Association Between Catalase Gene Polymorphisms and Risk of Chronic Hepatitis B, Hepatitis B Virus-Related Liver Cirrhosis and Hepatocellular Carcinoma in Guangxi Population

Liu, Yanqiong; Xie, Li; Zhao, Jianping; Huang, Xiuli; Song, Liuying; Luo, Jingrong; Ma, Liping; Li, Shan; Qin, Xue

doi:10.1097/md.0000000000000702

Cited by 35 publications

(52 citation statements)

References 36 publications

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“…The mechanisms of gender difference in this study are still unknown. However, some reports indicated that different dietary habits and lifestyle choices (such as smoking and drinking) between male and female patients would somehow suggest that the male subgroup may be especially susceptible to cancer [28,36]. In addition, we found that the association between carriers of the PIN1 gene rs2233679 CT genotype and increased risk of HCC was more pronounced in ever-drinkers (OR= 3.98, 95 % CI=1.02-15.57).…”

Section: Discussionmentioning

confidence: 58%

“…Genomic DNA was extracted from leukocytes by using the proteinase K digestion and phenol-chloroform extraction method, which was reported by Liu et al [28]. Genotyping of the PIN1 gene polymorphisms, rs2233678, rs2233679, and rs2233682, was performed using the polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) assay as described by You et al [22].…”

Section: Dna Extraction and Snp Genotypingmentioning

confidence: 99%

“…These cases were consecutively recruited from the hospital beginning in April 2014 and ending in October 2014. In this study, the diagnosis criteria of HBVrelated HCC were described as follows [28][29][30]: (1) the 254 HBV-related HCC patients were all confirmed to have been infected with HBV for at least 6 months and (2) the HCC was diagnosed based on pathological confirmation (cytological or histological findings) and/or, for the liver, at least one positive finding on magnetic resonance imaging (MRI), computed tomography (CT) or ultrasonography, and/or elevated serum alpha fetoprotein (AFP) levels >400 ng/ml for 1 month. The selection criteria for the cancer-free controls included no personal or family history of cancer, being negative for HBV markers, and no clinical evidence of hepatic disease.…”

Section: Study Populationmentioning

confidence: 99%

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PIN1 genetic polymorphisms and the susceptibility of HBV-related hepatocellular carcinoma in a Guangxi population

Huang

Lao

et al. 2015

Tumor Biol.

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Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 (PIN1) plays a critical role in different signaling pathways, cell cycle progression and proliferation, and gene expression, and it has been found to overexpress in many tumor tissues. Recently, researchers have found that PIN1 gene polymorphisms may alter the function of protein and be associated with the risk of cancer. The present study analyzed three common polymorphisms in promoter regions (rs2233678 and rs2233679) and in exon2 (rs2233682) of the PIN1 gene in 254 patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) and 235 healthy controls in a Guangxi study population to determine whether any relationship exists between the polymorphisms and the risk of HBV-related HCC. The results revealed that the rs2233679 TT genotype was associated with increased risk of HCC with HBV infection [odds ratio (OR) = 2.04, 95 % confidence interval (95 % CI) = 1.13-3.69, p = 0.019]. This association was stronger in men than in women (OR = 2.17, 95 % CI = 1.09-4.34, p = 0.028) as well as in men 50 years of age and older (OR = 3.91, 95 % CI = 1.29-11.80, p = 0.016); moreover, for alcohol drinkers, being a carrier of the PIN1 rs2233679 CT genotype had a moderately increased risk of HCC (OR = 3.98, 95 % CI = 1.02-15.57, p = 0.047). In contrast, people carrying the rs2233682 GA genotype and A alleles were 0.23 times more likely to develop HCC (OR = 0.23, 95 % CI = 0.06-0.87, p = 0.031 and OR = 0.23, 95 % CI = 0.06-0.87, p = 0.030). No such associations were found in the PIN1 rs2233678 polymorphisms between the HBV-related HCC cases and the controls. In addition, the haplotype GCA was found to be a high protection factor for HCC with HBV infection (OR = 0.14, 95 % CI = 0.03-0.62, p = 0.003). In conclusion, this study's findings suggest that the PIN1 rs2233679 TT genotype, the rs2233682GA genotype, and A alleles might be associated with the HBV-related HCC in a Guangxi study population.

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Section: Discussionmentioning

confidence: 58%

Section: Dna Extraction and Snp Genotypingmentioning

confidence: 99%

Section: Study Populationmentioning

confidence: 99%

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PIN1 genetic polymorphisms and the susceptibility of HBV-related hepatocellular carcinoma in a Guangxi population

Huang

Lao

et al. 2015

Tumor Biol.

