Superiority of amino-modified chiral mesoporous silica nanoparticles in delivering indometacin

Abstract

The present study established indometacin (IMC) delivery system with chiral mesoporous silica nanoparticles (CMSNs) and amino-modified chiral mesoporous silica nanoparticles (Amino-CMSNs) that previously reported as pharmaceutical excipients, and their systemic biological effects, mainly consisting of in vitro drug intestinal permeability, haemolysis assay, in vivo pharmacokinetics, anti-inflammation pharmacodynamics and gastric irritation, were addressed. It turned out that the two IMC delivery systems established by CMSN and Amino-CMSN significantly improved drug intestinal permeability due to the improved drug dissolution caused by conversion of drug crystalline state to amorphous phase. Further, IMC-loaded Amino-CMSN was the superior choice because of its higher dissolution rate. Furthermore, CMSN and Amino-CMSN were safe to be circulated in blood, and Amino-CMSN with significant lower haemolysis ratio than CMSN was better for the minimum haemolytic behaviour. Oral bioavailability and anti-inflammation effect of IMC delivery systems established by CMSN and Amino-CMSN were enhanced compared with IMC, which was attributed to the primary cause of the improvement of IMC dissolution, and Amino-CMSN exhibited better biological effect. As a result of these facts, it is believed that the effective delivery of IMC by Amino-CMSN will provide a new candidate to formulate poorly soluble drugs so as to significantly develop pharmaceutical application.

Effect of Shape on Mesoporous Silica Nanoparticles for Oral Delivery of Indomethacin

“…Pahweenvaj Ratnatilaka Na Bhuket designed a prodrug for curcumin to improve its solubility and oral bioavailability [16]. Li et al found that amino-modified chiral mesoporous silica nanoparticles exhibited improved drug dissolution and reduced hemolysis, which subsequently increased bioavailability [17]. It is therefore of great importance to develop various approaches to improve the water-solubility of BCS II drugs.…”

Effects of Different Surface Functionalizations of Silica Nanoparticles on Mesenchymal Stem Cells

“…Other than these two factors, we also could not dismiss the effects of other physicochemical properties of nanoparticles such as particle shape 23,24 and stiffness. 25 The use of aminofunctionalized silica nanoparticles as drug nanocarriers offers some advantages such as neglectable cytotoxicity, 10 safe for circulation in blood, 26 higher dissolution rate and bioavailability, 26 and improved thermal stability. 27 To study how functionalized silica nanoparticles internalized into cells, we also treated cells with endocytosis inhibitors such as Amiloride-HCl or Amantadine-HCl.…”

Recent advances in glucose-oxidase-based nanocomposites for diabetes diagnosis and treatment

“…These porous materials This journal is © The Royal Society of Chemistry 2023 are widely used in biosensors and drug delivery systems because of their large pore size, high surface area, tunable pore shape, flexible modification of the inner and outer surfaces, and relatively good thermal stability. [38][39][40][41][42][43] The large specific surface area and pore volume of MSNs can provide space for the adsorption or storage of biomolecules such as GOx. In addition, the inner and outer surfaces of MSNs can be modified with simple groups to enable complex functionalization of the material.…”