Supplementary Chromium(III) Propionate Complex Does Not Protect Against Insulin Resistance in High-Fat-Fed Rats

Król, Ewelina; Krejpcio, Zbigniew; Iwanik, Katarzyna

doi:10.1007/s12011-013-9877-3

Cited by 17 publications

(19 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The data obtained by Herring et al [ 32 ] strongly suggest that long-term (15-month) Cr3 supplementation does not significantly affect metabolic responses in blood glucose concentration to glucose and insulin in male Wistar rats consuming a normal diet or high-fat, high-carbohydrate cafeteria-style diet. Also Król et al [ 33 ] confirmed that supplementary Cr3, given in the dosages 0.6 and 3 mg· kg −1 b.m. for 8 weeks, did not affect serum glucose, insulin and HOMA-IR index and serum lipid indices, except TAG (tended to decrease) in rats fed high-fat diet.…”

Section: Discussionmentioning

confidence: 91%

“…Similarly, Clodfelder et al [ 4 ] did not observe adverse effects of Cr3 on the Fe status when given to healthy rats or to the animals with type 2 diabetes for 24 weeks as an aqueous solution at doses of 250–1000 μg of Cr· kg −1 b.m. In contrast, Cr3 supplementary in doses 10 and 50 mg· kg −1 diet for 8 weeks increased kidney Fe and spleen Cu contents but did not affect Zn status in rats fed with high-fat diet [ 33 ]. The studies by Shara et al [ 38 , 39 ] demonstrated that long-term supplementation with complex Cr(III) with niacin did not affect the metabolism of Fe in the rat (as assessed by the content of Fe in the serum, TIBC, RBC, haemoglobin and selected indicators of blood morphology).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Effects of Supplementary Cr3 (Chromium(III) Propionate Complex) on the Mineral Status in Healthy Female Rats

Staniek

Krejpcio

2017

Biol Trace Elem Res

Self Cite

View full text Add to dashboard Cite

More and more people use food supplements for various reasons, e.g. to prevent mineral deficiency and diseases (e.g. osteoporosis, diabetes, anaemia). Supplements containing Cr(III) are purchased primarily for weight loss and antidiabetic effects. The aim of this study was to evaluate the effects of supplementary Cr3 {chromium(III) propionate complex, [Cr3O(O2CCH2CH3)6(H2O)3]NO3)} on the mineral status in female Wistar rats. The study was carried out on 30 female Wistar rats, divided into five groups (six animals in each): a control group and test groups fed Cr3 supplemented diets with 100, 200, 500 and 1000 mg Cr · kg−1 diet (equivalent to 10, 20, 50 and 100 mg Cr ·kg−1 body mass (b.m.) per day) given as Cr3 for 4 weeks. Supplementary Cr3 increased the Cr content in tissues in a dose-dependent manner. High dietary doses of Cr3, 20 and 100 mg Cr · kg−1 b.m., increased the Cu content in the liver and spleen as well as the Zn content in the kidneys but decreased the liver Ca content. Doses of 50–100 mg Cr ·kg−1 b.m. decreased the serum Fe concentration and the Fe content in the liver and kidneys. Supplementation with Cr3 at doses of 10 and 100 mg Cr ·kg−1 b.m. did not affect the Mg content in the rats’ tissues. In conclusion, high dietary doses of Cr3 (10 and 100 mg Cr· kg−1 b.m.) given for 4 weeks affected the mineral status of Fe, Zn, Cu and Ca in the tissues of healthy female Wistar rats.

show abstract

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

The Effects of Supplementary Cr3 (Chromium(III) Propionate Complex) on the Mineral Status in Healthy Female Rats

Staniek

Krejpcio

2017

Biol Trace Elem Res

Self Cite

View full text Add to dashboard Cite

show abstract

“…On the other hand, the results obtained by Herring et al [ 54 ] suggest that long-term (15 months) Cr3 supplementation does not significantly impact metabolic responses in blood glucose concentration to glucose and insulin in male rats’ intake of a high-fat diet, high-carbohydrate cafeteria-style diet or normal diet. By contrast, Cr3 supplementation at doses of 10 and 50 mg kg −1 diet for 8 weeks increased the kidney Fe content in rats fed a high-fat diet [ 55 ].…”

Section: Discussionmentioning

confidence: 99%

The Combined Effects of Iron Excess in the Diet and Chromium(III) Supplementation on the Iron and Chromium Status in Female Rats

