Bioactive Surfaces vs. Conventional Surfaces in Titanium Dental Implants: A Comparative Systematic Review

López-Valverde, Nansi; Flores-Fraile, Javier; Ramı́rez, Juan M.; Sousa, Bruno Macedo de; Herrero-Hernández, Silvia; López-Valverde, Antonio

doi:10.3390/jcm9072047

Cited by 44 publications

(30 citation statements)

References 79 publications

(240 reference statements)

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“…It is the result of successful osseointegration. The shape, material and surface of the implant used are important, as well as the technique of implant cradle preparation [ 4 , 20 , 26 , 32 , 46 , 47 , 48 ]. The variability of local soft and hard tissue conditions found in the cases of immediate implant insertion in the aesthetic region of the maxilla may result in different levels of difficulty and predictability of the treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Intensive development of scientific research concerning novel materials used for the production of dental implants and the modifications of their surfaces is currently being observed. The aim of this observation is to accelerate the increase of osteointegration with the patient’s bone [ 3 , 4 ]. The research activity, which is based on the strength and durability of osteointegration, results from the patient’s expectation to expand qualifying indications for dental implantology.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Anatomical Conditions of the Alveolar Process of the Anterior Maxilla in Terms of Immediate Implantation—Radiological Retrospective Case Series Study

Wychowański

Starzyńska

Osiak

et al. 2021

JCM

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The feasibility and the level of difficulty of immediate flapless implantation depend largely on the residual alveolar bone. The purpose of the study was to determine how often immediate flapless implantation in the anterior maxilla is feasible and assess the difficulty level using cone-beam computed tomography (CBCT) scans. A radiological retrospective case series study was conducted. In total, 1200 CBCT scans from 300 consecutive patients were analyzed with dedicated planning software. Immediate flapless implants were possible in 78.33% of cases. Drilling direction was either through the apex or the palatal slope. Bimodal was conducted in 9% of the cases; only through the apex in 13.08% of the cases and in 56.25% only in the slope. In 21.67%, immediate flapless implants were excluded. The feasibility and degree of difficulty differed statistically to the disadvantage of the lateral incisors compared to the central incisors. Drilling direction caused that BASE classification reflects the difficulty level of immediate implantation. CBCT is a helpful diagnostic tool for assessing the feasibility of immediate flapless implants due to the residual bone shape and volume. BASE classification helps to determine a challenge level that may also facilitate communication and result in comparison. The alveolar bone condition allows for immediate flapless implants in most cases in the aesthetic region of the maxilla, but they should be performed by an experienced specialist with regard to the bone and soft tissue quality.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Anatomical Conditions of the Alveolar Process of the Anterior Maxilla in Terms of Immediate Implantation—Radiological Retrospective Case Series Study

Wychowański

Starzyńska

Osiak

et al. 2021

JCM

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“…Among the different alternatives, coating implants with a layer of HA is one of the most used techniques. HA is a stable and biological form of calcium phosphate, as well as a non-inflammatory, and non-immunogenic material, which strengthens the organic matrix by mineralization [82]. It is composed of ions that normally exist in physiological environments and have excellent osteoconductive and osteointegration properties.…”

Section: Ha Layer and Nanocompositesmentioning

confidence: 99%

Surface Modified Techniques and Emerging Functional Coating of Dental Implants

et al. 2020

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Dental implants are widely used in the field of oral restoration, but there are still problems leading to implant failures in clinical application, such as failed osseointegration, marginal bone resorption, and peri-implantitis, which restrict the success rate of dental implants and patient satisfaction. Poor osseointegration and bacterial infection are the most essential reasons resulting in implant failure. To improve the clinical outcomes of implants, many scholars devoted to modifying the surface of implants, especially to preparing different physical and chemical modifications to improve the osseointegration between alveolar bone and implant surface. Besides, the bioactive-coatings to promote the adhesion and colonization of ossteointegration-related proteins and cells also aim to improve the osseointegration. Meanwhile, improving the anti-bacterial performance of the implant surface can obstruct the adhesion and activity of bacteria, avoiding the occurrence of inflammation related to implants. Therefore, this review comprehensively investigates and summarizes the modifying or coating methods of implant surfaces, and analyzes the ossteointegration ability and anti-bacterial characteristics of emerging functional coatings in published references.

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“…It is widely accepted that micro-roughness surface is beneficial for osteointegration between implant and new bone, because micro-roughness surface has a larger surface area [ 10 ]. Surface modification technologies, such as acid etching and sandblasting, are widely used in Ti-based orthopedic implants for clinical applications [ 11 ]. Compared with the micro-surface, the nano-surface has a greater influence on bone-related cell behaviors.…”

Section: Introductionmentioning

confidence: 99%

Enhanced osteogenesis of titanium with nano-Mg(OH)2 film and a mechanism study via whole genome expression analysis

Yao

Cheng

Zhou

et al. 2021

Bioactive Materials

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Titanium (Ti) has been the most widely used orthopedic implant in the past decades. However, their inert surface often leads to insufficient osteointegration of Ti implant. To solve this issue, two bioactive Mg(OH) 2 films were developed on Ti surfaces using hydrothermal treatment (Ti-M1# and Ti-M2#). The Mg(OH) 2 films showed nano-flake structures: sheets on Ti-M1# with a thickness of 14.7 ± 0.7 nm and a length of 131.5 ± 2.9 nm, and on Ti-M2# with a thickness of 13.4 ± 2.2 nm and a length of 56.9 ± 5.6 nm. Both films worked as Mg ions releasing platforms. With the gradual degradation of Mg(OH) 2 films, weakly alkaline microenvironments will be established surrounding the modified implants. Benefiting from the sustained release of Mg ions, nanostructures, and weakly alkaline microenvironments, the as-prepared nano-Mg(OH) 2 coated Ti showed better in vitro and in vivo osteogenesis. Notably, Ti-M2# showed better osteogenesis than Ti-M1#, which can be ascribed to its smaller nanostructure. Moreover, whole genome expression analysis was applied to study the osteogenic mechanism of nano-Mg(OH) 2 films. For both coated samples, most of the genes related to ECM-receptor interaction, focal adhesion, and TGF-β pathways were upregulated, indicating that these signaling pathways were activated, leading to better osteogenesis. Furthermore, cells cultured on Ti-M2# showed markedly upregulated BMP-4 gene expression, suggesting that the nanostructure with Mg ion release ability can better activate BMP-4 related signaling pathways, resulting in better osteogenesis. Nano-Mg(OH) 2 films demonstrated a superior osteogenesis and are promising surface modification strategy for orthopedic applications.

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Bioactive Surfaces vs. Conventional Surfaces in Titanium Dental Implants: A Comparative Systematic Review

Cited by 44 publications

References 79 publications

The Anatomical Conditions of the Alveolar Process of the Anterior Maxilla in Terms of Immediate Implantation—Radiological Retrospective Case Series Study

The Anatomical Conditions of the Alveolar Process of the Anterior Maxilla in Terms of Immediate Implantation—Radiological Retrospective Case Series Study

Surface Modified Techniques and Emerging Functional Coating of Dental Implants

Enhanced osteogenesis of titanium with nano-Mg(OH)2 film and a mechanism study via whole genome expression analysis

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