Supercritical fluid (SCF)-assisted fabrication of carrier-free drugs: An eco-friendly welcome to active pharmaceutical ingredients (APIs)

Kankala, Ranjith Kumar; Xu, Pei‐Yao; Chen, Biao‐Qi; Wang, Shibin; Chen, Ai-Zheng

doi:10.1016/j.addr.2021.113846

Cited by 49 publications

(21 citation statements)

References 347 publications

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“…By considering these aspects, in this study, we demonstrate the fabrication of chitosan (CS)-modified indocyanine green (ICG) and LUT nanocomposites (ICG/LUT-CS) with promising traits via the supercritical antisolvent (SAS) approach and solution casting method. The innovation lies in the simple, fast and low-cost fabrication of nanocomposites toward addressing the challenges of synthesizing or modifying nanodrugs with high loading efficiency and integrating multiple functions in an “all-in-one” platform [ 37 ]. A mechanism based on photothermal-chemotherapy improved CS-based antibacterial activity to fight bacteria and biofilm under near-infrared (NIR) irradiation was proposed ( Fig.…”

Section: Introductionmentioning

confidence: 99%

Synergistic chemo-/photothermal therapy based on supercritical technology-assisted chitosan–indocyanine green/luteolin nanocomposites for wound healing

Kankala

et al. 2022

Regenerative Biomaterials

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Despite the success, it is highly challenging to battle against pathogenic biofilms-based chronic bacterial infections by conventional antibiotic therapy. Herein, we report a near-infrared (NIR)/acid-induced nanoplatform based on chitosan (CS)-coated indocyanine green (ICG, photosensitizer)/luteolin (LUT, a natural quorum sensing inhibitor) nanocomposites (ICG/LUT-CS) as antibacterial and antibiofilm agents for skin wound healing. Initially, the ICG/LUT nanoplatforms are prepared by the supercritical antisolvent technology (SAS) and coated with the CS layer. The obtained ICG/LUT-CS with ultra-high encapsulation efficiency exhibited more favorable photothermal conversion effects and improved NIR laser/acid dual-induced drug release behavior than individual modalities, achieving exceptional bacteria-killing and biofilm elimination effects. Moreover, the ICG/LUT-CS realized the synergetic effects of chemotherapy and photothermal therapy (PTT) outcomes for wound healing. Together, our findings provided an appealing strategy for the rapid preparation and future translational application of ICG/LUT-CS as an ideal agent for fighting against biofilm infections.

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Section: Introductionmentioning

confidence: 99%

Synergistic chemo-/photothermal therapy based on supercritical technology-assisted chitosan–indocyanine green/luteolin nanocomposites for wound healing

Kankala

et al. 2022

Regenerative Biomaterials

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“…Recently, many pure nanomedicines without chemical binding have been structured by a supercritical fluids antisolvent method. With the help of supercritical carbon dioxide, supercritical fluids antisolvent can realize self-assembly of clinical medicines into pure nanomedicines without any additive ingredients or solvents . For instance, Chen’s group prepared a series of pure nanodrugs via supercritical antisolvent processing, solving poor solubility and promoting the bioavailability of drugs such as astragaloside IV, gambogic acid, and dihydromyricetin. − In this procedure, some factors ( e.g., temperature, pressure, solvent and etc.)…”

Section: Interventional Fluorescence Image-guided Surgical Navigation...mentioning

confidence: 99%

Recent Advances in Interventional Fluorescence Imaging: Toward the Precise Visualization of Transarterial Mini-Invasive Delivery Systems