Staniek

Wójciak

2017

Biol Trace Elem Res

View full text Add to dashboard Cite

Inadequate iron supply has significant consequences to health. There are some relations between the metabolism of different trace elements, such as iron, zinc, copper and chromium. However, the direction of these interactions can be antagonistic or synergistic, and it depends on many factors. The aim of the study was to evaluate the combined effects of supplementary of chromium(III) propionate complex (Cr3) with iron excess on the Cr and Fe status in healthy female rats. The 36 healthy female Wistar rats were divided into six experimental groups (six animals in each) with different Fe levels—adequate (45 mg kg−1—100% RDA) and high (excessive—180 mg kg−1—400% RDA). At the same time, they were supplemented with Cr(III) at doses of 1, 50 and 500 mg kg−1 of diet: C1—control (Fe 45 mg kg−1, Cr 1 mg kg−1); C50 (Fe 45 mg kg−1, Cr 50 mg kg−1); C500 (Fe 45 mg kg−1, Cr 500 mg kg−1); H1 (Fe 180 mg kg−1, Cr 1 mg kg−1); H50 (Fe 180 mg kg−1, Cr 50 mg kg−1); H500 (Fe 180 mg kg−1, Cr 500 mg kg−1). The serum iron level and total iron binding capacity (TIBC) were measured with colorimetric methods. The serum ferritin level was measured by means of electrochemiluminescence immunoassay. The serum transferrin level was measured with the ELISA method. Haematological measurements were made with an automated blood analyser. The Cr and Fe tissular levels were measured with the AAS method. The exposure to a high level of Fe(III) alone or in combination with Cr caused Fe accumulation in tissues, especially in the liver and kidneys, but there were no significant changes in the TIBC, transferrin, ferritin concentration in the serum and most haematological parameters. Moreover, the serum, hepatic and renal Cr concentrations decreased. The doses of supplementary Cr(III) given separately or in combination with high level of Fe(III) disturbed the Cr content in the liver and kidneys of healthy female rats. However, they did not change most of the parameters of Fe metabolism, except the Fe kidney concentration. Supplementary Cr3 decreased the renal Fe level in groups with adequate Fe content in the diet. However, the renal Fe levels increased along with a higher Cr level in the diet in groups with high Fe content. The findings proved a relationship between Fe(III) and Cr(III) metabolism in healthy female rats. However, the direction of change varied and depended on relative amounts of these elements in the diet.

show abstract

“…Administering CGA alone without CrIII fully restored body weight and glucose tolerance, but not insulin tolerance or fed glucose levels, which remained significantly different from RD-fed mice treated with water alone. While few studies failed to detect an insulin-sensitizing role for chromium in humans [ 34 ] and rats fed a high-fat diet for 8 weeks [ 35 ], several others highlighted its metabolic benefits. For instance, it has been shown to reduce hyperglycemia and attenuate insulin resistance in part, by inhibiting the ubiquitin-proteasome pathways mediating degradation of insulin receptor substrate 1 and 2, critical mediators of insulin signaling [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Chlorogenic acid/chromium supplement rescues diet-induced insulin resistance and obesity in mice

et al. 2015

View full text Add to dashboard Cite

Abdominal obesity is a major risk factor for insulin resistance, type 2 diabetes and cardiovascular diseases. Dietary fat induces insulin resistance in humans and rodents. The current study investigates whether a Chlorogenic acid/Chromium III supplement rescues obesity and insulin resistance caused by high-fat feeding of male C57BL/6 J mice for 7 weeks. Administering an oral daily dose of this supplement in the last 3 weeks of feeding reversed diet-induced body weight gain and insulin resistance, assessed by hyperglycemia, glucose intolerance and insulin intolerance. Indirect calorimetry analysis revealed that this effect is mediated at least partly, by increasing energy expenditure and spontaneous locomoter activity. These findings underscore the important role that chlorogenic acid and chromium play in maintaining glucose metabolism and insulin response in mice fed a high-fat diet.

show abstract

Supplementary Chromium(III) Propionate Complex Does Not Protect Against Insulin Resistance in High-Fat-Fed Rats

Cited by 17 publications

References 46 publications

The Effects of Supplementary Cr3 (Chromium(III) Propionate Complex) on the Mineral Status in Healthy Female Rats

The Effects of Supplementary Cr3 (Chromium(III) Propionate Complex) on the Mineral Status in Healthy Female Rats

The Combined Effects of Iron Excess in the Diet and Chromium(III) Supplementation on the Iron and Chromium Status in Female Rats

Chlorogenic acid/chromium supplement rescues diet-induced insulin resistance and obesity in mice

Contact Info

Product

Resources

About