Superfluorinated and NIR-luminescent gold nanoclusters

Dichiarante, Valentina; Tirotta, Ilaria; Catalano, Luca; Terraneo, Giancarlo; Raffaini, Giuseppina; Chierotti, Michele R.; Gobetto, Roberto; Bombelli, Francesca Baldelli; Metrangolo, Pierangelo

doi:10.1039/c6cc09324h

Cited by 21 publications

(35 citation statements)

References 29 publications

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“…The aggregation-induced luminescence of NCs has been achieved either using solvent-induced aggregation or addition of additives such as ionic polymers, proteins or peptides [74][75][76]. Recently, Dichiarante et al reported NIR-luminescent AuNCs bearing superfluorinated (SF) ligands with strong emission at 1050 nm with a quantum yield of 12% [77]. An extensive account of the PL of NCs is beyond the scope of this review and has been previously summarized in several reports [54,[78][79][80][81][82].…”

Section: Review Luminescent Gold Nanoclustersmentioning

confidence: 99%

Luminescent gold nanoclusters for bioimaging applications

Nonappa¹

2020

Beilstein J. Nanotechnol.

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Luminescent nanomaterials have emerged as attractive candidates for sensing, catalysis and bioimaging applications in recent years. For practical use in bioimaging, nanomaterials with high photoluminescence, quantum yield, photostability and large Stokes shifts are needed. While offering high photoluminescence and quantum yield, semiconductor quantum dots suffer from toxicity and are susceptible to oxidation. In this context, atomically precise gold nanoclusters protected by thiol monolayers have emerged as a new class of luminescent nanomaterials. Low toxicity, bioavailability, photostability as well as tunable size, composition, and optoelectronic properties make them suitable for bioimaging and biosensing applications. In this review, an overview of the sensing of pathogens, and of in vitro and in vivo bioimaging using luminescent gold nanoclusters along with the limitations with selected examples are discussed.

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Section: Review Luminescent Gold Nanoclustersmentioning

confidence: 99%

Luminescent gold nanoclusters for bioimaging applications

Nonappa¹

2020

Beilstein J. Nanotechnol.

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“…This can be achieved by PEGylation, [76] encapsulation with hydrophilic polymer [77] or micellization [78] . Labelling of the particles with small amount of fluorescent ligands [76] may be necessary: several types of nanoparticles possess inherent fluorescent properties which simplifies the design of dual 19 F/OFI probes [77,79] . This is especially true for smaller Au‐cores (1–2 nm diameter or less) which emit in the NIR region [79] and provide excellent alternatives to organic NIR emitters.…”

Section: Dual 19f Mri/ofi Probesmentioning

confidence: 99%

“…Nevertheless, the polydispersity of the Au‐core resulted in a small splitting of the main sharp 19 F NMR resonance at −71.14 ppm. Another significant issue with the probe was its poor solubility in aqueous environment, which may be a limiting factor in potential diagnostic applications [79] …”

Section: Dual 19f Mri/ofi Probesmentioning

confidence: 99%

¹⁹F MRI Probes for Multimodal Imaging**

Janasik

Krawczyk

2021

Chemistry A European J

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Magnetic resonance imaging (MRI) is one of the most powerful imaging tools today, capable of displaying superior soft‐tissue contrast. This review discusses developments in the field of 19F MRI multimodal probes in combination with optical fluorescence imaging (OFI), 1H MRI, chemical exchange saturation transfer (CEST) MRI, ultrasonography (USG), X‐ray computed tomography (CT), single photon emission tomography (SPECT), positron emission tomography (PET), and photoacoustic imaging (PAI). In each case, multimodal 19F MRI probes compensate for the deficiency of individual techniques and offer improved sensitivity or accuracy of detection over unimodal counterparts. Strategies for designing 19F MRI multimodal probes are described with respect to their structure, physicochemical properties, biocompatibility, and the quality of images.

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“…Atomic nanoclusters with large Stokes shifted emission, size tunable luminescence, good biocompatibility, high photostability and regular structure, are ideal candidates for biological imaging and chemical sensing . Among the multitude of nanoclusters, the case of thiol‐protected nanoclusters is especially intriguing owing to their stability due to the attainment of “magic number” .…”

Section: Introductionmentioning

confidence: 99%

Zinc‐Ion‐Induced Aggregation of Gold Clusters for Visible‐Light‐Excitation‐Based Fluorimetric Discrimination of Geometrical Isomers

2020

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Herein, we report discrimination of dicarboxylic acids -fumaric acid (FA) and maleic acid (MA) -exhibiting geometrical isomerism, using nanoclusters based luminescent probe having excitation under broad day light. The luminescent probe was designed via complexation reaction between zinc ions and ligands (mercaptopropioinc acid; MPA) stabilizing the gold nanoclusters. This resulted in formation of nanoaggregates exhibiting bright green luminescence upon excitation at 450 nm capable of discriminating between FA and MA upto nanomolar level. The basis of discrimination has been attributed to deprotonation of FA and MA following interaction with MPA moieties present on the surface of the nanoaggregates and being governed by the stability of the respective conjugate base of the geometrical isomers of the dicarboxylic acids. As a consequence of different extent of deprotonation of FA and MA upon interaction with the cluster aggregates, different effect on the luminescence of the aggregates was observed, thus enabling discernible fluorimetric discrimination between FA and MA under visible light excitation.[a] Dr.

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Superfluorinated and NIR-luminescent gold nanoclusters

Cited by 21 publications

References 29 publications

Luminescent gold nanoclusters for bioimaging applications

Luminescent gold nanoclusters for bioimaging applications

¹⁹F MRI Probes for Multimodal Imaging**

Zinc‐Ion‐Induced Aggregation of Gold Clusters for Visible‐Light‐Excitation‐Based Fluorimetric Discrimination of Geometrical Isomers

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Superfluorinated and NIR-luminescent gold nanoclusters

Cited by 21 publications

References 29 publications

Luminescent gold nanoclusters for bioimaging applications

Luminescent gold nanoclusters for bioimaging applications

19F MRI Probes for Multimodal Imaging**

Zinc‐Ion‐Induced Aggregation of Gold Clusters for Visible‐Light‐Excitation‐Based Fluorimetric Discrimination of Geometrical Isomers

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Product

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¹⁹F MRI Probes for Multimodal Imaging**