Superficial black onychomycosis due to <i>Neoscytalidium dimidiatum</i>

Chiacchio, Nilton Di; Noriega, Leandro Fonseca; Chiacchio, Nilton Gioia Di; Ocampo‐Garza, Jorge

doi:10.1111/jdv.14273

Cited by 8 publications

(11 citation statements)

References 10 publications

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“…3 Ungual phaeohyphomycosis are examples of non-dermatophytic onychomycosis, responsible for 1.5% to 18% of the cases of these infections. 4,5 Phaeohyphomycosis have increased their incidence in humans, both in immunocompromised and immunocompetent individuals, 6 and cause nail disease presenting as changes in color, thickness, detachment and onychodystrophy. 7 The genus Curvularia has a worldwide coverage that is mostly found in soil and in plants.…”

Section: Introductionmentioning

confidence: 99%

In vitro Antifungal Susceptibility of Agents for Superficial Phaeohyphomycosis

Pagnussat

Machado

Scarton

2020

SPDV

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The selection of fungal isolates resistant to available therapy associated with an increase in the number of immunosuppressed patients has contributed to the incidence of infections caused by dematiaceous fungi. Thus, this study evaluated the therapeutic efficacy of the main antifungal agents currently used in clinical practice in relation to Curvularia spp. and Hortaea werneckii from cases of superficial phaeohyphomycosis from southern Brazil. The susceptibility profile of amphotericin B, fluconazole, itraconazole, terbinafine and voriconazole against dematiaceous fungi (Curvularia lunata, C. pallescens and H. werneckii) was evaluated by microdilution in broth. Terbinafine showed greater efficacy against C. lunata - gemometric mean (GM = 0.38 μg/mL), C. pallescens (MIC = 0.125 μg/mL) and H. werneckii (GM = 0.031 μg/mL) when compared to the other antifungals tested. Most of species showed sensitivity to itraconazole and voriconazole, with a minimum inhibitory concentration (MIC) range from 1 - 8.0 μg/mL and 0.5 - 2.0 μg/mL, respectively. All isolates tested show low sensitivity to fluconazole (MIC range 4 - 16 μg/mL). Although itraconazole is considered gold standard, terbinafine has been showed to be a good alternative for the treatment of superficial phaeohyphomycosis. Lastly, antifungal susceptibility testing is essential to indicate the ideal therapy against these infections.

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Section: Introductionmentioning

confidence: 99%

In vitro Antifungal Susceptibility of Agents for Superficial Phaeohyphomycosis

Pagnussat

Machado

Scarton

2020

SPDV

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“…Overall, 5 contributions were not in the English language, and 7 did not include information regarding the frequency of dermoscopic signs of onychomycosis. Consequently, 33 records were included in this review [2,3,[12][13][14][15][16][17][18][19][20][21]4,[22][23][24][25][26][27][28][29][30][31]5,[32][33][34][6][7][8][9][10][11]. The process of selecting relevant articles is illustrated in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

“…The process of selecting relevant articles is illustrated in Figure 1. [4,7,11,16,17,23,[27][28][29][30][31][32]35], fungal culture [2,3,5,8,13,16,19,20,24,25,33,34], and/or histologic examination of nail plates [5,8,10,19,20,24].…”

Section: Resultsmentioning

confidence: 99%

“…Methods to diagnose onychomycosis were described in 27 of the included papers. The diagnosis was based on KOH examination [ 4 , 7 , 11 , 16 , 17 , 23 , 27 – 32 , 35 ], fungal culture [ 2 , 3 , 5 , 8 , 13 , 16 , 19 , 20 , 24 , 25 , 33 , 34 ], and/or histologic examination of nail plates [ 5 , 8 , 10 , 19 , 20 , 24 ].…”

Section: Resultsmentioning

confidence: 99%

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Dermoscopy of Onychomycosis: A Systematic Review

Litaiem

Mnif

Zéglaoui

2023

Dermatol Pract Concept

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Introduction: Onychomycosis represents a global burden accounting for about 50% of nail consultations. Several studies have tried to assess the dermoscopic features of onychomycosis. With the multiplication of papers, several “new” dermoscopic signs keep being added leading to some inconsistency in onychoscopic terminology. Objective: This study aimed to summarize the existing literature on the dermoscopic features of onychomycosis and propose a unified onychoscopic terminology. Methods: The literature search was performed using PubMed and Scopus databases up to October 30, 2021 to identify eligible contributions. In total, 33 records (2111 patients) were included. Results: The main dermoscopic signs of onychomycosis are “ruin appearance”, “longitudinal striae” and “spikes” on the proximal margin of onycholytic areas, with a specificity of 99.38%, 83.78%, and 85.64% respectively. The “aurora borealis” sign had the highest sensitivity and specificity. Conclusions: The current review provides a framework for issues related to the onychoscopic terminology of onychomycosis and is intended to serve as an aid for students, teachers, and researchers. We proposed a unifying terminology to describe dermoscopic signs of onychomycosis. Dermoscopic signs of onychomycosis show good specificity and are useful in distinguishing nail psoriasis, trauma, and onychomycosis. It helps differentiate fungal melanonychia from nail melanoma, nevi, and melanocytic activation.

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“…Currently, within this genus, four species are recognized: N. novaehollandiae , N. orchidacearum , N. oculus , and N. dimidiatum [2,3]. The first two species have been reported as phytopathogens, while N. oculus and N. dimidiatum have been associated to ocular or keratinized tissue (skin or nails) infections, which are indistinguishable from dermatophytosis [3,4,5]. Recently, it has been demonstrated that N. oculus can form biofilms and cause hemolysis [3].…”

Section: Introductionmentioning

confidence: 99%

ITS rDNA Gene Analysis Versus MALDI-TOF MS For Identification of Neoscytalidium dimidiatum Isolated from Onychomycosis and Dermatomycosis Cases in Medellin (Colombia)

et al. 2019

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Within the Neoscytalidium genus, N. dimidiatum, N. oculus, N. orchidacearum, and N. novaehollandiae have been recognized. Although these species are frequently found in soil, N. dimidiatum has been identified as an etiologic agent of onychomycosis or dermatomycosis, and N. oculus has been identified as an etiologic agent of an ocular lesion. All these species can be cultured in vitro, but their morphological identification by macroscopic and microscopic traits is difficult and imprecise due to their similarity. In this study, 34 isolates of Neoscytalidium spp. from 32 onychomycosis and two dermatomycosis cases in Medellin (Colombia) were identified at the species level using sequencing of the ITS1+5.8S+ITS2 nuclear rDNA region and MALDI-TOF mass spectrometry (MS). Neoscytalidium dimidiatum strain MUM 17.21 was used to construct the reference spectrum in the in-house library to identify the clinical isolates by MALDI-TOF MS. Additionally, N. dimidiatum PPC-216 and PLAB-055 strains were used to validate the in-house constructed reference spectra. Although four groups were observed in the dendrogram obtained from the proteins of each isolate profile, MALDI-TOF MS and sequencing results are in accordance, since all isolates were identified as N. dimidiatum.

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Superficial black onychomycosis due to Neoscytalidium dimidiatum

Cited by 8 publications

References 10 publications

In vitro Antifungal Susceptibility of Agents for Superficial Phaeohyphomycosis

In vitro Antifungal Susceptibility of Agents for Superficial Phaeohyphomycosis

Dermoscopy of Onychomycosis: A Systematic Review

ITS rDNA Gene Analysis Versus MALDI-TOF MS For Identification of Neoscytalidium dimidiatum Isolated from Onychomycosis and Dermatomycosis Cases in Medellin (Colombia)

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