Effects of dietary phytase on body weight gain, body composition and bone strength in growing rats fed a low-zinc diet

McClung, James P.; Stahl, Chad H.; Marchitelli, Louis J.; Morales-Martinez, Nelson; Mackin, Katherine M.; Young, Andrew; Scrimgeour, Angus G.

doi:10.1016/j.jnutbio.2005.07.003

Cited by 23 publications

(18 citation statements)

References 47 publications

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“…With regard to the zinc and silver, studies 19 have shown that zinc plays an important role in skeletal growth and development as well as maintenance of bone health. It is a cofactor of alkaline phosphatase, which is responsible for formation and mineralization of the bone matrix.…”

Section: Discussionmentioning

confidence: 99%

Cytotoxicity of Silver Solder Employed in Orthodontics

Freitas

Oshima

Menezes

et al. 2009

The Angle Orthodontist

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Objective: To test the null hypothesis that the silver soldering employed in orthodontics is not cytotoxic for fibroblasts. Materials and Methods: This in vitro study was performed using a culture of mice fibroblasts (lineage NIH/3T3), divided into four groups (n ϭ 10 each): control, negative control (stainless steel archwire), positive control (amalgam disks), and test group (silver soldering). After cell culture in complete Dulbecco modified eagle medium and achievement of confluence in 80%, the suspension was added to the plates of 24 wells containing the specimens and incubated in an oven at 37ЊC for 24 hours. The plates were analyzed on an inverted light microscope, photomicrographs were obtained, and the results were recorded as response rates based on modifications of the parameters of Stanford according to the size of the diffusion halo of the toxic substance and quantity of cell lysis. Results:The results revealed a maximum response rate for the silver soldering group, as well as severe inhibition of cell proliferation and growth, more round cells with mostly darkened and granular aspects, suggesting lysis with cell death. A similar response was seen in the positive control group. Conclusion: The hypothesis is rejected. The silver soldering used in orthodontics represents a highly cytotoxic material for the cells analyzed. (Angle Orthod. 2009;79:939-944.)

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Section: Discussionmentioning

confidence: 99%

Cytotoxicity of Silver Solder Employed in Orthodontics

Freitas

Oshima

Menezes

et al. 2009

The Angle Orthodontist

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“…In general, OB bean cooked with and without soaking water promoted better retention of minerals in the bones of the animals (Table 5). In an- other study Yonekura and Suzuki (2005) observed a strong correlation between zinc apparent absorption and the concentration of zinc in the femur and according to results of McClung et al (2006) improving the bioavailability of Zn could have profound effects on bone integrity. It was verified that only BRS bean cooked without soaking water differed from the standard diet (P < 0.05), in relation to the femur weight.…”

Section: Biological Testmentioning

confidence: 90%

“…Alkaline phosphatase is an enzyme produced mainly by osteoblasts, whose main function is to promote the deposition of calcium in bone diaphysis (Dimai, Hall, Stilt-Coffing, & Farley, 1998). The activity of alkaline phosphatase decreases quickly in animals submitted to zinc-deficient diets (Chesters, 1997;McClung et al, 2006), and depends on magnesium (Chen et al, 2000). As a consequence, low contents of zinc and magnesium would imply lower retention of calcium.…”

Section: Biological Testmentioning

confidence: 99%

Zinc bioavailability in different beans as affected by cultivar type and cooking conditions

Ramírez-Cárdenas

Leonel

Costa

et al. 2010

Food Research International

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a b s t r a c tZinc bioavailability was studied in five cultivars of beans (Phaseolus vulgaris, L): white (Ouro Branco), black (Diamante Negro), and brown (BRS Radiante, Pérola and Talismã) cooked with or without soaking water. The cooked bean flours or ZnCO 3 were added to the test or control diets to provide 15 mg Zn/kg diet and were fed to weaning Wistar male rats for 42 days. Blood and femur were collected for analyses of plasma and erythrocyte Zn, bone weight and bone/dietary mineral ratio. Zinc bioavailability of Ouro Branco bean cooked with soaking water was higher than the other cultivars and similar to the control diet. Talismã without soaking water showed the lowest values for most of the parameters analyzed. Zinc bioavailability was not affected neither by the cooking process itself nor by the contents of phytate, tannins and dietary fiber, but it varied according to the bean cultivar and the phytate Â calcium:zinc molar ratio.

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“…Isocaloric diets were formulated to contain either marginal (5 mg/kg) or supplemental (300 mg/kg) levels of Zn by adjusting the concentration of Zn carbonate added to the mineral mix. The final Zn concentrations of the diets were confirmed using flame atomic absorption spectroscopy (Perkin Elmer 2380, Norwalk, CT), as described previously [13].…”

Section: Animals and Dietsmentioning

confidence: 99%

Effect of Supplemental Dietary Zinc on the Mammalian Target of Rapamycin (mTOR) Signaling Pathway in Skeletal Muscle and Liver from Post-absorptive Mice

McClung

Tarr

Barnes

et al. 2007

Biol Trace Elem Res

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Zinc (Zn) is an essential trace element that functions in cellular signaling. The mammalian target of rapamycin (mTOR) regulates the initiation of protein synthesis. The objective of this study was to determine whether Zn could stimulate protein phosphorylation in the mTOR pathway in vivo. Mice (C57BL/6J, n = 30) were fed Zn marginal diets (ZM, 5 mg/kg) for 4 weeks, followed by fasting (F) and/or refeeding with ZM or Zn supplemental (300 mg/kg, ZS) diets for 3 or 6 h. Plasma insulin was greater (P < 0.05) in refed animals as compared to F animals. Protein phosphorylation was detected using multiplex analysis and Western blotting. Multiplex analysis indicated greater (P < 0.05) p70 S6 kinase (p70S6K) and glycogen synthase kinase 3 (GSK-3 alpha/beta) phosphorylation in livers from 6-h refed ZS animals as compared to F animals. Western blots indicated increased (P < 0.05) Akt (Ser 473) phosphorylation in skeletal muscle from animals refed ZS diets for 3 and 6 h as compared to F animals. The ZS diet affected phosphorylation of GSK-3 (alpha/beta) in liver, as 3-h ZS refed animals had greater (P < 0.01) phosphorylation than F animals. These findings indicate that Zn may contribute to the initiation of protein synthesis as a signaling molecule in vivo.

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Effects of dietary phytase on body weight gain, body composition and bone strength in growing rats fed a low-zinc diet

Cited by 23 publications

References 47 publications

Cytotoxicity of Silver Solder Employed in Orthodontics

Cytotoxicity of Silver Solder Employed in Orthodontics

Zinc bioavailability in different beans as affected by cultivar type and cooking conditions

Effect of Supplemental Dietary Zinc on the Mammalian Target of Rapamycin (mTOR) Signaling Pathway in Skeletal Muscle and Liver from Post-absorptive Mice

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