Superoxide Dismutase and Nicotinamide Adenine Dinucleotide Phosphate

Mohelníková-Duchoňová, Beatrice; Marsakova, Lenka; Vrána, David; Holcátová, Ivana; Ryska, Miroslav; Šmerhovský, Zdeněk; Slámová, Alena; Schejbalová, Miriam; Souček, Pavel

doi:10.1097/mpa.0b013e3181f74ad7

Cited by 19 publications

(11 citation statements)

References 31 publications

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“…To date, there has been a limited number of epidemiologic studies that investigate pancreatic cancer risk associated with polymorphisms in antioxidant genes, glucose metabolism genes, or carcinogen metabolism genes. Among antioxidant genes, pancreatic cancer has shown null 16, 17 and increased 18 associations with SNPs of manganese superoxide dismutase ( SOD2) with some observed significant interactions with diabeties 19 , and dietary intake of vitamin E 19 , lutein/zeaxanthin, lycopene, α-carotene, and α-tocopherol. 20 Among glucose metabolism genes, a SNP in glucokinase ( GCK) has been associated with better overall survival.…”

Section: Introductionmentioning

confidence: 99%

Polymorphisms in Metabolism/Antioxidant Genes May Mediate the Effect of Dietary Intake on Pancreatic Cancer Risk

Jansen¹,

Robinson²,

Bamlet³

et al. 2013

Pancreas

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Objectives A source of variation for inconsistent dietary-pancreatic cancer associations may be individuals carrying constitutional metabolism/antioxidant gene variants differentially benefit compared to homozygous individuals. Seventy-six tag SNPs were genotyped in thirteen candidate genes to test differential associations with pancreatic adenocarcinoma. Methods A clinic-based case-control design was used to rapidly ascertain 251 cases and 970 frequency matched controls who provided blood samples and completed a 144-item food frequency questionnaire. SNPs were evaluated using a dominant genetic model and dietary categories split on controls’ median intake. Logistic regression was used to calculate odds ratios and 95% confidence intervals, adjusted for potential confounders. Results Significant increased associations (Bonferroni corrected P ≤ 0.0007) were observed for carriers of ≥ 1 minor allele for rs3816257 (glucosidase, alpha; acid [GAA]) and lower intake of deep-yellow vegetables (1.90[1.28,2.83]); and carriers of no minor allele for rs12807961 (catalyase [CAT]) and high total grains intake (2.48[1.50,4.09]) while those with ≥ 1 minor allele had a decreasing slope (across grains). The reference group was no minor alleles with low dietary intake. Conclusions Inter-individual variation in metabolism/antioxidant genes could interact with dietary intake to influence pancreatic cancer risk.

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Section: Introductionmentioning

confidence: 99%

Polymorphisms in Metabolism/Antioxidant Genes May Mediate the Effect of Dietary Intake on Pancreatic Cancer Risk

Jansen¹,

Robinson²,

Bamlet³

et al. 2013

Pancreas

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“…We genotyped 208 PDAC cases and 381 controls from the Czech Republic in the discovery phase1314. Three SNPs (rs2504938, rs9364554, and rs2457571) were significantly associated with PDAC risk in at least one of the genetic models tested (Table 2).…”

Section: Resultsmentioning

confidence: 99%

“…The controls were included into the study under the condition that the difference in their age was not larger than 5 years from cases recruited in the same period. Basic epidemiological data on all participants (personal history, smoking and drinking history, physical activity, occupational and nutritional information) were collected (for case and control recruitment criteria see refs 13,14). The validation phase consisted of 1,273 cases and 3,466 controls enrolled into the PANcreatic Disease ReseArch (PANDoRA) consortium from three other European countries (Germany, Italy, and Poland).…”

Section: Methodsmentioning

confidence: 99%

SLC22A3 polymorphisms do not modify pancreatic cancer risk, but may influence overall patient survival

