Superior and distinct antioxidant effects of selected estrogen metabolites on lipid peroxidation

Tang, Maoyun; Abplanalp, William; Ayres, Stacey A.; Subbiah, M.T.R.

doi:10.1016/s0026-0495(96)90212-7

Cited by 82 publications

(39 citation statements)

References 15 publications

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“…32,33 However, in our data, oestradiol has no effect on the lipid peroxidation for some unknown reason. The normal physiological level of oestrogen is 0.5 ng/ml.…”

Section: Eyecontrasting

confidence: 62%

Rapid action of oestradiol against hydrogen peroxide-induced oxidative stress in cataractous lens epithelium: an in vitro study

Gajjar¹,

Patel²,

Alapure³

et al. 2008

Eye

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Purpose To evaluate the short-term protective effects of oestradiol against damages because of oxidative stress in human lens epithelial cells (LECs). Methods The central zone of human lens epithelium was obtained from the cataract surgery and cultured in MEM culture medium. These cultured LECs were treated with 17b-oestradiol for varying time intervals from 1 to 5 min followed by treatment with H 2 O 2 (5 Â 10 À6 M) in the culture medium. Catalase activity was measured to access the oxidative stress levels. Results LECs exposed to H 2 O 2 (5 Â 10 À6 M) showed a fourfold increase in catalase activity (407.03±89.11 U/lg protein) after 6 h when compared to cultured unexposed LECs (97.124±9.4 U/lg protein). When the cultured LECs were treated with oestradiol (5 Â 10 À8 M) before H 2 O 2 treatment, the increase in catalase activity was inhibited, whereas simultaneous and post-treatments showed no effect. The catalase activity of LECs pretreated with oestradiol for 1, 2, 3 ,and 5 min was 259. 92±18.37, 200.24±14.39, 140.50±19.83, and 110.01±14.66, respectively (Po0.0001). Conclusion Antioxidative enzymes are synthesized in response to the oxidative stress signal. Upon treatment with oestrogen catalase is not synthesized. The pretreatment time of oestrogen required for its antioxidative effect can be seen within 5 min indicating non-genomic mode of action of oestrogen.

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“…32,33 However, in our data, oestradiol has no effect on the lipid peroxidation for some unknown reason. The normal physiological level of oestrogen is 0.5 ng/ml.…”

Section: Eyecontrasting

confidence: 62%

Rapid action of oestradiol against hydrogen peroxide-induced oxidative stress in cataractous lens epithelium: an in vitro study

Gajjar¹,

Patel²,

Alapure³

et al. 2008

Eye

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“…Numerous studies of ischemic and TBI have provided a large bulk of evidence supporting the neuroprotective effect of estrogens. Although various hypotheses have been proposed to explain the neuroprotective effect of estrogens in brain injury such as augmentation of cerebral blood flow 59 usually linked to the increase of nitric oxide availability, 60 anti-oxidant activity, 61 and reduction of excitotoxic effects mediated by glutamate release, 62 accumulating evidence links estrogens to the bcl-2 family of proteins. In ischemic brain injury, bcl-2 mRNA expression has been found to be higher in the penumbra area in female and estradiol-treated male rats than in estrogen deficient animals.…”

Section: Modulators Of Mitochondrial Membrane Permeabilizationmentioning

confidence: 99%

Mitochondrial Damage: A Target for New Therapeutic Horizons

Soustiel

Larisch

2010

Neurotherapeutics

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Summary: Traumatic brain injury (TBI) represents a leading cause of death and morbidity, as well as a considerable social and economical burden in western countries, and has thus emerged as a formidable therapeutic challenge. Yet despite tremendous efforts enlightening the mechanisms of neuronal death, hopes for the "magic bullet" have been repeatedly deceived, and TBI management has remained focused on the control of increased intracranial pressure. Indeed, impairment of cerebral metabolism is traditionally attributed to impaired oxygen delivery mediated by reduced cerebral perfusion in the swollen cerebral parenchyma. Although intuitively appealing, this hypothesis is not entirely supported by physiological facts and does not take into consideration mitochondrial dysfunction that has been repeatedly reported in both human and animal TBI. Although the nature and origin of the events leading to mitochondrial damage may be different, most share a permeabilization of mitochondrial membrane, which therefore may represent a logical target for new therapeutic strategies. Therefore, the proteins mediating these events may represent promising targets for new TBI therapies. Furthermore, mimicking anti-apoptotic proteins, such as Bcl-2 or XIAP, or inhibiting mitochondrial pro-apoptotic proteins, such as Smac/DIABLO, Omi/HTRA2, and ARTS (septin 4 isoform 2) may represent useful novel therapeutic strategies. This review focuses on mechanisms of the mitochondrial membrane permeabilization and its consequences and discusses the current and possible future therapeutic implications of this key event of neuronal death.

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“…The combined extracts were washed with brine and dried. Solvent removal, chromatography (20% EtOAc in hexanes) and recrystallization from acetone/hexanes gave product 17a (30 70 (s, 3H, C 18 -CH 3 ), 2.77-2.78 (m, 2H, C 6 -CH 2 ), 3.75 (q, J = 6 Hz, 1H, C 17 -H), 6.54 (d, 1H, J = 2.4 Hz, C 4 -H), 6.59 (dd, 1H, J = 8.4 Hz, 2.4 Hz, C 2 -H), 7.10 (d, 1H, J = 8.4 Hz, C 1 -H); 13 24. (8α,13α,14β,17β)-Estra-1,3,5(10),9(11)-tetraene-3,17-diol (17b)-A solution of compound 16b (60 mg, 0.21 mmol) in anhydrous toluene (3 ml) under N 2 was added to DIBALH (1.5 M in toluene, 1.5 ml, 2.25 mmol).…”

Section: (1r7ar)-1-(11-dimethylethoxy)-123677a-hexhydro-4-[2-(mentioning

confidence: 99%

“…Estrone and 17 -estradiol, as well as other steroids containing a phenolic A-ring, are antioxidants with neuroprotective properties that are potentially useful for the treatment of Alzheimer's disease, Parkinson's disease and other neurodegenerative diseases [1][2][3][4][5][6]. Since the antioxidant properties of 17 -estradiol are not dependent on the absolute configuration of this steroid, ent-17 -estradiol also has neuroprotective properties [7].…”

Section: Introductionmentioning

confidence: 99%

A facile total synthesis of ent-17β-estradiol and structurally related analogues

Cai

Covey

2007

Steroids

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Superior and distinct antioxidant effects of selected estrogen metabolites on lipid peroxidation

Cited by 82 publications

References 15 publications

Rapid action of oestradiol against hydrogen peroxide-induced oxidative stress in cataractous lens epithelium: an in vitro study

Rapid action of oestradiol against hydrogen peroxide-induced oxidative stress in cataractous lens epithelium: an in vitro study

Mitochondrial Damage: A Target for New Therapeutic Horizons

A facile total synthesis of ent-17β-estradiol and structurally related analogues

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