota -using probiotics -and to assess the possible role of such treatment in ameliorating gut immunity in aged mice and humans (Finamore et al, 2019;Nyangale et al, 2015). Treating aged mice with specific bacterial components has been found to restore the development of various important immune cells and to improve the inflammatory status (Zakostelska et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

“…Treating aged mice with specific bacterial components has been found to restore the development of various important immune cells and to improve the inflammatory status (Zakostelska et al, 2011). Bifidobacterium longum Bar33 and Lactobacillus helveticus Bar13 probiotic mixture was demonstrated to modulated cells crucial for gut immune homeostasis by increasing regulatory T and B cells in the gut of probiotic-treated aged mice (Finamore et al, 2019). Also, the administration of probiotic mixture comprising of 8 Gram-positive bacterial strains induced a robust change in the composition of intestinal microbiota with an increase in the abundance of Actinobacteria and Bacterioidete in aged mice.…”

Section: Discussionmentioning

confidence: 99%

Is inflammageing influenced by the microbiota in the aged gut? A systematic review

Shintouo

Mets

Beckwée

et al. 2020

Experimental Gerontology

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Ageing is characterized by a low-grade chronic inflammation marked by elevated circulating levels of inflammatory mediators. This chronic inflammation occurring in the absence of obvious infection has been coined as inflammageing and represents a risk factor for morbidity and mortality in the geriatric population. Also, with ageing, important perturbations in the gut microbiota have been underlined and a growing body of literature has implicated age-related gut dysbiosis as contributing to a global inflammatory state in the elderly. Notwithstanding, very little attention has been given to how gut microbiota impact inflammageing. Here, we investigate the available evidence regarding the association between inflammageing and gut microbiota during ageing. PubMed, Web of Science and Scopus were systematically screened, and seven relevant articles in animals or humans were retrieved. The animal studies reported that Parabacteroides, Mucispirillum, Clostridium and Sarcina positively associate with the pro-inflammatory MCP-1 while Akkermansia, Oscillospira, Blautia and Lactobacillus negatively correlate with MCP-1. Furthermore, "aged"-type microbiota were associated with increased levels of IL6, IL-10, Th1, Th2, Treg, TNF-α, TGF-β, p16, SAMHD1, Eotaxin, and RANTES; activation of TLR2, NF-κB and mTOR; and with decreased levels of cyclin E and CDK2. On the other hand, the study on humans demonstrated that bacteria of the phylum Proteobacteria exhibited a positive correlation with IL-6 and IL-8, while Ruminococcus lactaris et rel. portrayed a negative correlation with IL-8. We conclude that changes in "aged"-type gut microbiota are associated with inflammageing.

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“…Modulating the composition of the gut microbiome using probiotics can also rescue the function of several immune cells as well as improve the inflammatory state of the gut. For example, a mixture of Bifidobacterium longum and Lactobacillus helveticus boosts levels of regulatory T and B-cells in aged individuals [ 120 ]. Furthermore, Bacillus coagulans can increase production of anti-inflammatory cytokines in aged humans, thus resulting in an increase in Faecalibacterium prausnitzii populations [ 121 ].…”

Section: Interventionsmentioning

confidence: 99%

Young at Gut—Turning Back the Clock with the Gut Microbiome

et al. 2021

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Over the past century, we have witnessed an increase in life-expectancy due to public health measures; however, we have also seen an increase in susceptibility to chronic disease and frailty. Microbiome dysfunction may be linked to many of the conditions that increase in prevalence with age, including type 2 diabetes, cardiovascular disease, Alzheimer’s disease, and cancer, suggesting the need for further research on these connections. Moreover, because both non-modifiable (e.g., age, sex, genetics) and environmental (e.g., diet, infection) factors can influence the microbiome, there are vast opportunities for the use of interventions related to the microbiome to promote lifespan and healthspan in aging populations. To understand the mechanisms mediating many of the interventions discussed in this review, we also provide an overview of the gut microbiome’s relationships with the immune system, aging, and the brain. Importantly, we explore how inflammageing (low-grade chronic inflammation that often develops with age), systemic inflammation, and senescent cells may arise from and relate to the gut microbiome. Furthermore, we explore in detail the complex gut–brain axis and the evidence surrounding how gut dysbiosis may be implicated in several age-associated neurodegenerative diseases. We also examine current research on potential interventions for healthspan and lifespan as they relate to the changes taking place in the microbiome during aging; and we begin to explore how the reduction in senescent cells and senescence-associated secretory phenotype (SASP) interplay with the microbiome during the aging process and highlight avenues for further research in this area.

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Supplementation with Bifidobacterium longum Bar33 and Lactobacillus helveticus Bar13 mixture improves immunity in elderly humans (over 75 years) and aged mice

Cited by 46 publications

References 65 publications

Ketogenic Diet and Microbiota: Friends or Enemies?

Ketogenic Diet and Microbiota: Friends or Enemies?

Is inflammageing influenced by the microbiota in the aged gut? A systematic review

Young at Gut—Turning Back the Clock with the Gut Microbiome

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