Superselective Intraarterial Infusion Chemotherapy Using High-Dose Cisplatin for Advanced Paranasal Sinus Carcinomas

Yokoyama, Junkichi; Ikeda, Kousuke; Koiwa, Tetuo; 幸夫, 香取; Hashimoto, Sho

doi:10.7248/jjrhi1982.39.4_365

Cited by 5 publications

(2 citation statements)

References 7 publications

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“…High dose intra-arterial or i.v. chemotherapy has received significant attention for the treatment of extensive paranasal sinus neoplasia in man but, to the authors' knowledge, protocols have not been established in the horse (Zielke-Temme et al 1980;Moseley et al 1981;Lee et al 1986;Yokoyama et al 1999;Papadimitrakopoulou et al 2003).…”

Section: Fig 6: Transverse Computed Tomogram Of An 8-year-old Hannovementioning

confidence: 99%

Early diagnosis may hold the key to the successful treatment of nasal and paranasal sinus neoplasia in the horse

Witte

Perkins

2011

Equine Veterinary Education

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Summary Intrasinus neoplasia remains a rare but difficult condition to diagnose and treat in the horse, comprising approximately 8–19% of sinonasal disorders. There are, however, only a few case series upon which to base an approach to diagnosis and management (Cotchin 1967, 1977; Madewell et al. 1976; Stunzi and Hauser 1976; Sundberg et al. 1977; Priester and McKay 1980; Boulton 1985; Hilbert et al. 1988; Dixon and Head 1999; Head and Dixon 1999; Tremaine and Dixon 2001a,b). Squamous cell carcinoma (SCC) is the most common neoplasm observed in the equine paranasal sinuses. Evidence from other species would indicate that early recognition of SCC is crucial to the success of treatment and the ideal treatment remains complete excision with margins. Sinus involvement generally precludes this and we must often settle for surgical debulking, with or without adjunctive radio‐ or chemotherapy. In horses, as in other species, early recognition is difficult because clinical signs are nonspecific. Treatment is, therefore, often not attempted due to the extensive nature of lesions at presentation and the limited surgical access. The accompanying article by Kowalczyk et al. (2011) showed how 3‐dimensional (3D) imaging can identify the hallmark changes associated with aggressive neoplasia in the equine sinuses (Kowalczyk et al. 2011). The value of computed tomography (CT) and magnetic resonance imaging (MRI) lies in noninvasive early diagnosis as well as lesion monitoring post intervention. Where CT can be performed with the horse in the standing position, avoidance of general anaesthesia offers further value, especially as standing surgical techniques now allow thorough, minimally invasive evaluation and biopsy of the equine sinuses. In combination, standing CT and minimally invasive sinus surgery allow accurate and early diagnosis and monitoring of disease progression, opening the door for advances in surgical and adjunctive treatments for this complex condition.

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Section: Fig 6: Transverse Computed Tomogram Of An 8-year-old Hannovementioning

confidence: 99%

Early diagnosis may hold the key to the successful treatment of nasal and paranasal sinus neoplasia in the horse

Witte

Perkins

2011

Equine Veterinary Education

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“…Yokoyama et al (55) first reported RADPLAT in Japan in 1998. They reported that large tumours were resolved using this therapy and high-dose weekly cisplatin infusion did not cause any serious side effects, which surprised Japanese head and neck oncologists.…”

Section: Superselective Arterial Infusion Of High-dose Cisplatinmentioning

confidence: 99%

Intra-arterial chemoradiotherapy for head and neck cancer

Homma¹,

Onimaru²,

Matsuura³

et al. 2015

Jpn. J. Clin. Oncol.

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Intra-arterial chemotherapy has been used to treat localized malignant neoplasms in patients with head and neck cancer for over 50 years as the head and neck region is particularly well suited to regional chemotherapy. Early intra-arterial chemotherapy did not prove its efficacy. In addition, the additional complications associated with establishing and maintaining arterial access have further dampened enthusiasm for this approach. Subsequent significant advances in vascular radiology techniques and the development of new devices, such as fluoroscopy units and angiographic catheters, have made possible safe, accurate and repeated superselective intra-arterial chemotherapy. Intra-arterial infusion of high-dose cisplatin with systemic neutralization by intravenous sodium thiosulfate (RADPLAT) is a theoretically attractive approach to the treatment of advanced head and neck cancer. However, a Dutch trial comparing intra-arterial and intravenous chemoradiotherapy for advanced head and neck cancer showed that RADPLAT was not superior to intravenous chemoradiotherapy. Therefore, further investigation of RADPLAT, including the refinement of the indications for its application, is needed.

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