Supplemental Sodium Phytate and Microbial Phytase Influence Iron Availability in Growing Rats

Pallauf, J.; Pippig, S.; Most, Erika; Rimbach, Gerald

doi:10.1016/s0946-672x(99)80003-0

Cited by 17 publications

(7 citation statements)

References 30 publications

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“…Further studies are required to fully elucidate the impact of phyate on Mn bioavailability. Fe availability was not affected by phytase supplementation, which was inconsistent with previous reports [30][31][32]. The differences may be caused by the excess dietary Fe content in the current study, which was three times higher than the requirement recommendation of NRC [8].…”

Section: Discussioncontrasting

confidence: 99%

Super High Dosing with a Novel Buttiauxella Phytase Continuously Improves Growth Performance, Nutrient Digestibility, and Mineral Status of Weaned Pigs

Zeng

Tian

et al. 2015

Biol Trace Elem Res

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This study was conducted to evaluate the efficacy of a novel Buttiauxella phytase to pigs fed P-deficient, corn-soybean meal diets. One hundred and twenty crossbred piglets (9.53 ± 0.84 kg) were allocated to one of five treatments which consisted of four low P diets (0.61 % Ca and 0.46 % total P) supplemented with 0, 500, 1,000, or 20,000 FTU/kg phytase as well as a positive control diet (0.77 % Ca and 0.62 % total P). Each treatment had six replicated pens with four pigs per pen. Pigs were fed the experimental diets for 28 days. Phytase supplementation linearly improved (P < 0.05) average daily gain (ADG), feed conversion ratio (FCR), and apparent total tract digestibility (ATTD) of dry matter, gross energy, crude protein, Ca, and P in weaned pigs. Super high dosing with phytase (20,000 FTU/kg) further increased (P < 0.05) ADG compared with 500 FTU/kg phytase inclusion group, as well as ATTD of Ca and P. Metacarpal bone characteristics and several trace mineral concentration in bone, plasma, or organ tissues were linearly (P < 0.05) improved at increasing dose of phytase. Super high dosing with phytase (20,000 FTU/kg) supplementation improved (P < 0.05) Mn and Zn concentration in bone compared to normal dose of phytase supplementation (500 or 1,000 FTU/kg). In conclusion, supplementation of 500 FTU of Buttiauxella phytase/kg and above effectively hydrolyzed phytate in a low-P corn-soybean diet for pigs. In addition, a super high dosing with phytase (20,000 FTU/kg) improved macro- or micro mineral availability and growth performance.

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Section: Discussioncontrasting

confidence: 99%

Super High Dosing with a Novel Buttiauxella Phytase Continuously Improves Growth Performance, Nutrient Digestibility, and Mineral Status of Weaned Pigs

Zeng

Tian

et al. 2015

Biol Trace Elem Res

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“…Formation of Fe-phytate complexes is expected to make Fe less available for digestion and absorption. The linear increase in the ATTD of Fe as phytase was used that was demonstrated in this experiment is in agreement with results of studies with humans and rats (Pallauf et al, 1999;Hurrell et al, 2003). In contrast, the lack of a response to microbial phytase on the ATTD of Mn was surprising because Mn content of bone and kidney has been reported to be increased by inclusion of 20,000 FTU of phytase by Zeng et al, 2015. However, it is possible that a greater concentration of phytase than was used in this experiment is needed to increase the ATTD of Mn in pigs.…”

Section: Apparent Total Tract Digestibility Of Cu Fe and Mnsupporting

confidence: 91%

Effects of increasing concentrations of an Escherichia coli phytase on the apparent ileal digestibility of amino acids and the apparent total tract digestibility of energy and nutrients in corn-soybean meal diets fed to growing pigs1

She

Sparks²,

Stein

2018

Journal of Animal Science

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An experiment was conducted to test the hypothesis that inclusion of increasing concentrations of an Escherichia coli phytase to a corn-soybean meal (SBM) diet results in improved digestibility of DM, GE, CP, NDF, ADF, macrominerals, microminerals, and AA. Twenty-four growing barrows (initial BW: 37.0 ± 1.4 kg) were equipped with a T-cannula in the distal ileum and placed individually in metabolism crates, and allotted to a 2-period switch-back design with 6 diets and 4 replicate pigs per diet in each period. The positive control diet was a corn-SBM diet that contained limestone and dicalcium phosphate to meet the requirement for standardized total tract digestible (STTD) P and Ca (0.31% STTD P and 0.70% Ca). A negative control diet that was similar to the positive control diet, with the exception that no dicalcium phosphate was used, was also formulated, and this diet contained 0.16% STTD P and 0.43% Ca. Four additional diets were formulated by adding 500, 1,000, 2,000, or 4,000 units of microbial phytase (FTU) to the negative control diet. Each period lasted 14 d. Fecal and urine samples were collected from the feed provided from days 6 to 11 of each period following 5 d of adaptation to the diets. Ileal digesta were collected for 8 h on days 13 and 14. Results indicated that addition of the E. coli phytase to the negative control diet tended to quadratically improve the apparent ileal digestibility of Phe (P = 0.086) and Asp (P = 0.054), and linearly increased (P < 0.05) the apparent total tract digestibility (ATTD) of ADF, K, and Fe. Microbial phytase also quadratically increased (P < 0.05) the ATTD of NDF and Mg, and linearly and quadratically increased (P < 0.05) the ATTD and retention of Ca and P. However, no effects of the phytase on ATTD of GE or the concentration of DE were observed. In conclusion, the increased absorption of several minerals including Ca, P, K, Mg, and Fe that was observed as increasing concentrations of an E. coli phytase was added to a corn-SBM meal diet indicates that the dietary provision of these minerals may be reduced if phytase is fed.

