Superoxide anion radical scavenging activity of bilberry (Vaccinium myrtillus L.)

Tumbas, Vesna; Čanadanović-Brunet, Jasna; Gille, Lars; Đilas, Sonja M.; Ćetković, Gordana

doi:10.3233/br-2010-002

Cited by 24 publications

(15 citation statements)

References 49 publications

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“…The scavenging ability of sweet cherry fruits against O2-radical was already demonstrated by Prior et al [23]. In respect to other red fruits, our total extract exhibited similar activity to vitamin C rich fraction of bilberry fruits (Vaccinium myrtillus L.) (IC50 = 49 μg/ml), but less efficiency than their flavonoid (IC50 = 21 μg/ml) and phenolic acid (IC50 = 15 μg/ml) rich fractions [24]. Moreover, our total extract and non-coloured fraction proved to have higher ability to scavenge these species when compared with ethanolic extracts of strawberry fruits (IC50 = 72.5 μg/ml), but less activity than those of acetone (IC50 = 9.7 μg/ml).…”

Section: Antioxidant Activitysupporting

confidence: 72%

Antioxidant Status, Antidiabetic Properties and Effects on Caco-2 Cells of Coloured and Non-Coloured Enriched Extracts of Sweet Cherry Fruits

Gonçalves¹,

Rodrigues²,

Santos³

et al. 2018

Preprint

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This study aimed to compare three different extracts of Saco sweet cherry, namely non-coloured fraction, coloured fraction and total extract concerning phenolic composition, antioxidant and antidiabetic potential, erythrocytes’ protection and effects on Caco-2 cells. A total of 22 phenolic compounds were identified by LC-DAD. Hydroxycinnamic acids were the most predominant in both non-coloured fraction and total extract, while cyanidin-3-O-rutinoside was the main anthocyanin found in the coloured fraction. The total extract was the most effective against DPPH, nitric oxide and superoxide radicals, and in the inhibition of α-glucosidase enzyme. Finally, the protective effect of the extracts to prevent oxidative damage in human erythrocytes was assessed. The coloured fraction revealed the best activity against hemoglobin oxidation and hemolysis. Regarding to Caco-2 cells, the coloured extract exhibited the most cytotoxic effects, while the total extract was the most efficient in protecting these cells against oxidative damage induced by t-BHP.

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Section: Antioxidant Activitysupporting

confidence: 72%

Antioxidant Status, Antidiabetic Properties and Effects on Caco-2 Cells of Coloured and Non-Coloured Enriched Extracts of Sweet Cherry Fruits

Gonçalves¹,

Rodrigues²,

Santos³

et al. 2018

Preprint

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show abstract

“…The scavenging ability of sweet cherry fruits against O 2 •− was already demonstrated by Prior et al [ 23 ]. With respect to other red fruits, our total extract exhibited similar activity to the vitamin C rich fraction of bilberry fruits ( Vaccinium myrtillus L.) (IC 50 = 49 µg/mL), but less efficiency than their flavonoid (IC 50 = 21 µg/mL) and phenolic acid (IC 50 = 15 µg/mL) rich fractions [ 24 ]. Moreover, our total extract and non-colored fraction proved to have higher ability to scavenge these species when compared with ethanolic extracts of strawberry fruits (IC 50 = 72.5 µg/mL), but less activity than those of acetone (IC 50 = 9.7 µg/mL).…”

Section: Resultsmentioning

confidence: 99%

Antioxidant Status, Antidiabetic Properties and Effects on Caco-2 Cells of Colored and Non-Colored Enriched Extracts of Sweet Cherry Fruits

et al. 2018

View full text Add to dashboard Cite

This study aimed to compare three different extracts of Saco sweet cherry, namely the non-colored fraction, colored fraction, and total extract concerning phenolic composition, antioxidant and antidiabetic potential, and erythrocytes’ protection and effects on Caco-2 cells. Twenty-two phenolic compounds were identified using high-performance liquid chromatography with diode-array detection. Hydroxycinnamic acids were the most predominant in both the non-colored fraction and total extract, while cyanidin-3-O-rutinoside was the main anthocyanin found in the colored fraction. The total extract was the most effective against 1,1-diphenyl-2-picrylhydrazyl, nitric oxide, and superoxide radicals, and in the inhibition of α-glucosidase enzyme. The colored fraction revealed the best activity against hemoglobin oxidation and hemolysis. Regarding to Caco-2 cells, the colored extract exhibited the highest cytotoxic effects, while the total extract was the most efficient in protecting these cells against oxidative damage induced by tert-butyl hydroperoxide.

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“…Free radical scavenging activity on superoxide anion radicals was measured according to Tumbas et al. (2010).…”

Section: Methodsmentioning

confidence: 99%

In vitro antioxidant and antiproliferative activity of three rosemary (Rosmarinus officinalis L.) extract formulations

Đilas

Knez

Četojević-Simin

et al. 2012

Int J of Food Sci Tech

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Summary Antioxidant and antiproliferative activities of three rosemary extract formulations (VivOX 20, VivOX 40 and Inolens 50) with different contents of carnosic acid, carnosol and methylcarnosol were tested in vitro. Electron spin resonance measurements revealed that Inolens 50 extract that contained highest amount of carnosic acid was the most potent scavenger of hydroxyl (concentration of extract where 50% of its maximal scavenging activity is observed, that is, EC50, 109.54 μg mL−1), superoxide anion (EC50 = 7.94 μg mL−1) and 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) (EC50 = 27.4 μg mL−1)‐free radicals. Comparison of the radar charts of standard antioxidants and rosemary extracts showed similarity between antioxidant characteristics of Inolens 50 and chlorogenic and caffeic acids. Tested rosemary extracts exhibited significant (P ≤ 0.01) antiproliferative effect in cervix epitheloid carcinoma (HeLa), breast adenocarcinoma (MCF7) and colon adenocarcinoma (HT‐29) cell lines. In both MCF7 and HeLa cell lines, the extracts yielded very low IC50 values (concentration of extract needed to inhibit cell growth by 50%), the most pronounced being for Inolens 50 in MCF7 (IC50 = 9.95 μg mL−1) and VivOX 20 in HeLa cell line (IC50 = 10.02 μg mL−1). The obtained results may provide support for the use of tested rosemary extracts as nutraceuticals and phytopharmaceuticals.

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Superoxide anion radical scavenging activity of bilberry (Vaccinium myrtillus L.)

Cited by 24 publications

References 49 publications

Antioxidant Status, Antidiabetic Properties and Effects on Caco-2 Cells of Coloured and Non-Coloured Enriched Extracts of Sweet Cherry Fruits

Antioxidant Status, Antidiabetic Properties and Effects on Caco-2 Cells of Coloured and Non-Coloured Enriched Extracts of Sweet Cherry Fruits

Antioxidant Status, Antidiabetic Properties and Effects on Caco-2 Cells of Colored and Non-Colored Enriched Extracts of Sweet Cherry Fruits

In vitro antioxidant and antiproliferative activity of three rosemary (Rosmarinus officinalis L.) extract formulations

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