Supercritical fluid (CO2+ethanol) extraction of chlorophylls and carotenoids from Chlorella sorokiniana: COSMO-SAC assisted prediction of properties and experimental approach

Morcelli, Allan Valcareggi; Cassel, Eduardo; Vargas, Rubem Mário Figueiró; Rech, Rosane; Marcílio, Nilson Romeu

doi:10.1016/j.jcou.2021.101649

Cited by 27 publications

(8 citation statements)

References 55 publications

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“…Hydrocarbon content of B. braunii was determined by using hexane [ 24 , 40 ]. Morcelli et al by using ethyl acetate and methanol measured the concentration of violaxanthin, lutein and total carotenoids for C. sorokiana [ 49 ]. Total carotenoid content was determined by employing acetone for C. vulgaris [ 40 ], N. gaditana [ 97 ], Nannochloropsis sp.…”

Section: Other Extraction Methodsmentioning

confidence: 99%

Recent Advances in Supercritical CO2 Extraction of Pigments, Lipids and Bioactive Compounds from Microalgae

et al. 2023

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Supercritical CO2 extraction is a green method that combines economic and environmental benefits. Microalgae, on the other hand, is a biomass in abundance, capable of providing a vast variety of valuable compounds, finding applications in the food industry, cosmetics, pharmaceuticals and biofuels. An extensive study on the existing literature concerning supercritical fluid extraction (SFE) of microalgae has been carried out focusing on carotenoids, chlorophylls, lipids and fatty acids recovery, as well as the bioactivity of the extracts. Moreover, kinetic models used to describe SFE process and experimental design are included. Finally, biomass pretreatment processes applied prior to SFE are mentioned, and other extraction methods used as benchmarks are also presented.

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Section: Other Extraction Methodsmentioning

confidence: 99%

Recent Advances in Supercritical CO2 Extraction of Pigments, Lipids and Bioactive Compounds from Microalgae

et al. 2023

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“…Recently, supercritical CO 2 extraction has demonstrated great success for recovering carotenoids from algae. 128,129 However, the low polarity of supercritical CO 2 makes it unfavorable for extracting polar compounds. Addition of polar cosolvents such as ethanol into supercritical CO 2 helps extend the categories of extractable bioactive compounds from algae.…”

Section: Main Challengesmentioning

confidence: 99%

“…Conventional extraction approaches using a mixture of organic solvents such as hexane–methanol and chloroform–methanol lead to a big solvent consumption, and thus downstream aqueous waste treatment is required. Recently, supercritical CO 2 extraction has demonstrated great success for recovering carotenoids from algae. , However, the low polarity of supercritical CO 2 makes it unfavorable for extracting polar compounds. Addition of polar cosolvents such as ethanol into supercritical CO 2 helps extend the categories of extractable bioactive compounds from algae.…”

Section: Main Challengesmentioning

confidence: 99%

Recent Advances in Algae-Derived Biofuels and Bioactive Compounds

Feng

Kang

Salaudeen

et al. 2022

Ind. Eng. Chem. Res.

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Owing to the declining reserve of fossil resources as well as more concerns on climate change, and essential energy security, and especially the broad consensus on carbon neutralization, it is significantly critical to develop renewable and sustainable energy and chemicals. Algae as alternative resources can be applied to produce biofuels and biochemicals. Among them, algae-derived natural pigments exhibit high market value due to their uses in pharmaceutical and food industries. As a result of the developments of engineering tools, it is feasible to scale up algal processing and applications. Prior to the industrial implementation, life cycle assessment is required to ensure the environmental feasibility of algae-based biofuels and biochemicals. In this article, recent advances in processing algae for liquid, gas, and solid fuels are reviewed. New approaches for enhancing the natural pigment accumulation are also discussed. Recent studies on life cycle assessment of algae-based biofuels and biochemicals, as well as the main challenges faced by the algal biorefinery, are discussed in this manuscript.

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“…Additionally, the solubility of gallic acid in solvents with various water/ethanol, water/acetic acid, and acetic acid/ethanol ratios were measured at 298.15 K, 318.15 K, and 338.15 K, respectively. The measured solubility data were compared with the predicted results using the Hansen solubility parameter method [34], which is a simple and long-standing approach with a theoretical framework, and COSMO-SAC [28], which is widely used to judge the affinity between the solute and the solvent [28,[35][36][37].…”

Section: Introductionmentioning

confidence: 99%

Solubility of Gallic Acid in Single and Mixed Solvents

Park,

Lee

2024

Separations

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Gallic acid, known for its biological activity contributing to human health, including antioxidant, anti-inflammatory, anticancer, and antimutagenic properties, was the focus of this study. The solubility of gallic acid was experimentally measured in pure and mixed solvents of water, ethanol, and acetic acid and predicted using the COSMO-SAC model and the Hansen solubility parameter. The Hansen solubility parameter method predicted a higher solubility of gallic acid in pure water than in pure ethanol, and in a mixed solvent, it predicted the maximum solubility at 80% water content, showing different results from the experimental data trends. However, using the molar volume obtained from COSMO calculations resulted in a tendency that matched the experimental results. The results revealed higher solubility in ethanol compared to water, with the solubility in mixed solvent falling within the range between them. Using the same method, the Hansen solubility parameter obtained was applied to acetic acid/water and acetic acid/ethanol mixtures, and similar trends were observed compared to experimental data. In particular, gallic acid in the acetic acid/water mixture solvent exhibited maximum solubility, and this phenomenon was well-predicted. As the temperature increased, solubility in both pure and mixed solvents also increased. While the COSMO-SAC model effectively captured this trend, the predicted solubility values were slightly lower than the experimental data. The solubility trends depending on solvent types were confirmed by comparing the σ-profiles of each compound. The σ-profile of gallic acid closely resembled that of ethanol, and this result led to higher solubility than water and acetic acid. The maximum solubility in ethanol/water and acetic acid/water mixed solvents could be anticipated when two solvents with significant differences in their σ-profiles are mixed in an appropriate ratio.

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Supercritical fluid (CO2+ethanol) extraction of chlorophylls and carotenoids from Chlorella sorokiniana: COSMO-SAC assisted prediction of properties and experimental approach

Cited by 27 publications

References 55 publications

Recent Advances in Supercritical CO2 Extraction of Pigments, Lipids and Bioactive Compounds from Microalgae

Recent Advances in Supercritical CO2 Extraction of Pigments, Lipids and Bioactive Compounds from Microalgae

Recent Advances in Algae-Derived Biofuels and Bioactive Compounds

Solubility of Gallic Acid in Single and Mixed Solvents

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