Supplemental vitamin D enhances the recovery in peak isometric force shortly after intense exercise

Barker, Tyler; Schneider, Erik; Dixon, Brian; Henriksen, Vanessa T.; Weaver, Lindell K.

doi:10.1186/1743-7075-10-69

Cited by 70 publications

(92 citation statements)

References 34 publications

(43 reference statements)

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“…Consistent with previous data [40,41,57], there was a significant increase in serum 25(OH)D (from approximately 28.0 to 38.4 (peak at 7-d) ng/mL) following a large bolus of cholecalciferol that inversely correlated with Bsl concentrations. Extending on previous findings, this study provides new results suggesting subjects with high serum 25(OH)D at Bsl possess the greatest change in VDBP concentrations following a 100,000 IU bolus of cholecalciferol.…”

Section: Discussionsupporting

confidence: 90%

“…As demonstrated by our lab [40] and others [41], Bsl serum 25(OH)D inversely correlated (p<0.05) with the change in serum 25(OH)D following supplementation (Table 4). Extending those findings, we found that serum 25(OH)D and VDBP at Bsl positively and negatively correlated, respectively, with the Δ in VDBP at 7-d.…”

Section: Vitamin D Metabolite Correlations In the Vd Groupsupporting

confidence: 66%

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Soluble TNF Receptors are Modulated by Vitamin D Status but not by Acute Perturbations in 25-Hydroxyvitamin D Following A Bolus of Supplemental Vitamin D

Barker¹,

Brown²,

Rogers³

2017

J Cytokine Biol

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The first objective of this study was to identify if soluble tumor necrosis factor-receptor 1 (sTNFr1) and -receptor 2 (sTNFr2) are modulated by vitamin D status (insufficient vs. sufficient). The second objective was to reveal if soluble TNF receptors fluctuate with serum 25-hydroxyvitamin D (25(OH)D) concentrations following a bolus of supplemental vitamin D. Reportedly healthy male adults were randomly (double-blind) assigned to a placebo (n=15) or vitamin D (100,000 IU of cholecalciferol; n=14) supplement. Supplements were taken as a bolus immediately after and on the same day as providing the first blood sample (baseline (Bsl)). Fasting blood samples were also obtained

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Section: Discussionsupporting

confidence: 90%

Section: Vitamin D Metabolite Correlations In the Vd Groupsupporting

confidence: 66%

Soluble TNF Receptors are Modulated by Vitamin D Status but not by Acute Perturbations in 25-Hydroxyvitamin D Following A Bolus of Supplemental Vitamin D

Barker¹,

Brown²,

Rogers³

2017

J Cytokine Biol

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“…28 Furthermore, a RCT of 28 healthy adults found 100 m day of vitamin D 3 enhanced the recovery in peak isometric force after a muscle-damaging event (P < 0.05). 29 In that study, supplemental vitamin D 3 attenuated (P < 0¢05) the immediate and delayed (2 day, 3 day and 7 day) increase in circulating biomarkers of muscle damage.…”

mentioning

confidence: 76%

Vitamin D and inflammation

Cannell¹,

Grant

Holick

2014

Dermato-Endocrinology

169

131

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Abbreviations: CRP, C-reactive protein; CXCL9, CXC chemokine ligand 9; E-selectin, ESR, erythrocyte sedimentation rate, F1C2, prothrombin fragment 1C2; IFG, impaired fasting glucose; IL, interleukin; MCP-1, monocyte chemoattractant protein-1; NGAL, neutrophil gelatinase-associated lipocalin; NGT, normal glucose tolerance; ns, not stated; PAI-1, plasminogen activator inhibitor-1; sICAM-1, soluble intracellular adhesion molecule-1; sTNF-R2, soluble tumor necrosis factor a receptor type 2; TAT, thrombin antithrombin complex; TGF-b, transforming growth factor-b; TNF-a, tumor necrosis factor-a Seventeen found significantly reduced inflammatory markers, 19 did not, one was mixed and one showed adverse results. With few exceptions, studies in normal subjects, obesity, type 2 diabetics, and stable cardiovascular disease did not find significant beneficial effects. However, we found that 6 out of 7 RCTS of vitamin D 3 in highly inflammatory conditions (acute infantile congestive heart failure, multiple sclerosis, inflammatory bowel disease, cystic fibrosis, SLE, active TB and evolving myocardial infarction) found significant reductions. We found baseline and final 25(OH)D predicted RCTs with significant reduction in inflammatory markers. Vitamin D tends to modestly lower markers of inflammation in highly inflammatory conditions, when baseline 25(OH)D levels were low and when achieved 25(OH)D levels were higher. Future inquiries should: recruit subjects with low baseline 25(OH)D levels, subjects with elevated markers of inflammation, subjects with inflammatory conditions, achieve adequate final 25(OH)D levels, and use physiological doses of vitamin D. We attempted to identify all extant randomized controlled trials (RCTs) of vitamin D that used inflammatory markers as primary or secondary endpoints.

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“…Vitamin D stimulates the muscle production of vascular endothelial growth factor and insulin‐like growth factor‐1 (IGF‐1), which are involved in muscle regeneration after injury, as well as in bone growth and density 61, 62, 63. This may explain how the administration of vitamin D improves the recovery of skeletal muscle strength due to intense exercise 64. 1,25(OH) 2 D also brings the expression of osteoglycin, another bone anabolic factor that is produced by muscle tissues 65…”

Section: Vitamin D Physiologymentioning

confidence: 99%

Vitamin D, a modulator of musculoskeletal health in chronic kidney disease

Molina

Carrero

Bover

et al. 2017

J cachexia sarcopenia muscle

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The spectrum of activity of vitamin D goes beyond calcium and bone homeostasis, and growing evidence suggests that vitamin D contributes to maintain musculoskeletal health in healthy subjects as well as in patients with chronic kidney disease (CKD), who display the combination of bone metabolism disorder, muscle wasting, and weakness. Here, we review how vitamin D represents a pathway in which bone and muscle may interact. In vitro studies have confirmed that the vitamin D receptor is present on muscle, describing the mechanisms whereby vitamin D directly affects skeletal muscle. These include genomic and non‐genomic (rapid) effects, regulating cellular differentiation and proliferation. Observational studies have shown that circulating 25‐hydroxyvitamin D levels correlate with the clinical symptoms and muscle morphological changes observed in CKD patients. Vitamin D deficiency has been linked to low bone formation rate and bone mineral density, with an increased risk of skeletal fractures. The impact of low vitamin D status on skeletal muscle may also affect muscle metabolic pathways, including its sensitivity to insulin. Although some interventional studies have shown that vitamin D may improve physical performance and protect against the development of histological and radiological signs of hyperparathyroidism, evidence is still insufficient to draw definitive conclusions.

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Supplemental vitamin D enhances the recovery in peak isometric force shortly after intense exercise

Cited by 70 publications

References 34 publications

Soluble TNF Receptors are Modulated by Vitamin D Status but not by Acute Perturbations in 25-Hydroxyvitamin D Following A Bolus of Supplemental Vitamin D

Soluble TNF Receptors are Modulated by Vitamin D Status but not by Acute Perturbations in 25-Hydroxyvitamin D Following A Bolus of Supplemental Vitamin D

Vitamin D and inflammation

Vitamin D, a modulator of musculoskeletal health in chronic kidney disease

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