Superior mesenteric artery occlusion and peripheral emboli caused by an aortic ulcer in a young patient with antiphospholipid syndrome

Vahl, A.C.; Gans, Rijk O. B.; Mackaay, A. J. C.; Waal, C. van der; Rauwerda, J. A.

doi:10.1016/s0039-6060(97)90116-1

Cited by 12 publications

(3 citation statements)

References 3 publications

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“…Gastric ulceration with necrosis due to widespread occlusive vascular disease88 as well as small and large bowel vascular occlusions in aPL-positive patients were also reported 89,90. Gastrointestinal haemorrhage as a result of bowel ischaemia or an atypical duodenal ulcer91 occurs most frequently in CAPS patients (abdominal pain is one of the most common manifestations in such cases).…”

Section: Aps and Vaso-ischemic (Occlusive) Diseases With Neuropsychiamentioning

confidence: 99%

Antiphospholipid Syndrome and Vascular Ischemic (Occlusive) Diseases: An Overview

Atanassova

2007

Yonsei Med J

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Antiphospholipid syndrome (APS) is primarily considered to be an autoimmune pathological condition that is also referred to as "Hughes syndrome". It is characterized by arterial and/or venous thrombosis and pregnancy pathologies in the presence of anticardiolipin antibodies and/or lupus anticoagulant. APS can occur either as a primary disease or secondary to a connective tissue disorder, most frequently systemic lupus erythematosus (SLE). Damage to the nervous system is one of the most prominent clinical constellations of sequelae in APS and includes (i) arterial/venous thrombotic events, (ii) psychiatric features and (iii) other non-thrombotic neurological syndromes. In this overview we compare the most important vascular ischemic (occlusive) disturbances (VIOD) with neuro-psychiatric symptomatics, together with complete, updated classifications and hypotheses for the etio-pathogenesis of APS with underlying clinical and laboratory criteria for optimal diagnosis and disease management.

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Section: Aps and Vaso-ischemic (Occlusive) Diseases With Neuropsychiamentioning

confidence: 99%

Antiphospholipid Syndrome and Vascular Ischemic (Occlusive) Diseases: An Overview

Atanassova

2007

Yonsei Med J

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“…Several cases of large-bowel and intestinal infarctions in patients with aPL have been reported (178)(179)(180)(181)(182)(183)(184). Peritonitis is not a rare accompaniment.…”

Section: Small-and Large-bowel Vascular Occlusionsmentioning

confidence: 99%

Unusual Manifestations of the Antiphospholipid Syndrome

Asherson

Cervera

2003

CRIAI

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The classical clinical picture of the antiphospholipid syndrome (APS) is characterized by venous and arterial thromboses, fetal losses and thrombocytopenia, in the presence of antiphospholipid antibodies (aPL), namely lupus anticoagulant (LA), anticardiolipin antibodies (aCL), or antibodies to the protein "cofactor" b2 glycoprotein I. Single vessel involvement or multiple vascular occlusions may give rise to a wide variety of presentations. Any combination of vascular occlusive events may occur in the same individual and the time interval between them also varies considerably from weeks to months or even years. Deep vein thrombosis, sometimes accompanied by pulmonary embolism, is the most frequently reported manifestation in this syndrome. Cerebrovascular accidents-either stroke or transient ischemic attacks-are the most common arterial thrombotic manifestations. Early and late fetal losses, premature births and pre-eclampsia are the most frequent fetal and obstetric manifestations. Additionally, several other clinical features are relatively common in these patients, i.e., thrombocytopenia, livedo reticularis, heart valve lesions, hemolytic anemia, epilepsy, myocardial infarction, leg ulcers, and amaurosis fugax. However, a large variety of other clinical manifestations have been less frequently described in patients with the APS, with prevalences lower than 5%. These include, among others, large peripheral or aortic artery occlusions, Sneddon's syndrome, chorea, transverse myelopathy, intracardiac thrombus, adult respiratory distress syndrome, renal thrombotic microangiopathy, Addison's syndrome, Budd-Chiari syndrome, nodular regenerative hyperplasia of the liver, avascular necrosis of the bone, cutaneous necrosis or subungual splinter hemorrhages. In this article, some of these "unusual" manifestations are reviewed.

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“…APA can be observed in thrombotic events of the cerebral, axillary, renal and hepatic (Budd-Chiari syndrome) veins, as well as in arterial thromboses [39, 64,81]. Moreover, different clinical features such as pulmonary hypertension [5], heart valve disease [31], labile hypertension, recurrent abortion and thrombocytopenia are associated with APA [47,66].…”

Section: Introductionmentioning

confidence: 99%