Superoxide Dismutase Activity in Male and Female Patients of Different Age with Moderate COVID-19

Семенова, Н. В.; Rychkova, L. V.; Darenskaya, M. A.; Колесников, С. И.; Nikitina, O. A.; Петрова, А. Г.; Vyrupaeva, E. V.; Колесникова, Л. И.

doi:10.1007/s10517-022-05491-6

Cited by 20 publications

(11 citation statements)

References 15 publications

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“…In our study, SOD was decreased in the elderly subjects, but some observational studies suggested that high SOD levels are associated with decreased mortality (Kalmar and Greensmith, 2009). Results of some scientists concluded that women had greater SOD activity than men, which is perhaps one of the striking findings Semenova et al, 2022). However, the mechanism of differences in levels of SOD between males and females remains unclear, but possible reasons include differences in metabolic rates, leading to different levels of oxidative damage.…”

Section: Discussionmentioning

confidence: 45%

Potential Role of Heat Shock Proteins 60, 70, and 90 in the Aging Among Population of Punjab-Pakistan

Riaz

NOREEN

Qaiser

et al. 2023

Biol Clin Sci Res J

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Aging can be characterized as the collision of cellular and organ-destructive processes over the years with actions that maintain homeostasis, vitality, and longevity. The current study was based on an assessment of various indicators of stress, Heat shock proteins and antioxidants in elderly subjects to identifying their significance in ageing. It was aimed to increase the heat shock proteins, decreased antioxidants and vitamins responsible for ageing. A total of 100 individuals were recruited in the current study consisting of 50 young control and 50 older people. The significance of HSPs (60, 70, 90) and oxidative and antioxidant markers, were analyzed through laboratory tests and ELIZA kits using serum samples. The results were evaluated through an independent t-test in SPSS version 16. Elder group showed a significantly higher level of HSP-60, HSP-70, and HSP-90 than the control group. According to study results, the anti-oxidant profile, which includes SOD, CAT, and GSH, exhibited a dramatically declining trend in the aged population. MDA and NO, which are indicators of oxidative stress, were also higher in the elderly population than in the young. The study also showed that the elderly had lower vitamin A, C, D, and E levels than the young. The results reflect the increased level of inflammatory markers specifically heat shock proteins in old people compared to healthy control. It is indication that increased level of heat shock proteins are responsible for aging. It can be cured by limiting the heat shock proteins.

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Section: Discussionmentioning

confidence: 45%

Potential Role of Heat Shock Proteins 60, 70, and 90 in the Aging Among Population of Punjab-Pakistan

Riaz

NOREEN

Qaiser

et al. 2023

Biol Clin Sci Res J

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“…In addition, demographic parameters such as age, sex and osteoporosis can also affect the level of SOD and GR. For example, the levels of these two enzymes gradually decline with age and are higher in women than in men [ 43 , 44 ]. In addition, in the oxidative stress environment of osteoporosis, the antioxidant system and oxidation system are dysfunctional, and the level of antioxidant enzymes such as SOD is decreased [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

Serum antioxidant enzymes in spinal stenosis patients with lumbar disc herniation: correlation with degeneration severity and spinal fusion rate

