Superior sulcus non-small cell lung carcinoma: A comparison of IMRT and 3D-RT dosimetry

Abstract

Background: IMRT became the main technique in modern radiotherapy. However it was not

An in-silico quality assurance study of contouring target volumes in thoracic tumors within a cooperative group setting

“…Despite efforts to provide guidelines for more reproducible target delineation across different institutes [14] , [16] , [41] , inter-observer variations are still a barrier that faces multi-institutional trials [2] . Another barrier is the absence of an optimized protocol to account for different imaging modalities when it comes to RT planning for Pancoast tumors [22] . Consequently, our group sought to quantitatively determine the inter-observer variability of expert radiotherapy target-volume delineation for Pancoast tumors, towards developing an expert-consensus contouring atlas.…”

“…The study was designed in a multi-user fashion combining objective evaluation of specific target delineation and dose parameters with user reported data. Pancoast tumors were selected as test cases for this concept study; given the relatively strong agreement on target and OARs delineation among radiation oncologists [22] , [23] . Radiotherapy guidelines were drafted and multimodality simulation images were acquired as a part of a then-existing SWOG Pancoast tumor clinical trial protocol.…”

Zaštita Od Zračenja Pacijenata U Toku Radioterapijskog Tretmana Primjenom Modernih Tehnika Zračenja

“…Obrađena su 652 pacijenta, i to 206 pacijenata tretiranih 3DCRT i 446 pacijenata tretiranih IMRT, a rezultati su pokazali da IMRT pluća u odnosu na 3DCRT omogućava signifikantno bolju lokoregionalnu kontrolu bolesti i reducira toksicitet na pluća, dok nije bilo signifikantne razlike u ukupnom preživljenju i toksicitetu na ezofagus za stadij III NSCLC [14]. I druga istraživanja potvrđuju prednost IMRT u odnosu na 3DCRT, kako u smislu isporuke veće doze na ciljni volumen tako i poštede zdravih tkiva [15][16][17]. Iradijacija pleure zbog malignog mezotelioma ranije je značila istovremenu isporuku visokih doza i na zdravi parenhim pluća.…”

Respiratory motion and its compensation possibilities in the modern external beam radiotherapy of lung cancer

“…However, a single three-dimensional reconstruction of tomographic images is usually done before the course of radiotherapy. Therefore, during the whole external beam radiation therapy treatment, it is necessary to: -use dedicated anatomical fixation accessories; -use filling procedures dedicated for the organs within the irradiated area; -compensate anatomical changes by applying appropriate therapeutic margins to define irradiated volumes; -perform pre-fraction verification procedures to check the patient's geometry before each daily irradiation as well as inspect the patient's position during external beam treatment (intra-fraction verification) [2][3][4][5][6].…”