Superficial Characteristics of Titanium after Treatment of Chorreated Surface, Passive Acid, and Decontamination with Argon Plasma

Rizo-Gorrita, María; Luna-Oliva, Irene; Serrera-Figallo, María-Ángeles; Torrés-Lagares, Daniel

doi:10.3390/jfb9040071

Cited by 8 publications

(10 citation statements)

References 48 publications

(77 reference statements)

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“…Because of its decontaminating properties, argon plasma (Ar), which is widely used as a coagulant in digestive surgery [ 73 ], has been proposed by certain authors [ 52 , 74 , 75 , 76 , 77 ] to improve early integration of Ti implants due to its decontaminating properties.…”

Section: Discussionmentioning

confidence: 99%

Bioactive Surfaces vs. Conventional Surfaces in Titanium Dental Implants: A Comparative Systematic Review

López-Valverde

Flores-Fraile

Ramı́rez

et al. 2020

JCM

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Animal studies and the scarce clinical trials available that have been conducted suggest that bioactive surfaces on dental implants could improve the osseointegration of such implants. The purpose of this systematic review was to compare the effectiveness of osseointegration of titanium (Ti) dental implants using bioactive surfaces with that of Ti implants using conventional surfaces such as sandblasted large-grit acid-etched (SLA) or similar surfaces. Applying the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement, the MEDLINE, PubMed Central and Web of Science databases were searched for scientific articles in April 2020. The keywords used were “dental implants”, “bioactive surfaces”, “biofunctionalized surfaces”, and “osseointegration”, according to the question: “Do bioactive dental implant surfaces have greater osseointegration capacity compared with conventional implant surfaces?” Risk of bias was assessed using the Cochrane Collaboration tool. 128 studies were identified, of which only 30 met the inclusion criteria: 3 clinical trials and 27 animal studies. The average STROBE (STrengthening the Reporting of OBservational studies in Epidemiology) and ARRIVE (Animal Research: Reporting of In Vivo Experiments) scores were 15.13 ± 2.08 and 17.7±1.4, respectively. Implant stability quotient (ISQ) was reported in 3 studies; removal torque test (RTT)—in 1 study; intraoral periapical X-ray and microcomputed tomography radiological evaluation (RE)—in 4 studies; shear force (SF)—in 1 study; bone-to-implant contact (BIC)—in 12 studies; and BIC and bone area (BA) jointly—in 5 studies. All animal studies reported better bone-to-implant contact surface for bioactive surfaces as compared to control implants with a statistical significance of p < 0.05. Regarding the bioactive surfaces investigated, the best results were yielded by the one where mechanical and chemical treatment methods of the Ti surfaces were combined. Hydroxyapatite (HA) and calcium–phosphate (Ca–Ph) were the most frequently used bioactive surfaces. According to the results of this systematic review, certain bioactive surfaces have a positive effect on osseointegration, although certain coating biomolecules seem to influence early peri-implant bone formation. Further and more in-depth research in this field is required to reduce the time needed for osseointegration of dental implants.

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Section: Discussionmentioning

confidence: 99%

Bioactive Surfaces vs. Conventional Surfaces in Titanium Dental Implants: A Comparative Systematic Review

López-Valverde

Flores-Fraile

Ramı́rez

et al. 2020

JCM

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“…In our study, we have carried out an in vitro and in vivo study to compare two different surfaces in titanium grade IV and titanium grade V. The surface studied had undergone grit blasting treatment with alumina and double acid passivation for the modification of roughness. The treatment and its characteristics can be consulted in other publications of our group [20].…”

Section: Discussionmentioning

confidence: 99%

“…For the in vitro study, four groups were established to study titanium discs made of treated and untreated TiIV (TiIVT and TiIVNT) and treated and untreated TiV (TiVT and TiVNT). In previous studies published by our group, a greater description of the surface used and the control material used can be found [20].…”

Section: Preparation Of the Titanium Discmentioning

confidence: 99%

In Vitro and In Vivo Study of Titanium Grade IV and Titanium Grade V Implants with Different Surface Treatments

