Supplemental Selenium May Decrease Ovarian Cancer Risk in African-American Women

Terry, Paul; Qin, Bo; Camacho, Fabian; Moorman, Patricia G.; Alberg, Anthony J.; Barnholtz‐Sloan, Jill S.; Bondy, Melissa L.; Coté, Michele L.; Funkhouser, Ellen; Guertin, Kristin A.; Peters, Edward S.; Schwartz, Ann G.; Schildkraut, Joellen M.; Bandera, Elisa V.

doi:10.3945/jn.116.243279

Cited by 16 publications

(17 citation statements)

References 47 publications

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“…Selenium is an essential micronutrient involved in several important intracellular process, and low doses of selenite treatment are inversely correlated with the risk of cancer that acts as a pro-oxidant to induce tumor cell apoptosis (25,26). For some cancer cells, sodium selenite acts an antioxidant that protect cells against oxidative damage (27,28), however, it is also known to increase intracellular ROS levels.…”

Section: Discussionmentioning

confidence: 99%

Oral intake of α‑glucosyl‑hesperidin ameliorates selenite‑induced cataract formation

et al. 2020

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Hesperetin is a natural flavonoid with robust antioxidant properties. Our previous study reported that hesperetin can prevent cataract formation. However, an important consideration regarding hesperetin consumption is the limited bioavailability due to its poor solubility. The present study investigated the anti-cataract effects of α-glucosyl hesperidin in vivo and in vitro using a selenite-induced cataract model. SD rats (age, 13 days) were orally administered PBS (0.2 ml) or α-glucosyl hesperidin (200 mg/kg) on days 0, 1 and 2. Sodium selenite was subcutaneously administered to the rats 4 h after the first oral administration on day 0. Antioxidant levels in the lens and blood were measured on day 6. In vitro, human lens epithelial cells were treated with sodium selenite (10 µM) and/or hesperetin (50 or 100 mM) for 24 h and analyzed for apoptosis markers using sub-G 1 population and Annexin V-FITC/propidium iodide staining and DNA ladder formation. α-glucosyl hesperidin treatment significantly reduced the severity of selenite-induced cataract. The level of antioxidants was significantly reduced in the selenite-treated rats compared with in the controls; however, they were normalized with α-glucosyl hesperidin treatment. In vitro, hesperetin could significantly reduce the number of cells undergoing apoptosis induced by sodium selenite in human lens epithelial cell lines. Overall, oral consumption of α-glucosyl hesperidin could delay the onset of selenite-induced cataract, at least in part by modulating the selenite-induced cell death in lens epithelial cells.

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Section: Discussionmentioning

confidence: 99%

Oral intake of α‑glucosyl‑hesperidin ameliorates selenite‑induced cataract formation

et al. 2020

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“…High dietary intake of B carotene is reported to be protective against epithelial ovarian cancer; in a meta-analysis of over 3782 subjects, a modest 16% reduced risk was found [133]. Supplemental selenium (>20 μg daily) is associated with 30% risk reduction [134]. This fact, however, does not support use of selenium as a preventive strategy [135].…”

Section: Diet and Ovarian Cancermentioning

confidence: 96%

Risk Factors for Ovarian Cancer

Zayyan¹

2020

Tumor Progression and Metastasis

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Ovarian cancers remain a perplexing group of diseases that continue to raise questions over their etiology and clinical behavior. They are the most fatal of gynecological cancers. Despite a global lifetime risk of only 1-2%, they contribute the highest mortality and the lowest 5-year (overall) survival rate of just 35%. The three broad histological groups: epithelial, sex cord-stromal and germ cell cancers have different biologic behavior and may constitute different clinical disease entities. Of the eight subtypes in the epithelial group, high-grade serous are universally the most common and have the worst prognosis. Globally making 65-85% of all ovarian cancers, most of the focus on risk factors has been directed on the epithelial group but the importance of other primary malignancies cannot be overemphasized as a step towards understanding their etiology and clinical behavior. The normal ovary has none of the epithelia that produce the range of epithelial ovarian cancers or there is an obvious premalignant stage, symptoms are very vague, screening and early diagnosis are difficult and indeed unrewarding. No specific etiology is known for any of the histologic groups. However, commonly mentioned risk factors like increasing age, genetics, nulliparity, prolonged infertility, use of fertility drugs, high animal fat, obesity, endometriosis, polycystic ovary syndrome, previous history of cancer, use of hormone replacement therapy, pelvic inflammatory disease and smoking may not apply to all the subtypes, while factors like increasing parity, breast feeding, use of oral contraceptive pills, hysterectomy, tubal ligation and use of antioxidants may differ in the degree of protection they provide. There may also be geographical and probably racial variations in the relevance of some of the risk factors. Thorough understanding of the predisposing and protective factors of the various histologic subtypes is an important step understanding the disease and therefore improving treatment outcome or providing effective prevention.

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“…The study found a positive association between lifetime ovulatory cycles and epithelial OC in AA women, similar to what was already known in CA patients. The association of antioxidant selenium uptake and risk of OC in AA women was also studied in a cohort of 406 AA OC patients and 632 AA healthy (control) women that were age- and site-matched [ 14 ]. Consistent with the beneficial effects of antioxidants, women with high selenium intakes were found to be at ~30% lowered risk of OC.…”

Section: Disparity In Ovarian Cancer Incidence and Mortalitymentioning

confidence: 99%

Racial health disparities in ovarian cancer: not just black and white

et al. 2017

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Ovarian cancer (OC) is the most lethal gynecological malignancy, which disproportionately affects African American (AA) women. Lack of awareness and socioeconomic factors are considered important players in OC racial health disparity, while at the same time, some recent studies have brought focus on the genetic basis of disparity as well. Differential polymorphisms, mutations and expressions of genes have been reported in OC patients of diverse racial and ethnic backgrounds. Combined, it appears that neither genetic nor the socioeconomic factors alone might explain the observed racially disparate health outcomes among OC patients. Rather, a more logical explanation would be the one that takes into consideration the combination and/or the interplay of these factors, perhaps even including some environmental ones. Hence, in this article, we attempt to review the available information on OC racial health disparity, and provide an overview of socioeconomic, environmental and genetic factors, as well as the epigenetic changes that can act as a liaison between the three. A better understanding of these underlying causes will help further research on effective cancer management among diverse patient population and ultimately narrow health disparity gaps.

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Supplemental Selenium May Decrease Ovarian Cancer Risk in African-American Women

Abstract: Background: To our knowledge, no previous study has evaluated the associations of antioxidant intake with the risk of

Cited by 16 publications

References 47 publications

Oral intake of α‑glucosyl‑hesperidin ameliorates selenite‑induced cataract formation

Oral intake of α‑glucosyl‑hesperidin ameliorates selenite‑induced cataract formation

Risk Factors for Ovarian Cancer

Racial health disparities in ovarian cancer: not just black and white

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