Supercritical fluid extraction and convergence chromatographic determination of parthenolide in Tanacetum parthenium L.: Experimental design, modeling and optimization

Végh, Krisztina R.; Alberti, Ágnes; Riethmüller, Eszter; Tóth, Anita; Béni, Szabolcs; Kéry, Ágnes

doi:10.1016/j.supflu.2014.07.029

Cited by 15 publications

(4 citation statements)

References 20 publications

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“…During the period of 18 months, while the investigated sam-ples were stored and kept under storage conditions mimicking the usual manner of keeping the plant raw material (leaves, flowers and herbs) and dry extracts, adopting the managing quality to prevent degradation, contamination, and crosscontamination, in appropriate containers, it could be observed that in the extract commercially available at the market the parthenolide content decreased less than 0.1%, in contrast to the investigated T. parthenii drugs (leaves, flowers and aerial parts), in which a greater percentage of parthenolide content decrease was noticed (Table 1). Regarding leaves, Végh et al (2014) demonstrated that the highest content of parthenolide was found in leaves collected before flowering compared to the leaves collected during the flowering period. That implies that with the beginning of the flowering period a decrease of parthenolide contents in the leaves arises.…”

Section: Resultsmentioning

confidence: 96%

Variation of parthenolide and phenolic compounds content in different parts of Tanacetum parthenium (L.) Schulz Bip., Asteraceae during 18 months storage

Tadić¹,

Živković²,

Bigović³

et al. 2019

Lekovite sirovine

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Feverfew (Tanacetum parthenium (L.) Schulz Bip., Asteraceae), a medicinal plant with a long tradition in European folk medicine, has been used to treat headache, fever, rheumatism, asthma, stomach pains, and other conditions related to inflammation. Although feverfew is often used for migraine headaches, numerous literature data stated the inconclusiveness regarding its efficacy. Namely, there is the discrepancy between the stated and the found quantity of the carrier of the mentioned activity (parthenolide) in the herbal products containing feverfew or its extracts. Based on the EMA monographs, it is evident that the feverfew phytopreparation might be designed from the raw herbal material, adequately prepared. Therefore, in this work we investigated the variation of the parthenolide content in different parts of this plant during 18 months storage in order to enable the data regarding the possible use of the powered plants in preparations aimed for migraine prophylaxis. Besides, the total phenolic compound content was determined, as well. The results revealed that the content of parthenolide decreased during the investigated period. In contrast, parthenolide content in the commercially available extract did not change during the time of investigation. Different particle size of the tested drugs in our investigation seemed to influence only total flavonoid content. Total flavonoids and total phenolics content remained the same during 18 months of storage.

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Section: Resultsmentioning

confidence: 96%

Variation of parthenolide and phenolic compounds content in different parts of Tanacetum parthenium (L.) Schulz Bip., Asteraceae during 18 months storage

Tadić¹,

Živković²,

Bigović³

et al. 2019

Lekovite sirovine

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“…Zhou et al indicate that acetonitrile with 10% of water (v/v) using bottle stirring methods extracted the highest amount of parthenolide (930 mg/100 g raw material) from feverfew [205]. Furthermore, the isolation of parthenolide from feverfew with supercritical carbon dioxide extraction was reported [206][207][208]. Cretnik et al compared the performance of conventional and high-pressure extraction techniques for separation of parthenolide from feverfew.…”

Section: Parthenolidementioning

confidence: 99%

Plant-Derived Natural Products in Cancer Research: Extraction, Mechanism of Action, and Drug Formulation

et al. 2020

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Cancer is one of the main causes of death globally and considered as a major challenge for the public health system. The high toxicity and the lack of selectivity of conventional anticancer therapies make the search for alternative treatments a priority. In this review, we describe the main plant-derived natural products used as anticancer agents. Natural sources, extraction methods, anticancer mechanisms, clinical studies, and pharmaceutical formulation are discussed in this review. Studies covered by this review should provide a solid foundation for researchers and physicians to enhance basic and clinical research on developing alternative anticancer therapies.

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“…The extracts of T. parthenium L. contain a diverse range of compounds. Most of the studies report the analysis and quantitation of sesquiterpene lactones (parthenolide, santamarin, canin) and flavonoid content (santin, luteolin, apigenin) of the plant (Awang et al ., ; González et al ., ; Harborne et al ., ; Végh et al ., ). There are several reports on the composition of the essential oil of feverfew (Mirjalili et al ., ; Hendriks et al ., ; Banthrope et al ., ; Akpulat et al ., ; Haziri et al ., ; Izadi et al ., ), in which the main components were found to be camphor, camphene and trans‐ chrysanthenyl acetate.…”

Section: Introductionmentioning

confidence: 97%

Convergence chromatographic determination of camphor in the essential oil of Tanacetum parthenium L.

Végh

Riethmüller

Tóth

et al. 2016

Biomedical Chromatography

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Feverfew (Tanacetum parthenium L., Asteraceae) is a perennial medicinal plant which has been used to alleviate the symptoms of migraine, headache and rheumatoid arthritis and possesses numerous pharmacological activities. An ultra-high-performance supercritical fluid chromatographic method (UHPSFC) was developed and validated in accordance with the International Conference on Harmonization guidelines in order to determine the camphor content of the volatile oil, which was accurate, precise, robust and selective. The method was validated for specificity, accuracy (100.2%), repeatability and intermediate precision, linearity (r > 0.999), limit of detection (2.055 μg/mL), limit of quantification (6.228 μg/mL) and robustness. The common range of accuracy and linearity was between 0.125 and 1.000 mg/mL. Steam distillation was carried out in order to study the essential oil yield of three different T. parthenium L. samples originating from Hungarian medicinal herb collections. The camphor content of the essential oils from the aerial parts of feverfew samples from different origin was compared. Although the composition of the essential oil is well reported, a validated quantitative UHPSFC method for the determination of the constituents is presented herein for the first time.

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Supercritical fluid extraction and convergence chromatographic determination of parthenolide in Tanacetum parthenium L.: Experimental design, modeling and optimization

Cited by 15 publications

References 20 publications

Variation of parthenolide and phenolic compounds content in different parts of Tanacetum parthenium (L.) Schulz Bip., Asteraceae during 18 months storage

Variation of parthenolide and phenolic compounds content in different parts of Tanacetum parthenium (L.) Schulz Bip., Asteraceae during 18 months storage

Plant-Derived Natural Products in Cancer Research: Extraction, Mechanism of Action, and Drug Formulation

Convergence chromatographic determination of camphor in the essential oil of Tanacetum parthenium L.

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