Supercritical Fluid Applications in Advanced Materials Processing

Wagner, Richard; Krukonis, Val J.; Coffey, Michael P.

doi:10.1557/proc-121-711

Cited by 3 publications

(3 citation statements)

References 2 publications

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“…The concept of RESS was first described by pioneers Hannay and Hogarth 120 years ago and developed by Krukonis et al RESS involves heavy components, such as solid pharmaceuticals, and light components, such as SC CO 2 . In RESS, a SC CO 2 stream is saturated with a solute to be crystallized by passing it through a bed packed with a solute.…”

Section: Methodsmentioning

confidence: 99%

Nanoparticle-Based Drugs and Formulations: Current Status and Emerging Applications

Kumar

Dalvi

Siril

2020

ACS Appl. Nano Mater.

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In the foreseeable future, the pharmaceuticals market, nanomedicine, and healthcare systems will largely depend on the drug nanoparticle formulation technology. Perceiving this, scientists around the world are reporting each day a significant amount of research work focusing on the fundamentals of nanocrystallization and performance enhancement. The nanocrystallization strategies' industrial applications mainly depend on the ability of the technique to produce nanoparticles of active pharmaceutical ingredients (APIs) with controlled particle size, narrow size distribution, stability, reproducibility, high solid loading, scale-up feasibility, suitabilty for a range of APIs, and cost-effectiveness. There are plenty of reports witnessing performance improvements of nanodrugs. The harmony between the nanocrystallization strategies, performance of nanodrugs, scale-up producibility, and industrial challenges remains an untold and unsummarized story in the field of pharmaceutical nanotechnology. This review is devoted to comprehensively discussing the promising nanocrystallization strategies, fundamental concepts, and promising results of nanodrugs. We have also reviewed the progress toward commercialization and market based on nanodrugs, further challenges toward industrial application, and the future direction of pharmaceutical technologies and their impact on the future of the healthcare system.

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Section: Methodsmentioning

confidence: 99%

Nanoparticle-Based Drugs and Formulations: Current Status and Emerging Applications

Kumar

Dalvi

Siril

2020

ACS Appl. Nano Mater.

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“…Moreover, impregnation of three dimension mats of carbon fibers by polycarbosilane is claimed to lead to a drastic improved C-C alloy properties (fatigue and oxidation under high stress) [20].…”

Section: New Applicationsmentioning

confidence: 99%

“…On the other hand, as soon as decompression, the solute precipitates and does not follow the fluid exiting from the matrix. Many impregnation applications have been reported including polymer-wood composite preparation by monomer impregnation followed by in-situ polymerization [36], pharmaceutical patches, sponges, and catheters [42,43] or carbon-carbon or ceramic precursors [20,44]. We recently obtained attractive results on paper impregnation for development of a deacidification and reinforcement process for damaged books [45], and patented a new process for on-line impregnation after extraction, especially attractive for natural products processing as one sole operation leads directly to the usable product (active on excipient powder) [46].…”

Section: Protein Encapsulated In a Lipid Excipientmentioning

confidence: 99%

Supercritical Fluid Applications: Industrial Developments and Economic Issues

Perrut

2000

Ind. Eng. Chem. Res.

321

153

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:This lecture intends to give a brief overview of the status of Supercritical Fluid industrial applications and to draw some prospective trends. Based on the know-how gathered by SEPAREX along these 20 last years of work on many supercritical fluids applications and manufacture of more than 80 plants at pilot scale or industrial scale, economic evaluations and comments about design, maintenance and operation of supercritical fluid plants will be presented. Present status of industrial applications :During the last two decades, except for processes used in the petroleum industry -that are not in the scope of this lecture -industrial applications have been mostly developed for natural products extraction/fractionation, both for food and pharmaceutical products (Hundreds of references are available in literature ; I advice the reader to begin by [1][2][3][4][5][6][7]) . At present time, these applications are still continuing to slowly spread worldwide with a wide potential of capacity increase as high quality products are more and more required and environment/health problems are more and more taken into account.• Extraction (SFE) from solid materials is the most developed application, mainly for food products (coffee, tea,…), food ingredients (hops and aromas, colorants, vitamin-rich extracts, specific lipids, …) and nutraceuticals/ phytopharmaceuticals. Residual organic solvent or other impurities, like pesticides, are also removed from final active compounds or food ingredients/nutraceuticals (like ginseng) at large scale [1][2][3][4][5][6][7]. I estimate the number of industrial-scale SFE units now under operation on natural products about 100 (or slightly over) with a growth of about 10% per year.Some "niches" applications concern high-added value products, like delipidation of bones for allografts preparation, or specialty polymer stripping.• Fractionation (SFF) of liquid mixtures are designed to take profit of the very high selectivity of supercritical fluids with attractive costs related to continuous operation ; nevertheless, few industrial units are now used for aromas production from fermented and distilled beverages, fractionation of polyunsaturated fatty acids and polar lipids, polymer fractionation (specialty lubricants, pharmaceuticals,…), recovery of active compounds from fermentation broths, pollution abatement on aqueous streams,….• Preparative Scale Supercritical Fluid Chromatography (PSFC) is operated for ultimate fractionation of very similar compounds, especially for lipids like polyunsaturated fatty acids in a few large-scale units.•

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Hybrid Composites

Chung¹

1994

Carbon Fiber Composites

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Supercritical Fluid Applications in Advanced Materials Processing

Cited by 3 publications

References 2 publications

Nanoparticle-Based Drugs and Formulations: Current Status and Emerging Applications

Nanoparticle-Based Drugs and Formulations: Current Status and Emerging Applications

Supercritical Fluid Applications: Industrial Developments and Economic Issues

Hybrid Composites

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