Superficially located enlarged lymphoid follicles characterise nodular gastritis

Host response genes associated with nodular gastritis in Helicobacter pylori infection

“…CXCL13 expressed by follicular dendritic cells and marginal reticular cells attracts circulating naïve B cells to lymphoid follicles and contributes to the initiation of GC formation . Significant overexpression of CXCL13 on the pediatric and adult antral mucosa in this study suggests the existence of lymphoid follicles in the H. pylori ‐infected mucosa regardless of NG appearance, and supports the histological finding of a similar number of lymphoid follicles in NG and AG …”

“…Shiotani et al . and Okamura et al . reported that the histologic differences between the NG mucosa and the AG mucosa were the size and location of lymphoid follicles.…”

“…It may be that gastric nodularity is the normal manifestation of the host immune response to chronic infection of gastric mucosa in children. It is generally thought that lymphoid follicles with germinal centers (GC) create the nodules on the gastric mucosa, and histological findings of NG include lymphoid hyperplasia . Therefore, NG appears to be gastric nodularity induced as a result of chronic inflammation and lymphoid hyperplasia caused by chronic bacterial infection, which is manifested predominantly in the antrum.…”

“…It is generally thought that lymphoid follicles with germinal centers (GC) create the nodules on the gastric mucosa, and histological findings of NG include lymphoid hyperplasia. 7,9,17,30,31 Therefore, NG appears to be gastric nodularity induced as a result of chronic inflammation and lymphoid hyperplasia caused by chronic bacterial infection, which is manifested predominantly in the antrum. Many factors including patient age and gender, duration of infection, species of pathogen, density of pathogen and grade of gastritis are related to the development of NG.…”

“…[5][6][7][8][9][10][11][12][13][14][15][16][17] The underlying mechanisms of development of NG, preferentially in children, have not been elucidated. Shiotani et al and Okamura et al 12,31 reported that the histologic differences between the NG mucosa and the AG mucosa were the size and location of lymphoid follicles. The lymphoid follicles in NG tissue were observed to be larger and more superficially located compared with AG tissue.…”