Multi-parametric families of AdS 4 vacua with various amounts of supersymmetry and residual gauge symmetry are found in the [SO(1, 1) × SO(6)] ⋉ R 12 maximal supergravity that arises from the reduction of type IIB supergravity on R × S 5 . These provide natural candidates to holographically describe new strongly coupled three-dimensional CFT's which are localised on interfaces of N = 4 super-Yang-Mills theory. One such AdS 4 vacua features a symmetry enhancement to SU(2) × U(1) while preserving N = 2 supersymmetry. Fetching techniques from the E 7(7) exceptional field theory, its uplift to a class of N = 2 S-folds of type IIB supergravity of the form AdS 4 × S 1 × S 5 involving S-duality twists of hyperbolic type along S 1 is presented.