Supercritical Fluid Chromatography

Taylor, Larry T.

doi:10.1021/ac800482d

Cited by 48 publications

(15 citation statements)

References 76 publications

(74 reference statements)

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“…The characteristics of these alkaloids are higher boiling points and lower vapor pressures. Thin-layer chromatography (TLC), high performance liquid chromatography (HPLC) [13–15], high performance capillary electrophoresis (HPLE) [16], and supercritical fluid chromatography [17] were often employed in the analysis of these alkaloids. Liquid chromatography-mass spectrometry (LC/MS) and multistage spectrometry (MS n ) were also reported in some literatures [18–20].…”

Section: Introductionmentioning

confidence: 99%

Alkaloids in Processed Rhizoma Corydalis and Crude Rhizoma Corydalis Analyzed by GC/MS

Guo

Cai

et al. 2014

Journal of Analytical Methods in Chemistry

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The alkaloids in the processed Rhizoma Corydalis and the crude Rhizoma Corydalis were qualitatively and semiquantitatively analyzed using gas chromatography-mass spectrometry (GC/MS) method. The processing herb drug procedure was carried out according to the standard method of Chinese Pharmacopoeia. The samples were extracted using Soxhlet extractor with different solvents: methanol and acetone. The extraction effect on different solvents was investigated. The results showed that 11 kinds of alkaloids were identified from the crude Rhizoma Corydalis and only two were from the processed Rhizoma Corydalis. A total of 13 kinds of alkaloids were all based on two backbones. The alkaloids in the processed sample were less than those in the crude Rhizoma Corydalis significantly, while almost the corydaline has been changed in conformation after the sample had undergone processing, which provided support for the conclusion of reducing toxicity when the herbal medicine having been undergone a traditional drugs treatment process.

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Section: Introductionmentioning

confidence: 99%

Alkaloids in Processed Rhizoma Corydalis and Crude Rhizoma Corydalis Analyzed by GC/MS

Guo

Cai

et al. 2014

Journal of Analytical Methods in Chemistry

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“…Some important reviews of the field were published by Taylor in 2008 [58], in 2009 [59] and in 2010 [74]. In these works, the author provides a yearly overview of the literature dedicated to SFC, focusing on various topics such as analytical scale SFC for both chiral and achiral, hyphenation with mass-spectrometry, instrumental improvements, trends in method development and preparative SFC.…”

Section: Particular Literature Overviewmentioning

confidence: 99%

“…Indeed, its applications are expanding inside several domains and especially in the pharmaceutical field where numerous researches were published. Thus, SFC was demonstrated to be useful for drug analysis [18]- [29], drug discovery [30]- [35], impurity profiling [26] [27] [31] [36]- [39], quantitative applications [40], bioanalysis [41]- [48], metabolic/metabolomics studies [49]- [55], chiral separations [56] [57], drug screening and preparative purposes at various stages [58]- [60]. However, the interest of SFC is not limited to pharmaceutical applications, other fields of application being polymer sciences [61] [62], petroleum industry [63]- [65], food analyses [66]- [69], and for various industrial processes [70]- [72].…”

Section: Introductionmentioning

confidence: 99%

Overview of the Analytical Lifecycle of Supercritical Fluid Chromatography Methods

Andri

Dispas

Marini

et al. 2016

AJAC

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In recent times, the overall interest over Supercritical Fluid Chromatography (SFC) is truly growing within various domains but especially for pharmaceutical analysis. However, in the best of our knowledge modern SFC is not yet applied for drug quality control in the daily routine framework. Among the numerous reported SFC methods, none of them could be found to fully satisfy to all steps of the analytical method lifecycle. Thereby, the present contribution aims to provide an overview of the current and past achievements related to SFC techniques, with a targeted attention to this lifecycle and its successive steps. The included discussions were therefore structured accordingly and emphasizing the analytical method lifecycle in accord with the International Conference on Harmonisation (ICH). Recent and important scientific outputs in the field of analytical SFC, as well as instrumental evolution, qualification strategies, method development methodologies and discussions on the topic of method validation are reviewed.

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“…The technology was developed in the early 1990s for Prep but took some time to reach the market. 29 The use of CO 2 as the main component of the mobile phase is very attractive as it is an inexpensive raw material and is easy to discard. Because the CO 2 is the side product of other industries and is not generated by the separation, the SFC process is considered green as it uses less organic solvent than conventional batch chromatography.…”

Section: Sfcmentioning

confidence: 99%

9.08 Use of Industrial Scale Chromatography in Pharmaceutical Manufacturing

Dapremont

2014

Comprehensive Organic Synthesis II

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Supercritical Fluid Chromatography

Cited by 48 publications

References 76 publications

Alkaloids in Processed Rhizoma Corydalis and Crude Rhizoma Corydalis Analyzed by GC/MS

Alkaloids in Processed Rhizoma Corydalis and Crude Rhizoma Corydalis Analyzed by GC/MS

Overview of the Analytical Lifecycle of Supercritical Fluid Chromatography Methods

9.08 Use of Industrial Scale Chromatography in Pharmaceutical Manufacturing

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