Supplemental Peri-Operative Oxygen and Incision Site Infection after Surgery for Perforated Peptic Ulcer: A Randomized, Double-Blind Monocentric Trial

Schietroma, Mario; Marina, CeciliaEmanuela; SantisGiuseppe, De; Carlei, Francesco; PessiaBeatrice,; AmicucciGianfranco,

doi:10.1089/sur.2013.132

Cited by 33 publications

(47 citation statements)

References 44 publications

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“…66 The risk of SSI infection was significantly lower in the 80% group compared to the 30% group with 48%. 66 Another significant decrease of the incidence of SSI was reported in the study of Bickel et al 73 70 Evaluation of 400 patients showed no significant difference between groups. 70 In addition three comparable studies evaluated whether 80% supplemental inspired oxygen during and for one to two hours after cesarean delivery would decrease SSI.…”

Section: Supplemental Inspired Oxygenmentioning

confidence: 81%

“…78,80 Schietroma et al again investigated the effect of supplemental inspired oxygen but this time in a population of 239 patients who underwent open surgery for perforated peptic ulcer. 66 The risk of SSI infection was significantly lower in the 80% group compared to the 30% group with 48%. 66 Another significant decrease of the incidence of SSI was reported in the study of Bickel et al 73 70 Evaluation of 400 patients showed no significant difference between groups.…”

Section: Supplemental Inspired Oxygenmentioning

confidence: 81%

“…Schietroma et al again investigated the effect of supplemental inspired oxygen but this time in a population of 239 patients who underwent open surgery for perforated peptic ulcer . The risk of SSI infection was significantly lower in the 80% group compared to the 30% group with 48% …”

Section: Resultsmentioning

confidence: 99%

“…Of these surgical procedures, five of the seven studies investigating inspired oxygen in gastrointestinal surgery had significant positive outcomes on SSI. 66,68,73,78,80 Despite these positive outcomes, the previous meta-analysis of Patel et al showed no evidence in reducing SSIs by the use of high inspired perioperative in abdominal surgery. 86 Also, in the meta-analysis of Klingel et al, no evidence is found that administration of high inspired oxygen would reduce the risk of SSIs in women undergoing cesarean section.…”

Section: Supplemental Inspired Oxygenmentioning

confidence: 99%

“…Sixteen studies regarding perioperative inspired oxygen therapy were included. 15,[66][67][68][69][70][71][72][73][74][75][76][77][78][79][80] All, except for two, 69,79 were randomized controlled trials and investigated the influence of high-concentration supplemental inspired oxygen on the incidence of SSIs in a variety of surgical procedures. Of these surgical procedures, five of the seven studies investigating inspired oxygen in gastrointestinal surgery had significant positive outcomes on SSI.…”

Section: Supplemental Inspired Oxygenmentioning

confidence: 99%

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Oxygen therapies and their effects on wound healing

Smet

Kroese

Menon

et al. 2017

Wound Repair Regeneration

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Oxygen is an important factor for wound healing. Although several different therapies investigated the use of oxygen to aid wound healing, the results of these studies are not unequivocal. This systematic review summarizes the clinical and experimental studies regarding different oxygen therapies for promoting wound healing, and evaluates the outcomes according the methodological details. A systematic literature search was conducted using Embase, Medline, Web of Science, Cochrane, PubMed publisher, and Google Scholar libraries. Clinical and experimental studies investigating oxygen for wound healing were selected. Included articles were categorized according to the kind of therapy, study design, and wound type. The methodological details were extracted and analyzed. Sixty-five articles were identified and divided in three different oxygen therapies: Local oxygen therapy, hyperbaric oxygen therapy, and supplemental inspired oxygen therapy. More than half of the included local oxygen and hyperbaric oxygen studies had one or more significant positive outcomes, 77 and 63%, respectively. Supplemental inspired oxygen therapy during gastrointestinal and vascular surgery was more likely to have a positive result than during other surgical interventions reducing surgical site infections. These many positive outcomes promote the use of oxygen treatment in the stimulation of wound healing. However, the lack of clinical studies and vast methodological diversity made it impossible to perform a proper comparison within and between the different therapies. Further randomized clinical studies are warranted to examine the value of these therapies, especially studies that investigate the more patient-friendly oxygen dressings and topical wound oxygen therapies. Also, to achieve more solid and consistent data, studies should use more standardized methods and subjects.

