Supine low-frequency power of heart rate variability reflects baroreflex function, not cardiac sympathetic innervation

Moak, Jeffrey P.; Goldstein, David S.; Eldadah, Basil A.; Saleem, Ahmed; Holmes, Courtney; Pechnik, Sandra; Sharabi, Yehonatan

doi:10.1016/j.hrthm.2007.07.019

Cited by 191 publications

(150 citation statements)

References 27 publications

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“…Further, the LF/HF ratio has been suggested to offer a measure of sympathovagal balance (Malliani et al 1994), but this theory has conflicting arguments (Berntson et al 1997;Eckberg, 1997). A recent study of Rahman et al (2011) concluded, and replicated previous findings (Moak et al 2007), that LFP power does not reflect cardiac sympathetic tone but may reflect the ability of baroreflexes to modulate cardiac autonomic outflows. In addition, in the recent study of Ng et al (2009), -adrenergic blockade did not affect LFP during immediate recovery after exercise.…”

Section: Frequency Domain Analysismentioning

confidence: 97%

Heart rate variability is related to training load variables in interval running exercises

Kaikkonen¹,

Hynynen

Mann

et al. 2011

Eur J Appl Physiol

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Section: Frequency Domain Analysismentioning

confidence: 97%

Heart rate variability is related to training load variables in interval running exercises

Kaikkonen¹,

Hynynen

Mann

et al. 2011

Eur J Appl Physiol

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“…High-frequency power relates to respiratory sinus arrhythmia and therefore to parasympathetic cardiovagal tone. [25] Consequently, the LF/HF ratio is considered by some investigators to mirror sympatho/vagal balance or to reflect sympathetic modulations. [26] Inability to increase LF/ HF ratio on tilt up in patients with PD indicates impaired sympathovagal balance.…”

Section: Discussionmentioning

confidence: 99%

Autonomic cardiovascular regulation in Parkinson's disease by head-up tilt test - A cross-sectional study

Jaipurkar¹,

Mohan²,

Tomar³

2018

Natl J Physiol Pharm Pharmacol

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Background: Autonomic failure is an integral component of Parkinson's disease (PD), and orthostatic hypotension (OH) is commonly observed in advanced cases of PD. OH may be the result of underlying cardiovascular autonomic dysfunction or adverse effect of antiparkinsonian drugs. Patients may be asymptomatic during the early stage of disease but may have underlying cardiovascular dysautonomia which becomes obvious on stress. Most of the earlier studies used morphological and functional methods to evaluate cardiovascular autonomic control but were unable to evaluate during dynamic conditions. Aims and Objectives: The aim of the study was to evaluate cardiovascular autonomic disturbances in patients with PD using head-up tilt table test (HUTT). The objective of the study was to compare the spectral profile of heart rate variability (HRV) and blood pressure (BP) to orthostatic challenges using HUTT in patients with PD with healthy individuals. Materials and Methods: In this cross-sectional study, we have recorded continuous lead II ECG along with BP every 2 min in patients with PD and control group during HUTT for 10 min in supine, 45 min in 70° tilt and again 10 min in supine position which were later analyzed using Biopac software for HRV. Results: Symptoms indicating autonomic nervous system dysfunction were present in 65% (20) patients with PD. Postural dizziness was present in 20% (6) patients. After 5 min of tilt-up, increase in HR in patients with PD was lower than in controls. There was no significant change in diastolic BP (DBP) on tilting-up in patients with PD while DBP significantly increased in controls on tilting-up from73 ± 9 mm Hg to 80±11 mm Hg (P < 0.00001). The low frequency (LF) was not significantly changed in patients with PD, and it increased significantly in controls from 3.05 (2.28 to 4.70) ms 2 to 3.73 (2.69-5.03) ms

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“…In the present study, the b/a increased pendent determinants of the c/a. Recently, the LF component has been proposed to reflect the baroreflex function rather than the cardiac sympathetic activity 13,14) . These findings suggest that a decrease in the c/a is associated with a reduced baroreflex response of the peripheral vasomotor activity and decreased cardiac parasympathetic tone.…”

Section: Discussionmentioning

confidence: 99%

Associations between the Autonomic Nervous System and the Second Derivative of the Finger Photoplethysmogram Indices

Kohjitani

Miyata

Iwase

et al. 2014

JAT

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A multivariate regression analysis showed that the LF, HF and heart rate were independent determinants of the c/a. Furthermore, the c/a values were significantly lower in the patients with hypertension, diabetes mellitus and hyperlipidemia than in those without these diseases, and a reduced c/a was significantly associated with increased serum triglyceride and total cholesterol concentrations. Conclusions: These findings suggest that a decrease in c/a is associated with a reduced baroreflex response of the peripheral vasomotor activity and a decreased cardiac parasympathetic activity. Furthermore, a decrease in c/a was found to be associated with atherosclerosis-based conditions, such as hypertension, diabetes mellitus and hyperlipidemia. J Atheroscler Thromb, 2014; 21:501-508.

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Supine low-frequency power of heart rate variability reflects baroreflex function, not cardiac sympathetic innervation

Abstract: LF power reflects baroreflex function, not cardiac sympathetic innervation.

Cited by 191 publications

References 27 publications

Heart rate variability is related to training load variables in interval running exercises

Heart rate variability is related to training load variables in interval running exercises

Autonomic cardiovascular regulation in Parkinson's disease by head-up tilt test - A cross-sectional study

Associations between the Autonomic Nervous System and the Second Derivative of the Finger Photoplethysmogram Indices

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