Associations between the Autonomic Nervous System and the Second Derivative of the Finger Photoplethysmogram Indices

Kohjitani, Atsushi; Miyata, Masaaki; Iwase, Yoko; Ohno, Sho; Tohya, Akina; Manabe, Yozo; Hashiguchi, Teruto; Sugiyama, Katsumi

doi:10.5551/jat.19877

Cited by 8 publications

(5 citation statements)

References 26 publications

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“…To resolve this issue, more physiological parameters that are relevant to arterial properties rather than PTT should be introduced to estimate BP in individuals with heart disease. For instance, useful features of the second derivative of PPG (SDPPG) could be potent candidates (Baek et al 2010), because the indices of SDPPG denote stiffness of large arteries, peripheral vascular resistance and vascular aging (Kohjitani et al 2014). Figure 6 shows the representative PPG waveform of one healthy subject and a patient diagnosed with congestive heart failure, in which the ratios of the absolute of the height of the 'b' wave and that of the 'd' wave to that of 'a' wave, namely the b:a and d:a ratios, could evaluate the arterial properties (Hashimoto et al 2002).…”

Section: Influence Of Heart Disease On Ptt-based Bp Estimationmentioning

confidence: 99%

Impact of heart disease and calibration interval on accuracy of pulse transit time–based blood pressure estimation

2016

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Continuous blood pressure (BP) measurement without a cuff is advantageous for the early detection and prevention of hypertension. The pulse transit time (PTT) method has proven to be promising for continuous cuffless BP measurement. However, the problem of accuracy is one of the most challenging aspects before the large-scale clinical application of this method. Since PTT-based BP estimation relies primarily on the relationship between PTT and BP under certain assumptions, estimation accuracy will be affected by cardiovascular disorders that impair this relationship and by the calibration frequency, which may violate these assumptions. This study sought to examine the impact of heart disease and the calibration interval on the accuracy of PTT-based BP estimation. The accuracy of a PTT-BP algorithm was investigated in 37 healthy subjects and 48 patients with heart disease at different calibration intervals, namely 15 min, 2 weeks, and 1 month after initial calibration. The results showed that the overall accuracy of systolic BP estimation was significantly lower in subjects with heart disease than in healthy subjects, but diastolic BP estimation was more accurate in patients than in healthy subjects. The accuracy of systolic and diastolic BP estimation becomes less reliable with longer calibration intervals. These findings demonstrate that both heart disease and the calibration interval can influence the accuracy of PTT-based BP estimation and should be taken into consideration to improve estimation accuracy.

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Section: Influence Of Heart Disease On Ptt-based Bp Estimationmentioning

confidence: 99%

Impact of heart disease and calibration interval on accuracy of pulse transit time–based blood pressure estimation

2016

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“…It is commonly known as a parameter for assessing arteriosclerosis, which is representative of severe functional arterial aging. Several previous studies have also reported that patients with any history of arteriosclerotic diseases, including hypertension, diabetes mellitus, and hypercholesterolemia, had higher SDPTG-AI values [2,7,27].…”

Section: Discussionmentioning

confidence: 85%

Variations in the Second Derivative of a Photoplethysmogram with Age in Healthy Korean Adults

Choi

Park

2022

IJERPH

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Second derivative of photoplethysmogram (SDPTG) indices correlate with aging and vascular health. The trend of SDPTG indices with age has not yet been studied in the Korean population. Various SDPTG indices were measured in 300 healthy Koreans (150 men and 150 women), aged 19–69 years, stratified into five age groups consisting of 60 people (30 men and 30 women) in each age group from their 20s to 60s. The values of the SDPTG indices clearly showed distinct variations with age in healthy Korean groups (p < 0.001 for all indices). b/a increased linearly with age (y = 0.0045x − 0.803), as did SDPTG aging index (SDPTG-AI) (y = 0.0162x − 1.1389). c/a decreased linearly with age (y = −0.0044x + 0.1017), as did d/a (y = −0.0062x + 0.034) and e/a (y = −0.001x + 0.2002). A significant sex difference was shown in b/a and e/a ratios and SDPTG-AI (p < 0.001 for all indices); women had a higher b/a ratio (−0.55 ± 0.14 versus −0.65 ± 0.13) and SDPTG-AI (−0.33 ± 0.3 versus −0.52 ± 0.33) and a lower e/a ratio (0.13 ± 0.06 versus 0.18 ± 0.07) than men. A linear regression model of diverse SDPTG indices was provided according to the age of healthy Koreans, which may be valuable in preventing diseases related to vascular conditions by estimating the degradation of arterial function.