Mohelníková-Duchoňová

Strouhal

Hughes

et al. 2017

Sci Rep

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Expression of the solute carrier (SLC) transporter SLC22A3 gene is associated with overall survival of pancreatic cancer patients. This study tested whether genetic variability in SLC22A3 associates with pancreatic cancer risk and prognosis. Twenty four single nucleotide polymorphisms (SNPs) tagging the SLC22A3 gene sequence and regulatory elements were selected for analysis. Of these, 22 were successfully evaluated in the discovery phase while six significant or suggestive variants entered the validation phase, comprising a total study number of 1,518 cases and 3,908 controls. In the discovery phase, rs2504938, rs9364554, and rs2457571 SNPs were significantly associated with pancreatic cancer risk. Moreover, rs7758229 associated with the presence of distant metastases, while rs512077 and rs2504956 correlated with overall survival of patients. Although replicated, the association for rs9364554 did not pass multiple testing corrections in the validation phase. Contrary to the discovery stage, rs2504938 associated with survival in the validation cohort, which was more pronounced in stage IV patients. In conclusion, common variation in the SLC22A3 gene is unlikely to significantly contribute to pancreatic cancer risk. The rs2504938 SNP in SLC22A3 significantly associates with an unfavorable prognosis of pancreatic cancer patients. Further investigation of this SNP effect on the molecular and clinical phenotype is warranted.

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“…A significant rise in oxidative stress and low levels of antioxidants has been observed in breast cancer patients with a smoking history [ 27 ]. However, smoking and alcohol consumption did not modify the effect of the oxidative stress-modifying genes in pancreatic cancer [ 28 ], and no significant interaction was observed between pack-years of smoking and oxidative stress-related genetic polymorphisms in colorectal cancer [ 29 ]. In our study, we found smoking and drinking history had no correlation with the parameters of oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Total Oxidant/Antioxidant Status in Sera of Patients with Esophageal Cancer

Huang

Feng

et al. 2017

Med Sci Monit

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BackgroundOxidative stress parameters such as total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) have been studied in breast, thyroid, and simple esophageal cancers (EC). We evaluated these parameters in patients with EC and analyzed their correlations with treatment outcomes.Material/MethodSerum TOS, TAS, and OSI in 92 patients with EC at different clinical stages and in 64 healthy people (controls) were measured.ResultsSerum TOS, TAS, and OSI were significantly different between patients with EC and healthy controls (all p<0.001); however, there were no significant differences across different clinical stages (all p>0.05). These factors are not correlated with smoking or drinking history (all p>0.05). Patients with EC with higher TOS and OSI and lower TAS had better responses to chemotherapy and/or radiotherapy, but there was no significant correlation with different responses (all p>0.05). In a receiver operating characteristic curve analysis comparing patients with EC with healthy controls, the Youden indices were 0.391, 0.886, and 1, respectively.ConclusionsSerum TOS, TAS, and OSI were significantly different between patients with EC and healthy controls. In patients with EC, these factors were not correlated with smoking or drinking history or with clinical stage. Patients with EC with higher TOS and OSI and lower TAS had a trend towards better outcomes but it did not reach significance. Serum TOS and OSI are potential diagnostic biomarkers that can be used to identify cases of EC.

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Superoxide Dismutase and Nicotinamide Adenine Dinucleotide Phosphate

Abstract: The first European study of the SOD2, SOD3, NQO1, and NQO2 roles in pancreatic cancer etiology did not find significant associations. Despite this observation, other populations with different lifestyle(s) may be at risk and should be further studied.

Cited by 19 publications

References 31 publications

Polymorphisms in Metabolism/Antioxidant Genes May Mediate the Effect of Dietary Intake on Pancreatic Cancer Risk

Polymorphisms in Metabolism/Antioxidant Genes May Mediate the Effect of Dietary Intake on Pancreatic Cancer Risk

SLC22A3 polymorphisms do not modify pancreatic cancer risk, but may influence overall patient survival

Total Oxidant/Antioxidant Status in Sera of Patients with Esophageal Cancer

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