Supercritical CO2 fluid-assisted cross-linking of porcine acellular dermal matrix by ethylene glycol diglycidyl ether

Dan, Nianhua; Dan, Weihua; Yu, Guofei

doi:10.1016/j.jcou.2018.03.017

Cited by 19 publications

(19 citation statements)

References 39 publications

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“…55,56 Overall, the cross-linked membranes had lower WU values and λ value than the pristine membranes due to the suppressed molecular motion and the dilution effect of the cross-linker. The relevant properties of Nafion 212 membrane were tested for comparison.…”

Section: Iec Values Water-uptake Values and Swelling Ratiosmentioning

confidence: 98%

“…The flexible and hydrophilic cross-linker EGDE ensured that the cross-linked membrane maintained a high WU value. 55,56 Overall, the cross-linked membranes had lower WU values and λ value than the pristine membranes due to the suppressed molecular motion and the dilution effect of the cross-linker. The SPI-B membrane absorbed more water than SPI-L, which was attributed to its unique branched molecular structure.…”

Section: Iec Values Water-uptake Values and Swelling Ratiosmentioning

confidence: 98%

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Cross‐linked polymer electrolyte membrane based on a highly branched sulfonated polyimide with improved electrochemical properties for fuel cell applications

Zhang

Chen

et al. 2019

Int J Energy Res

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Summary Sulfonated polyimides (SPIs) are extremely suitable as polymer electrolyte membranes (PEMs) for fuel cell applications, except for their poor water stability. Cross‐linking is a method that is commonly used to improve the weak hydrolytic stability of SPI membranes. However, this strategy significantly decreases the proton conductivity of the membrane, which leads to a lower fuel cell power density. In this work, a cross‐linked SPI membrane containing a highly branched polymer main chain was fabricated as a PEM. With a similar ion‐exchange capacity value, the cross‐linked membrane containing branched main chains showed an improved proton conductivity. Also, this membrane remained 92.3% of pristine weight after a hydrolytic stability test about 120 hours. In a single direct methanol fuel cell, the cross‐linked membrane containing a branched structure showed a higher power density (53.4 mW cm−2) than the common cross‐linked membrane (43.0 mW cm−2), indicating that branching is effective for improving the electrochemical properties of PEM‐based cross‐linked SPIs.

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Section: Iec Values Water-uptake Values and Swelling Ratiosmentioning

confidence: 98%

Section: Iec Values Water-uptake Values and Swelling Ratiosmentioning

confidence: 98%

Cross‐linked polymer electrolyte membrane based on a highly branched sulfonated polyimide with improved electrochemical properties for fuel cell applications

Zhang

Chen

et al. 2019

Int J Energy Res

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“…However, the current PADM has critical defects . For instance, the retained compact 3D network structure of the porcine skin has poor elasticity and flexibility . Thus, additional drilling is required to compensate for this lack of natural interconnected pores, which limits its ability as a true skin substitute.…”

Section: Introductionmentioning

confidence: 99%

Biogenetic Acellular Dermal Matrix Maintaining Rich Interconnected Microchannels for Accelerated Tissue Amendment

Wang

et al. 2021

ACS Appl. Mater. Interfaces

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Given that many people suffer from extensive skin damage, wound repair has drawn tremendous attention in research. Among the various assistant dressing materials that promote healing, a porcine acellular dermal matrix (PADM), as a skin substitute, can efficiently accelerate healing by promoting cell migration and proliferation. However, a simple, low-cost preparation process remains a challenge facing PADM development, particularly because of the inferior elasticity. To overcome these drawbacks, a CaCl2–ethanol–H2O solution (ternary solution) combined with an additional enzyme treatment was used to obtain a transparent, porous, and elastic PADM that retained the major extracellular matrix composition of the dermis. Our results indicated that alterations in the fiber organization and secondary structural changes in the collagen occurred after treatment. Furthermore, the in vivo wound healing and histological analyses clearly revealed an extremely expedited wound repair process following the application of the biocompatible PADM. In conclusion, this study provides new insights into the development of a transparent PADM with a porous structure and good elasticity that can be used as a skin substitute to accelerate the wound healing process. Moreover, this effective technique could potentially be used to extrapolate other decellularized materials in the future.

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“…Cross-linking modification is frequently used to improve the physicochemical properties of pADM. − However, it causes several side effects sometimes. For example, common chemical cross-linking may introduce impurities, which might lead to decreased biocompatibility and even cytotoxicity .…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Antibacterial Porcine Acellular Dermal Matrices with High Performance

Wang

Gong

et al. 2020

ACS Omega

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Infection is a common complication in the process of wound management. An ideal wound dressing is supposed to reduce or even prevent the infection while promoting wound healing. A porcine acellular dermal matrix (pADM) has been already used as a wound dressing in clinic due to its capacity to accelerate wound healing. However, not only is pure pADM not antibacterial, its mechanical properties are poor. In this study, an antibacterial pADM with good performance was prepared by adding two natural products as modifiers, quercetin (QCT) and tea tree oil (TTO). The result of Fourier-transform infrared (FTIR) proved that the addition of modifiers did not break the natural triple-helical structure of collagen. Meanwhile, the results of differential scanning calorimetry (DSC), thermogravimetric analysis (TG), mechanic experiment, and enzymatic degradation demonstrated that pADM handled with QCT and TTO (termed QCT–TTO–pADM) had better thermal stability, mechanical strength, and resistance to enzymatic degradation than pADM. Meanwhile, QCT–TTO–pADM had excellent antibacterial activity and showed an antibacterial rate of over 80%. Furthermore, in the cytocompatibility analysis, QCT–TTO–pADM had no side effects on the adhesion, growth, and proliferation of fibroblasts. QCT–TTO–pADM could even accelerate wound healing more efficiently than pADM and glutaraldehyde-modified pADM (GA-pADM). In conclusion, QCT–TTO–pADM was a potential antibacterial wound dressing with good performance.

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Supercritical CO2 fluid-assisted cross-linking of porcine acellular dermal matrix by ethylene glycol diglycidyl ether

Cited by 19 publications

References 39 publications

Cross‐linked polymer electrolyte membrane based on a highly branched sulfonated polyimide with improved electrochemical properties for fuel cell applications

Cross‐linked polymer electrolyte membrane based on a highly branched sulfonated polyimide with improved electrochemical properties for fuel cell applications

Biogenetic Acellular Dermal Matrix Maintaining Rich Interconnected Microchannels for Accelerated Tissue Amendment

Preparation and Characterization of Antibacterial Porcine Acellular Dermal Matrices with High Performance

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