Díaz-Sánchez

de-Paz-Carrion

Serrera-Figallo

et al. 2020

Metals

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The aim of our study is to evaluate different implant surface treatments using TiIV and TiV in in vitro and in vivo studies. An in vitro study was established comprising four study groups with treated and untreated TiIV titanium discs (TiIVT and TiIVNT) and treated and untreated TiV titanium discs (TiVT and TiVNT). The surface treatment consisted in a grit blasting treatment with alumina and double acid passivation to modify surface roughness. The surface chemical composition and the surface microstructure of the samples were analyzed. The titanium discs were subjected to cell cultures to determine cell adhesion and proliferation of osteoblasts on them. The in vivo study was carried out on the tibia of three New Zealand rabbits in which 18 implants divided into three experimental groups were placed (TiIVT, TiIVNT, and TiVT). Micro-computed tomography (micro-CT) was performed to determine bone density around the implants. The results showed that cell culture had minor adhesion and cell proliferation in TiIVT and TiVT within the first 6 and 24 h. However, no differences were found after 48 h. No statistically significant differences were found in the in vivo micro-CT and histological study; however, there was a positive trend in bone formation in the groups with a treated surface. Conclusions: All groups showed a similar response to in vitro cell proliferation cultures after 48 h. No statistically significant differences were found in the in vivo micro-CT and histological study.

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“…Treatment with SLA (sand-blasted, large-grit, acid-etched) was based on coarse grain (250 to 500 mm) silicon particles blasted following an acid etching treatment using a mixture of hydrochloric and sulphuric acids on the titanium surfaces, obtaining a surface roughness (R a ) of 1.5 ± 0.2 µm [16].…”

Section: Methodsmentioning

confidence: 99%

“…Several authors have reported the advantages of this technique when it is applied for a few minutes before implant material utilization. This technique also yielded improved cell adhesion and protein adsorption in in vitro studies [11,12,13,14,15,16].…”

Section: Introductionmentioning

confidence: 99%

Human Osteoblast Cell Behaviour on Titanium Discs Treated with Argon Plasma

González-Blanco¹,

Rizo-Gorrita²,

Luna-Oliva³

et al. 2019

Materials

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(1) Background. Titanium is characterized by its biocompatibility and resistance to stress and fatigue. Treatment with argon plasma may favour growth of human osteoblasts with respect to cell adhesion and proliferation. The aim of this study was to analyse the behaviour of human osteoblasts (MG-63) on Grade IV and V titanium possessing a sand-blasted, acid-etched (SLA) surface. SLA is a widely used surface treatment to create micro- and macroretentions to enhance osteoconductive properties on the surface. (2) Methods. One group of each grade of titanium was decontaminated with argon plasma and compared. On each disc, 20 × 104 cells were cultivated for morphological analysis, study of cell viability (regarding a negative control [100% viability]) and mitochondrial energy balance. (3) Results. At 24 h titanium treated with SLA showed a higher percentage of cell viability (47.3 ± 8.1%) compared to titanium IV treated with argon plasma, which presented a percentage of 79.1 ± 1.1%. Grade V titanium treated with argon plasma presented a higher viability percentage 91.3 ± 3.0% whereas nontreated Grade V titanium presented 53.3 ± 4.0%. Cells cultivated on the surfaces with an argon-plasma treatment were enlarged in comparison to non-treated discs. The cells with smaller circularity with a greater spread and spindle shape were the ones cultivated on the Grade V titanium surface. Cells seeded on treated titanium IV and titanium V, treated or not, showed higher mitochondrial activity over nontreated titanium IV. (4) Conclusions. Cells cultivated on those Grade V titanium discs that were decontaminated with argon plasma presented higher levels of cell adhesion and proliferation, lower mitochondrial damage and a higher mean cell area compared to those not decontaminated with argon plasma.

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Superficial Characteristics of Titanium after Treatment of Chorreated Surface, Passive Acid, and Decontamination with Argon Plasma

Cited by 8 publications

References 48 publications

Bioactive Surfaces vs. Conventional Surfaces in Titanium Dental Implants: A Comparative Systematic Review

Bioactive Surfaces vs. Conventional Surfaces in Titanium Dental Implants: A Comparative Systematic Review

In Vitro and In Vivo Study of Titanium Grade IV and Titanium Grade V Implants with Different Surface Treatments

Human Osteoblast Cell Behaviour on Titanium Discs Treated with Argon Plasma

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