Superparamagnetic iron oxide nanoparticles for in vivo molecular and cellular imaging

Abstract

In the last decade, the biomedical applications of nanoparticles (NPs) (e.g. cell tracking, biosensing, magnetic resonance imaging (MRI), targeted drug delivery, and tissue engineering) have been increasingly developed. Among the various NP types, superparamagnetic iron oxide NPs (SPIONs) have attracted considerable attention for early detection of diseases due to their specific physicochemical properties and their molecular imaging capabilities. A comprehensive review is presented on the recent advances in the development of in vitro and in vivo SPION applications for molecular imaging, along with opportunities and challenges.

Environmental implications and applications of engineered nanoscale magnetite and its hybrid nanocomposites: A review of recent literature

“…The maximum sorption capacities of fungus-Fe3O4 are for Sr(II) and U(VI) at pH 5.0, and Th(IV) at pH 3.0 [356]. Four new MNP containing different chelating groups as ester, amide, and azacrown moieties at the lower rim of calix [4]arenes have been prepared by the reaction of formylated calix [4]arenes and amino propyl modified MNPs (APTMS-MNP). MNPs containing picolinamide units exhibit superior and more efficient extraction percentage for uranium ions at lower pH values [357].…”

“…It behaves as superparamagnetic as the particle size is reduced to a few nanometers. MNPs have been used for biomedical applications such as biosensing, cell tracking, tissue engineering, magnetic resonance imaging (MRI)/optical multimodal imaging, targeted drug delivery, and hyperthermia therapeutic cancer treatment [1][2][3][4][5][6][7][8]. Whereas ferrite system CoFe2−xAlxO4 (x = 0.0, 0.3, 0.7 and 1.0) have been synthesized through the co-precipitation technique to form a nano-size (20-63 nm) single spinel phase [22].…”

Anticancer activity of Ru- and Os(arene) compounds of a maleimide-functionalized bioactive pyridinecarbothioamide ligand

“…These involve the use of macromolecular carrier systems, such as nanoparticles, micelles and proteins, all of which have been established to be efficacious in delivering pharmacophores [12][13][14][15][16][17][18][19]. Macromolecules and nanoparticles can extravasate into tumor tissue via leaky vessels exploiting the enhanced permeability and retention (EPR) effect, which is related to an increased permeability of macromolecules from the blood vessels into tumors [20][21][22][23].…”

Superparamagnetic iron oxide nanoparticles for MR imaging of pancreatic cancer: Potential for early diagnosis through targeted strategies

“…8 Finally, SPION exhibit large surface areas, making them favorable for versatile surface functionalization and conjugation of biomolecules. 9 …”