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“…6) Ever since up to now, several studies have attributed "anti-nutritional" properties to phytate. [7][8][9][10][11] Nevertheless, other studies [12][13][14][15][16] have shown that those findings are not quite so clear and simple as mentioned. Moreover, from the 1980s to the present, important physiological functions of InsP 6 have been suggested as its properties as an antioxidant 17,18) and its role in colon cancer prevention.…”

mentioning

confidence: 99%

Study of the Absorption of Myo-Inositol Hexakisphosphate (InsP6) through the Skin

Gráses

Perelló

Isern

et al. 2005

Biological & Pharmaceutical Bulletin

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Myo-inositol hexakisphosphate (InsP 6 ) is an abundant component of plant seeds. In whole grain cereals it ranges from 1.5 to 6.4% and it is mostly associated with calcium and magnesium ions, the so-called phytin. 1,2) Recently it was found that InsP 6 is also present in all mammalian organs, tissues and fluids but at significantly low amounts. Moreover, it was demonstrated that the levels found in biological fluids (blood, urine, interstitial liquid) and mammalian tissues clearly depended on the dietary intake. [3][4][5] Diverse studies performed by Mellanby demonstrated that a high InsP 6 content in some diets, as sodium salt, reduced calcium absorption and induced rickets. 6) Ever since up to now, several studies have attributed "anti-nutritional" properties to phytate. [7][8][9][10][11] Nevertheless, other studies [12][13][14][15][16] have shown that those findings are not quite so clear and simple as mentioned. Moreover, from the 1980s to the present, important physiological functions of InsP 6 have been suggested as its properties as an antioxidant 17,18) and its role in colon cancer prevention. 19,20) The InsP 6 present in urine and biological fluids also exhibited an important role in preventing pathological calcifications as renal calculi [21][22][23] or calcinosis cutis, 24) due to its powerful capacity to act as crystallization inhibitor of calcium salts.Finally, the most recent observations about the properties of InsP 6 are related to its dermatological use. The majority of those applications are referred to their important action on premature aging or as discolouring agent of the skin.25) Also some studies seem to demonstrate a capacity of InsP 6 to inhibit skin cancer. 26,27) In the present paper a first study of the absorption of InsP 6 through the skin is developed. MATERIALS AND METHODS Animals, Diets and Experimental DesignTwenty-four female Wistar rats of approximately 225 g from Harlan Iberica s.l. (Barcelona, Spain) were acclimated in the course of 7 d to our animal house. Animals were kept in Plexiglas cages (two animals per cage) at a temperature of 21Ϯ1°C and relative humidity of 60Ϯ5% with a 12-h on-off light cycle. After this period, animals were randomly assigned into four groups of six rats respectivelly. Rats were fed with 4068.02 Reference Diet (HopeFarms BV, Woerden, The Netherlands), a synthetic purified diet (Table 1) in which InsP 6 is undetectable.After a period of 16 d consuming such diet, during which the urinary InsP 6 became undetectable, rats were topically treated once a day with 4 g of a standard cream with a supplement of 0.4, 1.2 and 2.0% of InsP 6 as sodium salt or 2.0% of InsP 6 as calcium magnesium salt (phytin). The surface of treatment was about 50 cm 2 . The application area was located on the back skin of the animal and was previously shaved using an electric shaver (each 4 d). During cream treatment animals were located individually to avoid licking cream. pH of all creams was adjusted to 4-4.5 (see Table 2). Samples of 24-h urine were collected at days 0, 7 ...

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Supplemental Sodium Phytate and Microbial Phytase Influence Iron Availability in Growing Rats

Cited by 17 publications

References 30 publications

Super High Dosing with a Novel Buttiauxella Phytase Continuously Improves Growth Performance, Nutrient Digestibility, and Mineral Status of Weaned Pigs

Super High Dosing with a Novel Buttiauxella Phytase Continuously Improves Growth Performance, Nutrient Digestibility, and Mineral Status of Weaned Pigs

Effects of increasing concentrations of an Escherichia coli phytase on the apparent ileal digestibility of amino acids and the apparent total tract digestibility of energy and nutrients in corn-soybean meal diets fed to growing pigs1

Study of the Absorption of Myo-Inositol Hexakisphosphate (InsP6) through the Skin

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