Superparamagnetic nanoparticles for biomedical applications: Possibilities and limitations of a new drug delivery system

Neuberger, Thomas; Schöpf, Bernhard; Hofmann, Heinrich; Hofmann, Margarethe; Rechenberg, Brigitte von

doi:10.1016/j.jmmm.2005.01.064

Cited by 1,583 publications

(1,008 citation statements)

References 92 publications

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“…Due to their unique magnetic properties, superparamagnetic iron oxide nanoparticles (SPIONs) are very promising materials for diagnostic and therapeutic biomedical applications [1][2][3]. SPIONs are used, e.g., as contrast agents in magnetic resonance imaging (MRI), where they enhance the local magnetic field, thereby improving the proton magnetic resonance signals [4].…”

Section: Introductionmentioning

confidence: 99%

A quantitative study of particle size effects in the magnetorelaxometry of magnetic nanoparticles using atomic magnetometry

Dolgovskiy

Lebedev

Colombo

et al. 2015

Journal of Magnetism and Magnetic Materials

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The discrimination of immobilised superparamagnetic iron oxide nanoparticles (SPIONs) against SPIONs in fluid environments via their magnetic relaxation behaviour is a powerful tool for bio-medical imaging.Here we demonstrate that a gradiometer of laser-pumped atomic magnetometers can be used to record accurate time series of the relaxing magnetic field produced by pre-polarised SPIONs. We have investigated dry in vitro maghemite nanoparticle samples with different size distributions (average radii ranging from 14 to 21 nm) and analysed their relaxation using the Néel-Brown formalism. Fitting our model function to the magnetorelaxation (MRX) data allows us to extract the anisotropy constant K and the saturation magnetisation M S of each sample. While the latter was found not to depend on the particle size, we observe that K is inversely proportional to the (time-and size-) averaged volume of the magnetised particle fraction. We have identified the range of SPION sizes that are best suited for MRX detection considering our specific experimental conditions and sample preparation technique.

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Section: Introductionmentioning

confidence: 99%

A quantitative study of particle size effects in the magnetorelaxometry of magnetic nanoparticles using atomic magnetometry

Dolgovskiy

Lebedev

Colombo

et al. 2015

Journal of Magnetism and Magnetic Materials

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“…2,3 Surface functionalization strategies have been established during recent years using standard bioconjugation techniques 4 , supramolecular or bioorthogonal chemistry 5 , or nanoparticles (NPs) such as gold 6 , which are almost readymade for coupling procedures due to their particular chemistry. Despite significant progress in the field, surface functionalization is usually achieved in a tedious process by adapting typical synthesis parameters such as reaction time, concentration or pH.…”

Section: Introductionmentioning

confidence: 99%

Magnetic microreactors for efficient and reliable magnetic nanoparticle surface functionalization

et al. 2014

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Microreactors have attracted wide attention in the nano-and biotechnology field because they offer many advantages over standard liquid phase reactions. We report the development of a magnetic microreactor for reliable, fast and efficient surface functionalization of superparamagnetic iron oxide nanoparticles (SPIONs). A comprehensive study is described of the development process in terms of setup, loading capacity and efficiency. We have performed experimental and computational studies in order to evaluate the trapping efficiencies, maximum loading capacity and magnetic alignment of the nanoparticles. The results show that capacity and trapping efficiencies are directly related to the flow rate, elution time and reactor type. Based on our results and the developed magnetic microreactor, we describe a model multistep surface derivatization procedure of SPIONs.

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“…For example, magnetic nanoparticles have recently received much attention due to their potential application in clinical cancer treatment, [158][159][160][161][162] targeted drug delivery [163][164][165] and MRI contrast agents. 166,167 However, despite the useful functionalities that might derive from metal nanoparticle systems, the lack of targeting strategies has limited their application to locoregional disease.…”

Section: Future Applicationsmentioning

confidence: 99%

Transductional targeting of adenovirus vectors for gene therapy

2006

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Superparamagnetic nanoparticles for biomedical applications: Possibilities and limitations of a new drug delivery system

Cited by 1,583 publications

References 92 publications

A quantitative study of particle size effects in the magnetorelaxometry of magnetic nanoparticles using atomic magnetometry

A quantitative study of particle size effects in the magnetorelaxometry of magnetic nanoparticles using atomic magnetometry

Magnetic microreactors for efficient and reliable magnetic nanoparticle surface functionalization

Transductional targeting of adenovirus vectors for gene therapy

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