Supplemental Phytic Acid and Microbial Phytase Change Zinc Bioavailability and Cadmium Accumulation in Growing Rats

Rimbach, Gerald; Brandt, Karsten; Most, Erika; Pallauf, J.

doi:10.1016/s0946-672x(11)80020-9

Cited by 30 publications

(15 citation statements)

References 21 publications

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“…Further long-term studies with rats [29] confirmed the beneficial function of sufficient dietary zinc intake in counteracting cadmium intoxication. In a previous experiment [16] studying the effect of PA and microbial phytase on zinc bioavailability and cadmium ac cumulation by feeding diets supplemented with only 15 mg Zn but also 5 mg Cd per kilo gram it could be shown that the addition of 0.5% sodium phytate (molar PA/Zn ratio -33) reduced zinc status and enhanced cad mium accumulation. These negative effects of PA could be considerably counteracted by the supplementation of microbial phytase.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the purpose of the present study was to determine whether dietary phytate and the addition of microbial phytase to a sodium phytate enriched diet influence cadmium accumulation, zinc status, and apparent absorption of zinc, calcium, phosphorus, magnesium, iron, copper, and manganese in growing rats. In a previous exper iment [ 16] with growing rats feeding diets con taining only 15 mgzincbut also 5 mg cadmium per kilogram diet, it could be shown that phytic acid (PA) reduced zinc status and enhanced cadmium accumulation. In order to avoid a reduced zinc bioavailabilitv due to dietary' phy tate accompanied by a strong zinc cadmium interaction, diets highly enriched with zinc (100 mg Zn/kg diet) were fed in the present trial.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Phytic Acid and Microbial Phytase on Cd Accumulation, Zn Status, and Apparent Absorption of Ca, P, Mg, Fe, Zn, Cu, and Mn in Growing Rats

et al. 1995

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Three groups of individually housed albino rats (n = 6, initial average weight = 47 g) were fed diets based on egg white and cornstarch (basal diet 8 g Ca, 5.2 g P, 0.76 g Mg, 100 mg Zn, 100 mg Fe, 50 mg Mn, 7 mg Cu, and 5 mg Cd per kilogram diet) over a 4-week period. Group I (controls) was fed the basal diet free of phytic acid (PA) and microbial phytase. In groups II and III cornstarch was replaced by 0.5% PA from NaPA (molar PA/Zn ratio ∼ 5). In group III, 2,000 U of microbial phytase from Aspergillus niger per kilogram diet was added. Live weight gain, zinc status (zinc in plasma, femur, liver, and testes; activity of the plasma alkaline phosphatase), and apparent absorption of zinc, iron, copper, and manganese remained unchanged by the different dietary treatments. The apparent phosphorus absorption was highest in the phytase group. PA decreased and microbial phytase improved thv apparent absorption of calcium and magnesium. Liver cadmium concentration, total liver and kidney cadmium content, as well as fractional liver and kidney cadmium accumulation in rats fed the diet containing PA were significantly higher than those in the controls. Phytase supplementation lowered liver and kidney cadmium accumulation. Differences in calcium and magnesium bioavailability due to PA and microbial phytase may be one factor in the alteration of tissue cadmium accumulation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Phytic Acid and Microbial Phytase on Cd Accumulation, Zn Status, and Apparent Absorption of Ca, P, Mg, Fe, Zn, Cu, and Mn in Growing Rats

et al. 1995

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“…Applying a fish-meal diet in rats either with or without sodium phytate, Yannai and Sachs found no effect on the cadmium, lead and mercury absorption in this diet after addition of sodium phytate [250]. In a study with albino rats, Rimbach et al [251] fed three diets based on egg white and corn starch and supplemented by zinc (15 mg/kg) and cadmium (5 mg/ kg). The control diet (diet 1) was free of phytate and active phytases while the both experimental diets contained either 0.5% sodium phytate (diet 2) or 0.5% sodium phytate plus microbial phytases (2000 U/kg) (diet 3).…”

Section: Phytic Acid Interactions With Toxic Trace Elements (Cd Pb)mentioning

confidence: 99%

Phytate in foods and significance for humans: Food sources, intake, processing, bioavailability, protective role and analysis

Schlemmer¹,

Frølich

Prieto

et al. 2009

Molecular Nutrition Food Res

708

604

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The article gives an overview of phytic acid in food and of its significance for human nutrition. It summarises phytate sources in foods and discusses problems of phytic acid/phytate contents of food tables. Data on phytic acid intake are evaluated and daily phytic acid intake depending on food habits is assessed. Degradation of phytate during gastro-intestinal passage is summarised, the mechanism of phytate interacting with minerals and trace elements in the gastro-intestinal chyme described and the pathway of inositol phosphate hydrolysis in the gut presented. The present knowledge of phytate absorption is summarised and discussed. Effects of phytate on mineral and trace element bioavailability are reported and phytate degradation during processing and storage is described. Beneficial activities of dietary phytate such as its effects on calcification and kidney stone formation and on lowering blood glucose and lipids are reported. The antioxidative property of phytic acid and its potentional anticancerogenic activities are briefly surveyed. Development of the analysis of phytic acid and other inositol phosphates is described, problems of inositol phosphate determination and detection discussed and the need for standardisation of phytic acid analysis in foods argued.

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“…The addition of supplemental phytase to the diet is effective in improving PA digestibility, as recent studies have demonstrated the ability of dietary phytase to improve micronutrient status, body weight and bone strength in animals [15 -18]. Zinc status and growth are affected by dietary phytase, as addition of microbial phytases to PA-rich soybased diets has been shown to enhance Zn utilization and increase body weight gain in growing rats [19,20].…”

Section: Introductionmentioning

confidence: 99%

Effects of dietary phytase on body weight gain, body composition and bone strength in growing rats fed a low-zinc diet

McClung

Stahl

Marchitelli

et al. 2006

The Journal of Nutritional Biochemistry

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Supplemental Phytic Acid and Microbial Phytase Change Zinc Bioavailability and Cadmium Accumulation in Growing Rats

Cited by 30 publications

References 21 publications

Effect of Phytic Acid and Microbial Phytase on Cd Accumulation, Zn Status, and Apparent Absorption of Ca, P, Mg, Fe, Zn, Cu, and Mn in Growing Rats

Effect of Phytic Acid and Microbial Phytase on Cd Accumulation, Zn Status, and Apparent Absorption of Ca, P, Mg, Fe, Zn, Cu, and Mn in Growing Rats

Phytate in foods and significance for humans: Food sources, intake, processing, bioavailability, protective role and analysis

Effects of dietary phytase on body weight gain, body composition and bone strength in growing rats fed a low-zinc diet

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