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Section: Supplemental Inspired Oxygenmentioning

confidence: 81%

Section: Supplemental Inspired Oxygenmentioning

confidence: 81%

Section: Resultsmentioning

confidence: 99%

Section: Supplemental Inspired Oxygenmentioning

confidence: 99%

Section: Supplemental Inspired Oxygenmentioning

confidence: 99%

See 3 more Smart Citations

Oxygen therapies and their effects on wound healing

Smet

Kroese

Menon

et al. 2017

Wound Repair Regeneration

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O₂ No Longer the Go₂: A Systematic Review and Meta‐Analysis Comparing the Effects of Giving Perioperative Oxygen Therapy of 30% FiO₂ to 80% FiO₂ on Surgical Site Infection and Mortality

2019

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Objective To determine the effects of perioperative high (80%) versus low (30%) fraction of inspired oxygen (FiO 2 ) on surgical site infection (SSI) and mortality in adult surgical patients. Background The routine use of high fraction perioperative oxygen in patients is ''standard of care'' and recommended by the World Health Organisation; however, whether there is truly any benefit to this therapy has been challenged by some authors. Questions have also been raised about the possibility of harm from oxygen therapy. Method Randomised control trials comparing high-to-low FiO 2 were located by searching MEDLINE, Embase, CENTRAL and Web of Science. The primary outcomes were SSI up to 15 days and up to any time point postoperatively and mortality up to 30 days. The data were analysed using random effects meta-analysis. Results Twelve studies involving 10,212 participants were included. At 15 days postoperatively, and at the longest point of post-operative follow-up, there was no statistically significant reduction in the risk of SSI when comparing patients who received a perioperative FiO 2 of 30% to those with an FiO 2 of 80% (RR 1.41, 95% CI 1.00-2.01, p 0.05 and RR 1.23, 95% CI 1.00-1.51, p 0.05). There was no statistically significant difference in mortality between the 30% FiO 2 and the 80% FiO 2 groups (RR 1.12, 95% CI 0.56-2.22, p 0.76). Conclusion This meta-analysis showed no statistically significant difference in post-operative SSI or mortality when comparing patients receiving an FiO 2 of 80% to those receiving an FiO 2 of 30%.

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Effects of intraoperative high versus low inspiratory oxygen fraction (FiO2) on patient's outcome: A systematic review of evidence from the last 20 years

Fasquel

Huet

Ozier

et al. 2020

Anaesthesia Critical Care & Pain Medicine

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Supplemental Peri-Operative Oxygen and Incision Site Infection after Surgery for Perforated Peptic Ulcer: A Randomized, Double-Blind Monocentric Trial

Abstract: Supplemental 80% FiO2 during and for 6 h after open surgery for PPU, which reduces post-operative SSI, should be considered part of ongoing quality improvement activities related to surgical care, with few risks to the patient and little associated cost.

Cited by 33 publications

References 44 publications

Oxygen therapies and their effects on wound healing

Oxygen therapies and their effects on wound healing

O₂ No Longer the Go₂: A Systematic Review and Meta‐Analysis Comparing the Effects of Giving Perioperative Oxygen Therapy of 30% FiO₂ to 80% FiO₂ on Surgical Site Infection and Mortality

Effects of intraoperative high versus low inspiratory oxygen fraction (FiO2) on patient's outcome: A systematic review of evidence from the last 20 years

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Supplemental Peri-Operative Oxygen and Incision Site Infection after Surgery for Perforated Peptic Ulcer: A Randomized, Double-Blind Monocentric Trial

Abstract: Supplemental 80% FiO2 during and for 6 h after open surgery for PPU, which reduces post-operative SSI, should be considered part of ongoing quality improvement activities related to surgical care, with few risks to the patient and little associated cost.

Cited by 33 publications

References 44 publications

Oxygen therapies and their effects on wound healing

Oxygen therapies and their effects on wound healing

O2 No Longer the Go2: A Systematic Review and Meta‐Analysis Comparing the Effects of Giving Perioperative Oxygen Therapy of 30% FiO2 to 80% FiO2 on Surgical Site Infection and Mortality

Effects of intraoperative high versus low inspiratory oxygen fraction (FiO2) on patient's outcome: A systematic review of evidence from the last 20 years

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Product

Resources

About

O₂ No Longer the Go₂: A Systematic Review and Meta‐Analysis Comparing the Effects of Giving Perioperative Oxygen Therapy of 30% FiO₂ to 80% FiO₂ on Surgical Site Infection and Mortality