2012
DOI: 10.1590/s0004-28032012000400010
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Abstract: -Context -Diabetes mellitus is a disease characterized by hyperglycemia that, when allowed to progress long-term untreated, develops vascular and neurological complications, which are responsible for the development of alterations in the enteric nervous system in diabetic patients. In the gastrointestinal tract, diabetes mellitus promotes motor and sensory changes, and in the reflex function of this system, causing gastroparesis, diarrhea, constipation, megacolon, slow gastrointestinal transit, gastric stasis … Show more

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Cited by 10 publications
(59 citation statements)
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References 43 publications
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“…[ 48 ] reported that the myenteric plexus regulates mucosal cell proliferation in an inhibitory manner. Loss of myenteric neurons [ 49 ] and enhanced cell body area [ 50 ] of submucous neurons are reported in the literature, and can be associated with reduction of the total number of neurons in diabetes. Tronchini et al .…”
Section: Discussionmentioning
confidence: 99%
“…Supplementation with these vitamins alone also showed promising results with regard to enteral neuroprotection (Pereira et al 2006;Zanoni et al 2007;Pereira et al 2008;Roldi et al 2009;Zanoni et al 2009). However, other studies that tested the effects of these vitamins alone found that vitamin C ) and vitamin E (Tronchini et al 2012) did not preserve enteric neurons in diabetic rats. These results demonstrate that the combination of these antioxidants may more markedly reduce oxidative stress and thus reduce the deleterious effects of diabetes.…”
Section: Discussionmentioning
confidence: 94%