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“…Although this was unexpected, previous research has reported conflicting results regarding the impact of this SNP on various health conditions. Some studies show that the minor T allele is protective against diabetic neuropathy, acoustic neuroma, and later presentation of neurological manifestations of Wilson's disease [34–37], while other studies report an increase risk for breast and prostate cancer [93,94], chronic hepatitis B [95], alcohol dependency [96], ulcerative colitis [97], and asthma [98,99]. Additional research investigations have reported no association between CAT and sporadic Alzheimer's disease [100], hypertension [101], and depression [102].…”

Section: Discussionmentioning

confidence: 99%

Vulnerability of white matter tracts and cognition to the SOD2 polymorphism: A preliminary study of antioxidant defense genes in brain aging

Salminen

Schofield

Pierce

et al. 2017

Behavioural Brain Research

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Oxidative stress is a key mechanism of the aging process that can cause damage to brain white matter and cognitive functions. Polymorphisms in the superoxide dismutase 2 (SOD2) and catalase (CAT) genes have been associated with abnormalities in antioxidant enzyme activity in the aging brain, suggesting a risk for enhanced oxidative damage to white matter and cognition among older individuals with these genetic variants. The present study compared differences in white matter microstructure and cognition among 96 older adults with and without genetic risk factors of SOD2 (rs4880) and CAT (rs1001179). Results revealed higher radial diffusivity in the anterior thalamic radiation among SOD2 CC genotypes compared to CT/TT genotypes. Further, the CC genotype moderated the relationship between the hippocampal cingulum and processing speed, though this did not survive multiple test correction. The CAT polymorphism was not associated with brain outcomes in this cohort. These results suggest that the CC genotype of SOD2 is an important genetic marker of suboptimal brain aging in healthy individuals.

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“…[12] Oxidative stress can cause an imbalanced antioxidant defense system and an enhanced production of reactive oxygen species (ROS). [1314] ROS can induce severe DNA damage. [15] These DNA alterations, which activate proto-oncogenes and inactivate tumor suppressor genes, could contribute to the induction, promotion and progression of cancer in the oxidative stress affected organs.…”

Section: Introductionmentioning

confidence: 99%

Role of superoxide dismutase in hepatitis B virus-related hepatocellular carcinoma

Zhang

Rong

et al. 2016

J Res Med Sci

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Background:Reactive oxygen species (ROS) play important roles in hepatocarcinogenesis. Superoxide dismutase (SOD) is involved in the repair of ROS. Serum alpha-fetoprotein (AFP) is the “golden marker” for diagnosing hepatocellular carcinoma (HCC), and one major shortcoming of its use is that it is insensitive for the early detection of HCC. Therefore, we evaluated serum SOD levels and their association with AFP in hepatitis B virus (HBV)-related HCC.Materials and Methods:A total of 279 subjects were divided into three groups: 99 HBV patients with HCC, 73 HBV patients without HCC, and 107 sex- and age-matched healthy controls. Serum levels of SOD were assayed using colorimetry, while AFP levels were measured by electrochemiluminescence immunoassay.Results:A highly significant elevation was found in AFP in HBV-with HCC patients compared to HBV-without HCC patients and control subjects (P < 0.001). Alternatively, serum SOD levels were significantly decreased in patients with HCC compared to HBV patients without HCC and healthy controls (P < 0.001). Furthermore, serum SOD was negatively correlated with AFP (r = −0.505, P < 0.001) in HBV-with HCC patients.Conclusion:SOD and AFP might be simultaneously evaluated to improve the HCC detection rate.

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Association Between Catalase Gene Polymorphisms and Risk of Chronic Hepatitis B, Hepatitis B Virus-Related Liver Cirrhosis and Hepatocellular Carcinoma in Guangxi Population

Abstract: Supplemental Digital Content is available in the text

Cited by 35 publications

References 36 publications

PIN1 genetic polymorphisms and the susceptibility of HBV-related hepatocellular carcinoma in a Guangxi population

PIN1 genetic polymorphisms and the susceptibility of HBV-related hepatocellular carcinoma in a Guangxi population

Vulnerability of white matter tracts and cognition to the SOD2 polymorphism: A preliminary study of antioxidant defense genes in brain aging

Role of superoxide dismutase in hepatitis B virus-related hepatocellular carcinoma

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