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“…During exercise, both c/a and d/a were not detectable in either group. It has been reported that a reduced c/a was associated with a decreased baroreflex responses and with a reduced cardiac parasympathetic tone (Kohjitani et al, 2014 ). Moreover, the c/a was related to hypertension, diabetes mellitus and hyperlipidemia as well as elevated total cholesterol concentrations (Kohjitani et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported that a reduced c/a was associated with a decreased baroreflex responses and with a reduced cardiac parasympathetic tone (Kohjitani et al, 2014 ). Moreover, the c/a was related to hypertension, diabetes mellitus and hyperlipidemia as well as elevated total cholesterol concentrations (Kohjitani et al, 2014 ). In addition, some studies have reported that a decline in these parameters was associated with increased arterial stiffness or age (Rivas-Vilchis et al, 2007 ; Rozi et al, 2013 ).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Cardiorespiratory Function During Cardiopulmonary Exercise Testing in Untreated Hypertensive and Healthy Subjects

Zhang

Jiang

et al. 2018

Front. Physiol.

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Objective: This study aimed to compare differences in cardiorespiratory function between untreated hypertensive subjects (UHS) and healthy subjects (HS) during cardiopulmonary exercise testing (CPET). Additionally, it also aimed to explore the potential mechanisms of different exercise responses in cardiorespiratory function before, during and after CPET.Methods: Thirty subjects (15 UHS and 15 HS) were enrolled. Photoplethysmography (PPG), respiratory signal, and ECG were simultaneously collected while subjects were performing CPET. Fiducial points (a, b, c, d, e) were extracted from the second derivative of the PPG (SDPPG), and the ratios b/a, c/a, d/a, e/a, and (b-c-d-e)/a (named Aging Index, AGI) were calculated as markers of systolic and diastolic function. Additionally, respiratory rate was calculated and analyzed.Results:Before CPET, there were no significant differences in b/a, d/a, and AGI between two groups. However, after CPET, b/a (−0.9 ± 0.19 vs. −1.06 ± 0.19, p-value = 0.03) and AGI (−0.49 ± 0.75 vs. −1.15 ± 0.59, p-value = 0.011) of the UHS group were significantly higher than those of the HS. The d/a (−0.32 ± 0.24 vs. −0.14 ± 0.17, p-value = 0.024), and c/a (−0.33 ± 0.26 vs. −0.07 ± 0.19, p-value = 0.004) were significantly lower in UHS than those in HS. In contrast, before CPET, e/a (0.22 ± 0.11 vs. 0.32 ± 0.09, p-value = 0.007) in UHS was significantly lower than that in HS, while after CPET there was no significant difference between the two groups in this variable. In addition, during CPET, AGI (p-value = 0.003), and respiratory rate (p-value = 0.000) in UHS were significantly higher in comparison with before CPET.Conclusions: Different exercise responses showed the differences of cardiorespiratory function between UHS and HS. These differences not only can highlight the CV risk of UHS, but also can predict the appearance of arterial stiffness in UHS. Additionally, during CPET, significant differences in AGI, autonomic nervous function and respiratory activity assessed by respiratory rate were found between the two groups in comparison with before CPET.

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Associations between the Autonomic Nervous System and the Second Derivative of the Finger Photoplethysmogram Indices

Cited by 8 publications

References 26 publications

Impact of heart disease and calibration interval on accuracy of pulse transit time–based blood pressure estimation

Impact of heart disease and calibration interval on accuracy of pulse transit time–based blood pressure estimation

Variations in the Second Derivative of a Photoplethysmogram with Age in Healthy Korean Adults

Evaluation of Cardiorespiratory Function During Cardiopulmonary Exercise Testing in Untreated Hypertensive and Healthy Subjects

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