1966
DOI: 10.1038/212617b0
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Supplementary Data on Crotocin—an Antifungal Antibiotic

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Cited by 24 publications
(3 citation statements)
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“…Little is known about the mechanism of action and the effects of type C trichothecenes such as crotocin on the cell and/or organs, only three papers on the topic are referenced in PubMed (Glaz et al, 1966, Liao et al, 1976, Chi and Mirocha, 1978. Like other trichothecenes, crotocin inhibits protein synthesis through ribotoxic action in HeLa cells, but no information is available regarding the possible involvement of oxidative stress in the effect of this toxin on cells.…”
Section: Toxicological Effects Of Type C Trichothecenesmentioning
confidence: 99%
“…Little is known about the mechanism of action and the effects of type C trichothecenes such as crotocin on the cell and/or organs, only three papers on the topic are referenced in PubMed (Glaz et al, 1966, Liao et al, 1976, Chi and Mirocha, 1978. Like other trichothecenes, crotocin inhibits protein synthesis through ribotoxic action in HeLa cells, but no information is available regarding the possible involvement of oxidative stress in the effect of this toxin on cells.…”
Section: Toxicological Effects Of Type C Trichothecenesmentioning
confidence: 99%
“…The trichothecen-&one -+ 7,13-cyclotrichothecenone rearrangement. The 12,13-epoxide of trichothecolone ( 89) is attacked by the 7-carbanion that can be generated in boiling 1 M sodium hydroxide, giving isotrichothecolone (90). Since the nature of this reaction was e l ~c i d a t e d , ' ~~ no further examples have been described.…”
Section: 421mentioning
confidence: 99%
“…These compounds are generally highly toxic to animals and plants and have been identified as significant toxic agents in numerous medically and economically important mycotoxicoses afflicting man and domestic animals (2)(3)(4)(5)(6)(7)(8)(9)(10). Aside from their toxicity to eukaryotes, the 12,13-epoxytrichothecenes are of interest because several possess antineoplastic activity (11,12).…”
mentioning
confidence: 99%