Supercritical Extraction and Separation of Antioxidants from Residues of the Wine Industry

Garcí-Abarrio, S.M.; Marqués, J.L.; Scognamiglio, Mariarosa; Porta, Giovanna Della; Reverchon, Ernesto; Mainar, Ana M.; Urieta, José S.

doi:10.1016/j.proeng.2012.07.570

Cited by 7 publications

(3 citation statements)

References 5 publications

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“…Supercritical fluid processes have been proposed to produce particles of micro and nanometric size [30], composite microparticles [31][32][33][34][35], and, in particular, microparticles for aerosol delivery [36][37][38][39][40][41]. Supercritical Antisolvent or Supercritical Antisolvent Extraction techniques, in which supercritical CO 2 is used to remove the solvent from a solution in order to obtain precipitation of a powder, have been used for the production of antioxidant microparticles [42,43], mainly loaded in PVP microparticles [34] and for fractionation of antioxidants from natural matrices [44][45][46][47][48][49][50].…”

Section: Introductionmentioning

confidence: 99%

Supercritical Antisolvent Technique for the Production of Breathable Naringin Powder

et al. 2022

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Flavonoids are polyphenolic compounds largely present in fruits and vegetables possessing antioxidant properties, anti-inflammatory and antibacterial activities. Their use in clinical practice is very poor due to their low bioavailability, susceptibility to oxidation and degradation. Moreover, their slight solubility in biological fluids and a consequent low dissolution rate leads to an irregular absorption from solid dosage forms, even though, anti-inflammatory formulations could be used as support for several disease treatment, i.e. the COVID-19 syndrome. To improve flavonoid bioavailability particle size of the powder can be reduced to make it breathable and to promote the absorption in the lung tissues. Supercritical fluid based antisolvent technique has been used to produce naringin particles, with size, shape and density as well as free flowing properties able to fit inhalation needs. The dried particles are produced with the removal of the solvent at lower temperatures compared to the most used traditional micronization processes, such as spray drying. The best breathable fraction for naringin particles is obtained for particles with a d50~7 µm manufactured at 35 °C-150 bar and at 60 °C-130 bar, corresponding to 32.6% and 36.7% respectively. The powder is produced using a high CO2 molar fraction (0.99) that assure a better removal of the solvent. NuLi-1 cell line of immortalised bronchial epithelial cells adopted to evaluate powder cytotoxicity indicated after 24 h absence of toxicity at concentration of 25 µM.

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Section: Introductionmentioning

confidence: 99%

Supercritical Antisolvent Technique for the Production of Breathable Naringin Powder

et al. 2022

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“…However, vegetable matter has a very complex structure and composition, and the organic solvents, as a rule, extract numerous compound families showing a limited selectivity towards the compound/s of interest. For these reasons, alternative extraction processes have been proposed in the scientific literature and, in some cases, on the industrial scale, that are based on the use of supercritical carbon dioxide (SC‐CO 2 ) …”

Section: Introductionmentioning

confidence: 99%

“…For these reasons, alternative extraction processes have been proposed in the scientific literature and, in some cases, on the industrial scale, that are based on the use of supercritical carbon dioxide (SC-CO 2 ). [1][2][3][4][5][6][7] In the specific case of Artemisia annua L., the extract contains artemisinin, a sesquiterpene lactone, and its derivatives (mainly artemisin and dehydroartemisinin) that show a strong antimalaric activity, particularly against drug resistant strains of Plasmodium falciparum. It has also been demonstrated that these extracts are antifibrotic 8 and have a potent cytotoxic activity against some kinds of tumor.…”

Section: Introductionmentioning

confidence: 99%

Artemisia annua organic solvent extract, processed by supercritical CO₂

Baldino

Reverchon

2018

J of Chemical Tech & Biotech

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BACKGROUND Artemisia annua L. extraction is traditionally performed using hexane; the process is simple, but not selective. In this work, a strategy to concentrate artemisinin and the other similar active principles in the final extract is proposed, combining cheapness of maceration and selectivity of SC‐CO2 processing. RESULTS Hexane extraction produced a solid, waxy extract with a yield of 3.3% w/w with respect to the starting vegetable material. Then, SC‐CO2 processing of this solid extract was performed operating at 0.8 kg h−1 SC‐CO2 flow rate and at different operative parameters. Very selective conditions were found operating at 90 bar and 50°C, obtaining a final product containing more than 71% w/w of active compounds (artemisinin, artemisin and dehydroartemisinin). CONCLUSION Using this approach, a product more than 2.6 times richer in artemisinin than the one obtained by conventional techniques and about 2 times richer than direct CO2 extraction, was obtained. Another relevant result is that the overall process scheme is cheaper than direct CO2 extraction, since a high pressure extractor about 20 times smaller can be used, to process the waxy product obtained by hexane extraction. © 2018 Society of Chemical Industry

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Chemical profile, antimicrobial potential, and antiaggregant activity of supercritical fluid extract from Agaricus bisporus

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Supercritical Extraction and Separation of Antioxidants from Residues of the Wine Industry

Cited by 7 publications

References 5 publications

Supercritical Antisolvent Technique for the Production of Breathable Naringin Powder

Supercritical Antisolvent Technique for the Production of Breathable Naringin Powder

Artemisia annua organic solvent extract, processed by supercritical CO₂

Chemical profile, antimicrobial potential, and antiaggregant activity of supercritical fluid extract from Agaricus bisporus

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Supercritical Extraction and Separation of Antioxidants from Residues of the Wine Industry

Cited by 7 publications

References 5 publications

Supercritical Antisolvent Technique for the Production of Breathable Naringin Powder

Supercritical Antisolvent Technique for the Production of Breathable Naringin Powder

Artemisia annua organic solvent extract, processed by supercritical CO2

Chemical profile, antimicrobial potential, and antiaggregant activity of supercritical fluid extract from Agaricus bisporus

Contact Info

Product

Resources

About

Artemisia annua organic solvent extract, processed by supercritical CO₂