Superior ECD Performance through Design and Application

Klee, Matthew S.; Williams, M. D.; Chang, Imogene; Murphy, Joseph

doi:10.1002/(sici)1521-4168(19990101)22:1<24::aid-jhrc24>3.0.co;2-n

Cited by 24 publications

(3 citation statements)

References 2 publications

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“…Gases used for GC–ECD must be ultrapure to protect both the GC column (which can be oxidized by trace oxygen or siloxanes hydrolyzed by trace water) and the ECD itself. Recent refinements in ECD technology include the use of microcells which have greater linear range than older detector cells [108] and can provide greater sensitivity. …”

Section: Quantification Methodsmentioning

confidence: 99%

Analytical methods for PCBs and organochlorine pesticides in environmental monitoring and surveillance: a critical appraisal

2006

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Analytical methods for the analysis of polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) are widely available and are the result of a vast amount of environmental analytical method development and research on persistent organic pollutants (POPs) over the past 30-40 years. This review summarizes procedures and examines new approaches for extraction, isolation, identification and quantification of individual congeners/ isomers of the PCBs and OCPs. Critical to the successful application of this methodology is the collection, preparation, and storage of samples, as well as specific quality control and reporting criteria, and therefore these are also discussed. With

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Section: Quantification Methodsmentioning

confidence: 99%

Analytical methods for PCBs and organochlorine pesticides in environmental monitoring and surveillance: a critical appraisal

2006

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“…The recent development has been in the miniaturization of these devices. Klee et al described the development of a μECD with cell volume of 1/10 of the original design with improved sensitivity, larger dynamic range, and much smaller cell volume. These commercialized μECDs have been used in the analysis of a wide range of samples (reviewed in ref ).…”

Section: Detectorsmentioning

confidence: 99%

Micro Gas Chromatography: An Overview of Critical Components and Their Integration

2018

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Among a number of gas analyzers, portable gas chromatography (GC) systems created by the integration of microfabricated components are promising candidates for rapid and on-site analysis of a number of complex chemical mixtures. This Feature provides a snapshot of the progress made in developing micro gas chromatography (μGC) systems in the last 4 decades. In particular, we discuss the development of microfabricated preconcentrators, separation columns, and detectors. Furthermore, we review different stationary phase materials used to coat the separation columns and the major efforts toward the development of an integrated μGC.

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“…The modulation period varied between 5 and 8 s, depending on the experiment. A high detector temperature (300°C) and the highest possible makeup gas flow (150 mL/min) and data collection (50 Hz) rates were used to avoid unnecessary extra-column band broadening [15,30]. However, it should be noted that there is a compromise between resolution (band width) and sensitivity.…”

Section: Samples and Experimental Designmentioning

confidence: 99%

GC×GC-ECD: a promising method for the determination of dioxins and dioxin-like PCBs in food and feed

Haglund

Korytár²,

Danielsson

et al. 2008

Anal Bioanal Chem

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There is a need for cost-efficient alternatives to gas chromatography (GC)-high-resolution mass spectrometry (HRMS) for the analysis of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (PCBs) in food and feed. Comprehensive two-dimensional GC-micro electron capture detection (GC× GC-μECD) was tested and all relevant (according to the World Health Organisation, WHO) PCDD/Fs and PCBs could be separated when using a DB-XLB/LC-50 column combination. Validation tests by two laboratories showed that detectability, repeatability, reproducibility and accuracy of GC×GC-μECD are all statistically consistent with GC-HRMS results. A limit of detection of 0.5 pg WHO PCDD/ F tetrachlorodibenzo-p-dioxin equivalency concentration per gram of fish oil was established. The reproducibility was less than 10%, which is below the recommended EU value for reference methods (less than 15%). Injections of vegetable oil extracts spiked with PCBs, polychlorinated naphthalenes and diphenyl ethers at concentrations of 200 ng/g showed no significant impact on the dioxin results, confirming in that way the robustness of the method. The use of GC×GC-μECD as a routine method for food and feed analysis is therefore recommended. However, the data evaluation of low dioxin concentrations is still laborious owing to the need for manual integration. This makes the overall analysis costs higher than those of GC-HRMS. Further developments of software are needed (and expected) to reduce the data evaluation time. Combination of the current method with pressurised liquid extraction with in-cell cleanup will result in further reduction of analysis costs.

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Superior ECD Performance through Design and Application

Cited by 24 publications

References 2 publications

Analytical methods for PCBs and organochlorine pesticides in environmental monitoring and surveillance: a critical appraisal

Analytical methods for PCBs and organochlorine pesticides in environmental monitoring and surveillance: a critical appraisal

Micro Gas Chromatography: An Overview of Critical Components and Their Integration

GC×GC-ECD: a promising method for the determination of dioxins and dioxin-like PCBs in food and feed

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