Supercritical CO2-assisted impregnation of polylactic acid films with R-carvone: Effect of processing on loading, mass transfer kinetics, and final properties

Miranda-Villa, Patricia P.; Gañán, Nicolás Alberto; Martini, Raquel E.; Goñi, María L.

doi:10.1016/j.jcou.2022.102029

Cited by 10 publications

(6 citation statements)

References 58 publications

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“…The same trend had been revealed by both impregnation configurations in a previous work [11]. In addition, the results are in agreement with that obtained by other authors in the supercritical impregnation of carvone from PLA films [23]. In this study, a straight trend is obtained in the first instants of the release, and the slope becomes less pronounced when the density of the supercritical carbon dioxide is increased.…”

Section: Supercritical Impregnation (Sci)supporting

confidence: 92%

Supercritical Impregnation of Mango Leaf Extract into PLA 3D-Printed Devices and Evaluation of Their Biocompatibility with Endothelial Cell Cultures

et al. 2022

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The addition of natural substances with pharmacoactive properties to polymeric biomedical devices would provide beneficial regarding the assimilation of these endoprostheses when implanted into a patient’s body. The added drug would facilitate endothelization by regulating the inflammatory processes that such interventions entail, preventing contamination hazards and favoring the angiogenesis or formation of blood vessels in the tissue. The present work used mango leaf extract (MLE) obtained through pressurized ethanol for this purpose. Polylactic acid (PLA) in the form of filaments or 3D-printed disks was impregnated by means of supercritical technology with MLE for the culture essays. The release kinetics has been studied and the polymer matrices have been examined by scanning electron microscopy (SEM). The impregnated devices were subjected to in vitro culture of colony-forming endothelial cells. The influence of the different impregnation conditions used for the production of the MLE impregnated polymeric devices on the development of the cell culture was determined by fluorescence microscopy. The best results were obtained from the calcein cultures on 35 °C MLE impregnated into 3D-printed polymer disks.

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Section: Supercritical Impregnation (Sci)supporting

confidence: 92%

Supercritical Impregnation of Mango Leaf Extract into PLA 3D-Printed Devices and Evaluation of Their Biocompatibility with Endothelial Cell Cultures

et al. 2022

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“…Usually, an increase in soaking time increases the BC loading into the PLA matrix [ 15 , 75 , 125 , 139 ]. Kuska et al [ 15 ] reported an increase in thymol loading into PLA beads from 11.0 to 19.8% at 20 MPa and 120 °C by prolongation of the process from 2 to 24 h. This BC acted as a molecular lubricant, which resulted in the increased free volume of the PLA matrix and consequently in the higher sorption of a supercritical solution.…”

Section: Pla Impregnation With Bioactive Components Using Sc-comentioning

confidence: 99%

“…These active materials are the driving force for innovation, as PLA is minimally processed in an environmentally friendly manner, and it can extend food shelf life, enhance food safety and/or sensory properties, and contribute to the preservation of food quality [ 58 , 126 , 127 ]. In addition, these materials can be recycled or they can degrade in the environment after disposal [ 139 ]. Villegas et al [ 127 ] demonstrated that PLA films impregnated with thymol and cinnamaldehyde are active against Escherichia coli and Staphylococcus aureus and could be potentially used for food packaging.…”

Section: Pla Impregnation With Bioactive Components Using Sc-comentioning

confidence: 99%

Green Processing of Neat Poly(lactic acid) Using Carbon Dioxide under Elevated Pressure for Preparation of Advanced Materials: A Review (2012–2022)

et al. 2023

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This review provides a concise overview of up-to-date developments in the processing of neat poly(lactic acid) (PLA), improvement in its properties, and preparation of advanced materials using a green medium (CO2 under elevated pressure). Pressurized CO2 in the dense and supercritical state is a superior alternative medium to organic solvents, as it is easily available, fully recyclable, has easily tunable properties, and can be completely removed from the final material without post-processing steps. This review summarizes the state of the art on PLA drying, impregnation, foaming, and particle generation by the employment of dense and supercritical CO2 for the development of new materials. An analysis of the effect of processing methods on the final material properties was focused on neat PLA and PLA with an addition of natural bioactive components. It was demonstrated that CO2-assisted processes enable the control of PLA properties, reduce operating times, and require less energy compared to conventional ones. The described environmentally friendly processing techniques and the versatility of PLA were employed for the preparation of foams, aerogels, scaffolds, microparticles, and nanoparticles, as well as bioactive materials. These PLA-based materials can find application in tissue engineering, drug delivery, active food packaging, compostable packaging, wastewater treatment, or thermal insulation, among others.

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“…10,11 Sc-CO 2 is also the best foaming agent for products requiring a high expansion ratio due to its high diffusion and solubility in the polymer matrix. [12][13][14][15][16] PLA bears a terminal carboxyl group, which reacts relatively fast with an epoxy group in the molten state. 17 Thus, the use of a multi-epoxy compound can be used as a CE to increase the melt strength of PLA and consequently improve its foamability.…”

Section: Introductionmentioning

confidence: 99%

Effect of nano‐sized zinc citrate on the supercritical carbon dioxide‐assisted extrusion foaming behavior of poly(lactic acid)

Zhou

Liu

Yin

et al. 2023

J of Applied Polymer Sci

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Poly(lactic acid) (PLA) foams containing various amounts of an epoxy as a chain extender (CE) and nano‐sized zinc citrate as a nucleating agent are prepared by continuous extrusion using supercritical CO2 (sc‐CO2) as a physical foaming agent. Processing parameters such as the CE content, sc‐CO2 flow rate, and foaming temperature are optimized with regard to the apparent density and expansion ratio of the PLA foams. The nano‐sized zinc citrate exhibits a high nucleation activity for the crystallization of the PLA. The addition of 0.5 wt% nano‐sized zinc citrate significantly increases the compressive strength and modulus of the PLA foams from 0.124 MPa and 3.1 MPa to 0.35 MPa and 19 MPa, respectively. The PLA/0.5 wt% nano‐sized zinc citrate foam shows a microcellular structure with an average cell diameter of 17.1 μm.

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Supercritical CO2-assisted impregnation of polylactic acid films with R-carvone: Effect of processing on loading, mass transfer kinetics, and final properties

Cited by 10 publications

References 58 publications

Supercritical Impregnation of Mango Leaf Extract into PLA 3D-Printed Devices and Evaluation of Their Biocompatibility with Endothelial Cell Cultures

Supercritical Impregnation of Mango Leaf Extract into PLA 3D-Printed Devices and Evaluation of Their Biocompatibility with Endothelial Cell Cultures

Green Processing of Neat Poly(lactic acid) Using Carbon Dioxide under Elevated Pressure for Preparation of Advanced Materials: A Review (2012–2022)

Effect of nano‐sized zinc citrate on the supercritical carbon dioxide‐assisted extrusion foaming behavior of poly(lactic acid)

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