et al. 2023

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Interventional fluorescence imaging has gradually developed into a promising imaging strategy for the diagnosis of diseases in clinic. This strategy could benefit interventional targeted treatment because of the clear display of microstructures at the margins and boundaries. There are some stranded crucial issues in clinical application: (i) fast clearance of fluorescence probes; (ii) light instability and photobleaching; and (iii) residual and microsatellite lesions. The development of superstable homogeneous intermixed formulation technology (SHIFT) can solve the aforementioned clinical problems for precision hepatectomy. Interventional fluorescence imaging based on SHIFT-prepared product has some advantages such as (i) strong stability, (ii) greatly extending imageable time window, and (iii) precisely visualizing microsatellite lesions. In this Account, we overview our current progress in interventional fluorescence imaging based on SHIFT method for surgical resection following long-lasting embolization conversion. To greatly realize interventional fluorescence imaging, we summarize clinical and preclinical application of interventional fluorescence imaging in a transarterial delivery system. Indeed, compared with conventional fluorescence imaging, interventional fluorescence imaging possesses non-negligible strengths on improved intensity in target location and step-down systemic toxicity. Unfortunately, a challenging issue is that immobile fluorescence performance is difficult to maintain after long-time embolization, resulting in a failed hepatectomy. On this basis, associated with our previous research, SHIFT was proposed and developed. Thus, we detailedly introduce and account the development and preponderance of SHIFT on interventional fluorescence imaging. Predictably, after lengthy embolization, its lightful fluorescence was still observable in tumor targets of a clinical trial. To regulate the fluorescence rendering of microsatellite lesion, SHIFT combining with pure nanoprobes (nanoICG) occurs, namely SHIFT nanoICG, and we dwell on its performance in transarterial invasive surgical navigation and its clinical application under interventional fluorescence imaging compared with conventional indocyanine green (ICG) formulations. Amazingly, the SHIFT nanoICG brings us an extraordinary imaging consequence for deep-seated tumor tissues and imperceptible microsatellite lesions. Finally, we offer perspectives on the future tendency of interventional imaging-guided SHIFT products in clinical translation such as chemoembolization, radioembolization, and immunotherapy. Actually, these directions have been underway for some time, and even relative products are already applied for clinical trials, exhibiting effective therapeutic outcomes. Our green high-performance SHIFT products are concentrated on meeting clinical needs and solving clinical problems, breaking through the cure limitations of patients with advanced diseases. Thus, the discovery offers insight into the development and superiority of SHIFT product...

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“…In addition, CO 2 is nontoxic, nonflammable, and inexpensive. SC-CO 2 is a solvent approved generally recognized as safe (GRAS) by the United States Food and Drug Administration (US-FDA) [40,41]. It is also considered a green solvent and natural material withdrawn from the environment.…”

Section: Supercritical Fluid (Scf)mentioning

confidence: 99%

“…Although there have been reports that the improved SFEE process has many advantages for various pharmaceutical applications, there is a need to develop it into a GMP-compliant facility with product reproducibility to achieve commercial mass production. In the pharmaceutical manufacturing processes, GMP is necessary to regulate the potential chemical and mechanical hazards [40]. However, large-scale research to establish plant facilities of SFEE suitable for GMP that can produce micro-/nanoparticles on an actual commercial scale is insufficient and has not yet been completed.…”

Section: Expert Opinions and Perspectivesmentioning

confidence: 99%

Pharmaceutical Applications of Supercritical Fluid Extraction of Emulsions for Micro-/Nanoparticle Formation

Park

Kim

et al. 2021

Pharmaceutics

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Micro-/nanoparticle formulations containing drugs with or without various biocompatible excipients are widely used in the pharmaceutical field to improve the physicochemical and clinical properties of the final drug product. Among the various micro-/nanoparticle production technologies, emulsion-based particle formation is the most widely used because of its unique advantages such as uniform generation of spherical small particles and higher encapsulation efficiency (EE). For this emulsion-based micro-/nanoparticle technology, one of the most important factors is the extraction efficiency associated with the fast removal of the organic solvent. In consideration of this, a technology called supercritical fluid extraction of emulsions (SFEE) that uses the unique mass transfer mechanism and solvent power of a supercritical fluid (SCF) has been proposed to overcome the shortcomings of several conventional technologies such as solvent evaporation, extraction, and spray drying. This review article presents the main aspects of SFEE technology for the preparation of micro-/nanoparticles by focusing on its pharmaceutical applications, which have been organized and classified according to several types of drug delivery systems and active pharmaceutical ingredients. It was definitely confirmed that SFEE can be applied in a variety of drugs from water-soluble to poorly water-soluble. In addition, it has advantages such as low organic solvent residual, high EE, desirable release control, better particle size control, and agglomeration prevention through efficient and fast solvent removal compared to conventional micro-/nanoparticle technologies. Therefore, this review will be a good resource for determining the applicability of SFEE to obtain better pharmaceutical quality when researchers in related fields want to select a suitable manufacturing process for preparing desired micro-/nanoparticle drug delivery systems containing their active material.

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Supercritical fluid (SCF)-assisted fabrication of carrier-free drugs: An eco-friendly welcome to active pharmaceutical ingredients (APIs)

Cited by 49 publications

References 347 publications

Synergistic chemo-/photothermal therapy based on supercritical technology-assisted chitosan–indocyanine green/luteolin nanocomposites for wound healing

Synergistic chemo-/photothermal therapy based on supercritical technology-assisted chitosan–indocyanine green/luteolin nanocomposites for wound healing

Recent Advances in Interventional Fluorescence Imaging: Toward the Precise Visualization of Transarterial Mini-Invasive Delivery Systems

Pharmaceutical Applications of Supercritical Fluid Extraction of Emulsions for Micro-/Nanoparticle Formation

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