Polymorphisms in Metabolism/Antioxidant Genes May Mediate the Effect of Dietary Intake on Pancreatic Cancer Risk

Abstract

Objectives A source of variation for inconsistent dietary-pancreatic cancer associations may be individuals carrying constitutional metabolism/antioxidant gene variants differentially benefit compared to homozygous individuals. Seventy-six tag SNPs were genotyped in thirteen candidate genes to test differential associations with pancreatic adenocarcinoma. Methods A clinic-based case-control design was used to rapidly ascertain 251 cases and 970 frequency matched controls who provided blood samples and completed a 144-item food frequency questionnaire. SNPs were evaluated using a dominant genetic model and dietary categories split on controls’ median intake. Logistic regression was used to calculate odds ratios and 95% confidence intervals, adjusted for potential confounders. Results Significant increased associations (Bonferroni corrected P ≤ 0.0007) were observed for carriers of ≥ 1 minor allele for rs3816257 (glucosidase, alpha; acid [GAA]) and lower intake of deep-yellow vegetables (1.90[1.28,2.83]); and carriers of no minor allele for rs12807961 (catalyase [CAT]) and high total grains intake (2.48[1.50,4.09]) while those with ≥ 1 minor allele had a decreasing slope (across grains). The reference group was no minor alleles with low dietary intake. Conclusions Inter-individual variation in metabolism/antioxidant genes could interact with dietary intake to influence pancreatic cancer risk.

Association Between Catalase Gene Polymorphisms and Risk of Chronic Hepatitis B, Hepatitis B Virus-Related Liver Cirrhosis and Hepatocellular Carcinoma in Guangxi Population

“…Genetic variations in the CAT enzyme may modulate disease risk. 11 Several studies have suggested that CAT polymorphisms might be associated with a risk of various cancers such as breast cancer, 20 cervical cancer, 21 prostate cancer, 22 pancreatic cancer, 23 and colorectal cancer. 24 …”

“…Several research have investigated the association between the CAT SNPs rs1001179, rs769217, and rs7943316 polymorphisms and the risk of various cancers such as breast cancer, 20 cervical cancer, 21 prostate cancer, 22 pancreatic cancer, 23 and colorectal cancer 24 in various races. Three studies to date have examined the influence of CAT polymorphism on the risk of HCC.…”

The impact of dietary fibres on the physiological processes governing small intestinal digestive processes

“…European Project, Alexander, under the Seventh European Community Framework Programme (Grant Agreement Number 280761) 53.9 c, 4, α (K. Ikeda & Kusano, 1983) Oberg, et al, 2011;Jansen, Robinson, Stolzenberg-Solomon, Bamlet, Tan, Cunningham, et al, 2013) Case-control study with 532 cases of pancreatic cancer Adjusted OR of 0.60 (0.31-1.2) for ≥2 servings of whole grains/day versus 1 for <1 serving/day Frequency of consumption of brown rice and tortillas was negatively associated with OR while frequency of (Chan, Wang, & Holly, 2007) oatmeal/oat bran were positively associated with OR. Case-control study with 186 cases of pancreatic cancer Adjusted OR of 0.52 (0.21-1.30) for highest quartile of fibre intake versus 1 for lowest No significant trend also noted for association of frequency of fruit and vegetable consumption and OR (J.…”

An Overview of Genetic Changes and Risk of Pancreatic Ductal Adenocarcinoma

“…The group of increasing risk changes includes catalase ( CAT ) and GSTP1 , while to those with reducing character belongs glucosidase alpha acid ( GAA ), UGT2B4 (UDP-glucuronosyltransferase 2 family, polypeptideB4) and MT1E (metallothionein 1E) 48.…”