Guo,

Zhou,

Zhao

et al. 2023

BMC Musculoskelet Disord

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Objective To determine whether superoxide dismutase (SOD) and glutathione reductase (GR) correlated with the intervertebral disc degeneration (IDD) severity and the postoperative spinal fusion rate in lumbar spinal stenosis patients accompanied with lumbar disc herniation. Methods This retrospective study investigated 310 cases of posterior lumbar decompression and fusion. The cumulative grade was calculated by adding the pfirrmann grades of all the lumbar discs. Subjects were grouped based on the median cumulative grade. Logistic regression was used to determine the associations among the demographical, clinical, and laboratory indexes and severe degeneration and fusion. The receiver operating characteristic (ROC) curve was performed to measure model discrimination, and Hosmer-Lemeshow (H-L) test was used to measure calibration. Results SOD and GR levels were significantly lower in the severe degeneration group (cumulative grade > 18) than in the mild to moderate degeneration group (cumulative grade ≤ 18). Furthermore, the SOD and GR concentrations of the fusion group were significantly higher than that of the non-fusion group (p < 0.001 and p = 0.006). The multivariate binary logistic models revealed that SOD and GR were independently influencing factors of the severe degeneration (OR: 0.966, 95%CI: 0.950–0.982, and OR: 0.946, 95%CI: 0.915–0.978, respectively) and non-fusion (OR: 0.962; 95% CI: 0.947–0.978; OR: 0.963; 95% CI: 0.933–0.994). The models showed excellent discrimination and calibration. Trend analysis indicated that the levels of SOD and GR tended to decrease with increasing severity (p for trend < 0.001 and 0.003). In addition, it also revealed that SOD provided protection from non-fusion in a concentration-dependent manner (p for trend < 0.001). However, GR concentration-dependent effects were not apparent (p for trend = 0.301). Conclusion High serum SOD and GR levels are associated with a better fusion prognosis and a relief in degeneration severity.

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“…Tissue integrity of antioxidants affects the development of diabetic complications as was reported by Dachana et al (2010). The enzymatic antioxidant, SOD, is one of the primary enzymes that directly eliminates reactive oxygen species (ROS), (Semenova et al, 2022). It is an important defense enzyme and a scavenger of O 2 from H 2 O 2 , the intervention diminishes the toxic effects due to free radical injury from secondary reaction (Abdel-Monsef et al, 2023).…”

Section: Superoxide Dismutase (Sod)mentioning

confidence: 96%

Ethanolic extract of Moringa oleifera leaves shows Anti-hyperglycemic potencies on experimental Wistar rats: a focus on optimization of biomarkers of type 2 diabetes

Ojimelukwe

2023

Preprint

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To improve the traditional use of Moringa oleifera for the management of type 2 diabetes, the potent plant parts (seeds, leaves, stem bark, roots) must be specified and the appropriate dosage should be quantified. This research reports quantitative findings on the antihyperglycaemic properties of M. oleifera leaves. Streptozotocin (STZ) induced type 2 diabetic Wistar rats, were treated with iterative levels of the ethanolic leaf extract of Moringa oleifera (X1). Time of exposure (X2) of the rats to the extract, concentration, and time of storage of the leaf sample before extraction (X3) were monitored. The biomarkers of type 2 diabetes in the rats were monitored in a response surface model to optimize the ideal conditions for the antihyperglycaemic effects of M oleifera leaves. Haemoglobin count increased from ≤11.25mmol/L) to 15.88 mmol/L) as the dose of the extract and time increased. Diabetic rats were glutathione deficient (70-98 mg/ml), which improved to 300mg/dL after treatment. Serum Superoxide dismutase (SOD) was 170 mm/moL in diabetic rats and 300 mmol/mL in fully treated rats. Blood glucose of STZ-induced diabetic rats (over 220mg/dL) decreased to normal levels of 70-90 mg/dl. The extract was safe at 2250 mg/kg body weight. Fifty (50) g of shade-dried ethanolic extract of M. oleifera leaves stored for less than 3 months restored STZ-induced diabetes in Wistar rats within 28 days.

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Superoxide Dismutase Activity in Male and Female Patients of Different Age with Moderate COVID-19

Cited by 20 publications

References 15 publications

Potential Role of Heat Shock Proteins 60, 70, and 90 in the Aging Among Population of Punjab-Pakistan

Potential Role of Heat Shock Proteins 60, 70, and 90 in the Aging Among Population of Punjab-Pakistan

Serum antioxidant enzymes in spinal stenosis patients with lumbar disc herniation: correlation with degeneration severity and spinal fusion rate

Ethanolic extract of Moringa oleifera leaves shows Anti-hyperglycemic potencies on experimental Wistar rats: a focus on optimization of biomarkers of type 2 diabetes

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