Chlorogenic acid/chromium supplement rescues diet-induced insulin resistance and obesity in mice

Ghadieh, Hilda E.; Smiley, Zachary N.; Kopfman, Melissa W; Najjar, Mona G; Hake, Michael J; Najjar, Sonia M.

doi:10.1186/s12986-015-0014-5

Cited by 36 publications

(15 citation statements)

References 44 publications

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“…CGA also exhibits anti‐inflammatory, antitumor, and immunomodulatory properties (Liang & Kitts, ; Xu, Hu, & Liu, ). Moreover, it has been determined that CGA can improve insulin resistance and prevent diet‐induced obesity (Ghadieh et al., ; Ma, Gao, & Liu, ). Studies have shown that a high‐fat diet supplemented with CGA at 0.02% (m/m) improves body weight, lipid metabolism, and obesity‐related hormones levels in mice fed with a high fat (Cho et al., ).…”

Section: Introductionmentioning

confidence: 99%

Chlorogenic Acid Stimulates the Thermogenesis of Brown Adipocytes by Promoting the Uptake of Glucose and the Function of Mitochondria

Han

Zhang

Guo

et al. 2019

Journal of Food Science

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Brown adipose tissue (BAT) prevents obesity and related diseases by uncoupling oxidative phosphorylation with adenosine triphosphate. Previous studies have demonstrated that polyphenols can promote the thermogenesis of BAT in mice. Chlorogenic acid (CGA) is a common phenolic acid found in fruits and vegetables, as well as traditional Chinese medicine, which is responsible for a variety of physiological activities. However, it is still unclear whether CGA has positive effects on the thermogenesis of BAT. In this study, CGA enhances the thermogenesis and proton leak of brown adipocytes, however, no changes are evident regarding the differentiation of C 3 H 10 T 1/2 into brown adipocytes. Surprisingly, CGA promotes the uptake of glucose by upregulating the glucose transporter 2 and phosphofructokinase. Moreover, CGA increases the number and the function of mitochondrial. Taken together, CGA stimulates thermogenesis of brown adipocytes by promoting the uptake of glucose and the function of mitochondria.

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Section: Introductionmentioning

confidence: 99%

Chlorogenic Acid Stimulates the Thermogenesis of Brown Adipocytes by Promoting the Uptake of Glucose and the Function of Mitochondria

Han

Zhang

Guo

et al. 2019

Journal of Food Science

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“…Epidemiological studies demonstrated that chlorogenic acid (CGA), a type of dietary polyphenol present in high quantities in plants and constituting the main active ingredient in many fruits, vegetables, and plants [16, 17], possesses numerous pharmacological activities, including those associated with antioxidative [18], anticancer [19–21], hypolipidemic [22], antihypertensive [23], anti-inflammatory [24], and hypoglycemic effects. Moreover, studies reported effects related to anti-insulin resistance and obesity [25], and protection against plant pathogenic fungi [26], as well as antimicrobial effects [27], inhibition of bile-duct ligation-induced liver injury [28], and attenuation of lipopolysaccharide-induced acute kidney injury [29]. Furthermore, CGA reportedly exhibits neuroprotective activity [30], and hypoxia-induced angiogenesis [31], and extends the lifespan of Caenorhabditis elegans [32].…”

Section: Introductionmentioning

confidence: 99%

Chlorogenic Acid Functions as a Novel Agonist of PPARγ2 during the Differentiation of Mouse 3T3-L1 Preadipocytes

Peng

Pang

Zhu

et al. 2018

BioMed Research International

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Rosiglitazone (RG) is a well-known activator of peroxisome proliferator-activated receptor-gamma (PPARγ) and used to treat hyperglycemia and type 2 diabetes; however, its clinical application has been confounded by adverse side effects. Here, we assessed the roles of chlorogenic acid (CGA), a phenolic secondary metabolite found in many fruits and vegetables, on the differentiation and lipolysis of mouse 3T3-L1 preadipocytes. The results showed that CGA promoted differentiation in vitro according to oil red O staining and quantitative polymerase chain reaction assays. As a potential molecular mechanism, CGA downregulated mRNA levels of the adipocyte differentiation-inhibitor gene Pref1 and upregulated those of major adipogenic transcriptional factors (Cebpb and Srebp1). Additionally, CGA upregulated the expression of the differentiation-related transcriptional factor PPARγ2 at both the mRNA and protein levels. However, following CGA intervention, the accumulation of intracellular triacylglycerides following preadipocyte differentiation was significantly lower than that in the RG group. Consistent with this, our data indicated that CGA treatment significantly upregulated the expression of lipogenic pathway-related genes Plin and Srebp1 during the differentiation stage, although the influence of CGA was weaker than that of RG. Notably, CGA upregulated the expression of the lipolysis-related gene Hsl, whereas it did not increase the expression of the lipid synthesis-related gene Dgat1. These results demonstrated that CGA might function as a potential PPARγ agonist similar to RG; however, the impact of CGA on lipolysis in 3T3-L1 preadipocytes differed from that of RG.

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“…In human trials, an increase in energy expenditure has been reported, varying from 6% (after 50 mg caffeine intake) [58] to 7% (after 200 mg caffeine consumption) [57]. Chlorogenic acid has been reported to have beneficial effects against obesity and other dysmetabolic disorders, as well as playing a favorable role in energetic metabolism in both human and animal studies [59,60]. In a pilot study, the consumption of 1 cup of green coffee (containing 6 mg caffeine per kg of lean body mass, about 215-280 mg) determined an increase of REE by 6.4% at 30 min and 2.2% at 180 min, with a positive correlation between the chlorogenic acid assumed and the REE values at 30 min [61].…”

Section: Green Coffee Available Evidencementioning

confidence: 99%

A Critical Review on the Role of Food and Nutrition in the Energy Balance

Fadda

Fedele

et al. 2020

Nutrients

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The mass media has increasingly frequently suggested to the general population that specific foods or nutritional schemes are able to affect both human metabolism and energy expenditure, thus facilitating weight loss. This critical review is aimed at assessing available evidence on the roles of nutrients, food and dietary regimens in energy intake and energy expenditure. We queried the National Library of Medicine, the Cochrane Library, Excerpta Medica dataBASEand the Cumulative Index to Nursing and Allied Health Literature database, and a search strategy was performed by using database-specific subject headings and keywords. We found that available scientific evidence on these topics is scarce, and that the limited number of available studies often have poor methodological quality. Only a few foods show beneficial effects on metabolism and energy expenditure, as the human energy balance is complex and multifactorial. Finally, microbiota may interfere with the intake, use and expenditure of energy in the human body. Conclusive evidence is still lacking, and, at present, it is not possible to identify a food or a diet with a significant impact on human energy expenditure.

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Chlorogenic acid/chromium supplement rescues diet-induced insulin resistance and obesity in mice

Cited by 36 publications

References 44 publications

Chlorogenic Acid Stimulates the Thermogenesis of Brown Adipocytes by Promoting the Uptake of Glucose and the Function of Mitochondria

Chlorogenic Acid Stimulates the Thermogenesis of Brown Adipocytes by Promoting the Uptake of Glucose and the Function of Mitochondria

Chlorogenic Acid Functions as a Novel Agonist of PPARγ2 during the Differentiation of Mouse 3T3-L1 Preadipocytes

A Critical Review on the Role of Food and Nutrition in the Energy Balance

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