Supercritical carbon dioxide extraction of glycyrrhizic acid from licorice plant root using binary entrainer: Experimental optimization via response surface methodology

Hedayati, Ali; Ghoreishi, S.M.

doi:10.1016/j.supflu.2015.03.005

Cited by 50 publications

(20 citation statements)

References 36 publications

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“…The extraction of glycyrrhizic acid from licorice by the conventional liquid–liquid extraction technique is characterized by several disadvantages, such as high extraction times and temperatures, large solvent requirements, and low yields. Macroporous resins [8], ultrasound-estraction [9], microwave-assisted extraction [10], supercritical CO 2 extraction [11], high-speed [12], and pH-zone-refining counter-current chromatography [13] have also been adopted. However, most of these procedures involve a number of steps and large amounts of solvent/chemicals; additional disadvantages include poor recovery (from 20% to 30%) and high process costs.…”

Section: Introductionmentioning

confidence: 99%

A Membrane-Based Process for the Recovery of Glycyrrhizin and Phenolic Compounds from Licorice Wastewaters

et al. 2019

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In this work, the use of polymeric ultrafiltration and nanofiltration membranes was investigated in order to recover glycyrrhizin and phenolic compounds from licorice wastewaters. Filtration experiments were performed on a laboratory scale using four polyamide thin-film composite membranes (GK, GH, GE, and DK, from GE Osmonics) with different molecular weight cut-offs (from 150 to 3500 Da). The permeate flux and retention values of glycyrrhizin, the total polyphenols, the caffeic acid, the total carbohydrate, and the total antioxidant activity as a function of the transmembrane pressure (TMP) and weight reduction factor (WRF) were evaluated. In selected operating conditions, the membrane productivity decreased in the order of GK > DK > GH > GE, with a similar trend to that of water permeability. Glycyrrhizin was totally rejected by selected membranes, independently of TMP and WRF. For the other antioxidant compounds, the retention values increased by increasing both of the parameters. According to the experimental results, a combination of membranes in a sequential design was proposed as a viable approach to produce concentrated fractions enriched in bioactive compounds and purified water from licorice wastewater.

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Section: Introductionmentioning

confidence: 99%

A Membrane-Based Process for the Recovery of Glycyrrhizin and Phenolic Compounds from Licorice Wastewaters

et al. 2019

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“…Recently, Hedayati and Ghoreishi () evaluated the effect of different process parameters on the recovery of glycyrrhizin from licorice. Their results showed that increasing pressure favored the recovery of glycyrrhizin while the solubility and extraction of glycyrrhizin increased as a function of density.…”

Section: Resultsmentioning

confidence: 99%

Investigating the antioxidant potential of licorice extracts obtained through different extraction modes

et al. 2017

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In the current study, antioxidant potential of licorice extracts was determined through different assays. For optimum recovery of bioactive components, three solvents (ethanol, methanol, and ethyl acetate) were employed at different ratios with water (25:75, 50:50, and 75:25) and supercritical fluid extracts (SFE) were obtained at varying pressures (3,500, 4,500, and 5,500 psi).Results exhibited that the extraction of antioxidant compounds from licorice increased with increasing solvent concentration. Among solvent extracts, 75% ethanolic extract showed highest total phenolic content (TPC), total flavonoids content (TF), and antioxidant activity. The supercritical CO 2 extract obtained at 5,500 psi pressure exhibited highest values for TPC, TF, and antioxidant capacity. It was evident from HPLC analysis that the highest recovery of major bioactive components (glycyrrhizin and glabridin) was obtained through supercritical CO 2 extraction at elevated pressures. Practical applicationsLicorice is a rich source of biologically active components with history of medicinal use. The current study provides an approach to maximize the recovery of desired components from licorice that can be used in different formulations with antioxidant potential. K E Y W O R D S antioxidant activity, licorice, phytochemical content, solvent extraction, supercritical CO 2 extraction

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“…The objective is to understand the interaction among various parameters and the optimization of the operating conditions to obtain the best response, simultaneously 19 . RSM is a useful tool which has been widely applied successfully in several fields for the optimization of operating parameters in various processes [20][21][22] .…”

Section: Fig 4: the Flow Sheet Of The Electrothermal Fluidized Bed Cmentioning

confidence: 99%

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2017

IJPSR

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Zirconium tetrachloride was produced in a pilot plant fluidized bed reactor via the carbochlorination reaction of zirconia. Minitab software 17 was used for the design of experiment with response surface methodology (RSM) for both semi batch and continuous processes. The operating temperature (800-1200 °C), reaction time (30-90 min) and mean particle size (MPS) (70-130µm) were chosen as the range of operating conditions at semi-batch mode. Also, the ranges of operating variables at the continuous mode were chosen to be the operating temperature(1000-1400°C), chlorine concentration (3-5mol/m 3 ) and mean particle size (MPS) (70-130µm). The coefficients of determination (R 2 ) for semi-batch and continuous modes by RSM analysis were 99.54% and 99.94%, respectively. The optimal operating conditions was predicted to be the Cl 2 concentration of 3mol/m 3 , temperature of 1380 °C and the mean particle size of 70µm in which the maximum chlorine conversion of 98.26% was obtained at continuous process. The optimum operating conditions for semi-batch process were found by using RSM modelling to be 1200°C, 90 min and 70 µm, in which the maximum zirconia conversion of 92.7% was obtained.

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Supercritical carbon dioxide extraction of glycyrrhizic acid from licorice plant root using binary entrainer: Experimental optimization via response surface methodology

Cited by 50 publications

References 36 publications

A Membrane-Based Process for the Recovery of Glycyrrhizin and Phenolic Compounds from Licorice Wastewaters

A Membrane-Based Process for the Recovery of Glycyrrhizin and Phenolic Compounds from Licorice Wastewaters

Investigating the antioxidant potential of licorice extracts obtained through different extraction modes

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