Supercritical carbon dioxide-based technologies for the production of drug nanoparticles/nanocrystals – A comprehensive review

Padrela, Luís; Rodrigues, Miguel A.; Duarte, Andreia; Dias, Ana M.A.; Braga, Mara E.M.; Sousa, Hermínio C. de

doi:10.1016/j.addr.2018.07.010

Cited by 179 publications

(87 citation statements)

References 635 publications

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“…Further concerns exist on the potential loss of bioactivity and molecular integrity due to severe thermogenesis derived from the milling process. Other disadvantages for the top-down methods are: The lack of complete control of the morphology and crystallinity of the final product; particle aggregation/agglomeration issues; losses of the product due to drug adherence to equipment surfaces and residual presence of surfactants, solvents or stabilizers (Padrela et al, 2018).…”

Section: Nanocrystalsmentioning

confidence: 99%

“…Another approach to producing drug nanocrystals is based on supercritical carbon dioxide (ssCO 2 ). The details on the roles of ssCO 2 as solvent, co-solvent and as an additive for the production of drug nanocrystals are comprehensively reviewed elsewhere (Padrela et al, 2018). Amongst the main disadvantages of the bottom-up methods to produce drug nano-crystals are: (i) the difficulty to control the particle size, nucleation, and growth of crystals that may lead to both, undesired morphologies or amorphous crystallinities and subsequent particle agglomeration; (ii) the need for large amounts of organic solvents; (iii) finetuning solvent/antisolvent formulation is time-consuming; (iv) need for solvent removal; (v) labile drugs may denature during heating solvent removal; (vi) need for specialized equipment for ssCO 2 -based nanocrystals (Padrela et al, 2018).…”

Section: Nanocrystalsmentioning

confidence: 99%

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Nanoscale Drug Delivery Systems: From Medicine to Agriculture

Vega-Vásquez

Mosier

Irudayaraj

2020

Front. Bioeng. Biotechnol.

177

107

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The main challenges in drug delivery systems are to protect, transport and release biologically active compounds at the right time in a safe and reproducible manner, usually at a specific target site. In the past, drug nano-carriers have contributed to the development of precision medicine and to a lesser extent have focused on its inroads in agriculture. The concept of engineered nano-carriers may be a promising route to address confounding challenges in agriculture that could perhaps lead to an increase in crop production while reducing the environmental impact associated with crop protection and food production. The main objective of this review is to contrast the advantages and disadvantages of different types of nanoparticles and nano-carriers currently used in the biomedical field along with their fabrication methods to discuss the potential use of these technologies at a larger scale in agriculture. Here we explain what is the problem that nano-delivery systems intent to solve as a technological platform and describe the benefits this technology has brought to medicine. Also here we highlight the potential drawbacks that this technology may face during its translation to agricultural applications, based on the lessons learned so far from its use for biomedical purposes. We discuss not only the characteristics of an ideal nano-delivery system, but also the potential constraints regarding the fabrication including technical, environmental, and legal aspects. A key motivation is to evaluate the potential use of these systems in agriculture, especially in the area of plant breeding, growth promotion, disease control, and post-harvest quality control. Further, we highlight the importance of a rational design of nano-carriers and identify current research gaps to enable scale-up relevant to applications in the treatment of plant diseases, controlled release of fertilizers, and plant breeding.

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Section: Nanocrystalsmentioning

confidence: 99%

Section: Nanocrystalsmentioning

confidence: 99%

Nanoscale Drug Delivery Systems: From Medicine to Agriculture

Vega-Vásquez

Mosier

Irudayaraj

2020

Front. Bioeng. Biotechnol.

177

107

View full text Add to dashboard Cite

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“…The rapid expansion of the solution into an ambient environment results in the generation of nanoparticles. This method was first developed for inorganic particles before being used with pre-formed polymeric materials (Al-Kassas R. et al, 2017;Anton N. et al, 2008;Padrela L. et al, 2018;Williams H.D. et al, 2013).…”

Section: Methods Of Nanoparticle Manufacturementioning

confidence: 99%

Nanoparticle Technology for Respiratory Tract Mucosal Vaccine Delivery

Johnson

Mecham

Quinn

et al. 2020

KONA

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Immunization can be traced back to classical China. Modern immunization reduces the risk of infection by attenuating or killing the pathogen or using non-infectious antigens to elicit the immune response. The challenge of immunization is to raise a robust protective response without infecting the individual or overstimulating the immune response, and this can be achieved by using nanoparticle delivery systems to specifically target the innate immune system with known antigens and where necessary include an adjuvant to enhance the efficacy. These systems can be targeted to mucosal sites that are located throughout the body with the nasal and pulmonary routes of administration allowing ease of access. Macrophages are the first line of defense of the innate immune system and are the host cell for primary intracellular infection by several respiratory pathogens notably mycobacteria and streptococci. The breadth of nanoparticle technology available to deliver vaccines has been explored and consideration of its value in nasal and pulmonary delivery is addressed specifically.

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“…Compared to other physical foaming agents, carbon dioxide presents unique advantages mainly related to its safety properties (low toxicity and flammability), recyclability, and sustainability being considered a green technology [94]. The morphology of the polymer (crystalline or amorphous) determines the free volume available for the CO 2 to absorb in the polymers, affecting both the solubility and diffusivity values in the matrix [95].…”

Section: Compressed Co 2 and Supercritical Co 2 -Assisted Foamingmentioning

confidence: 99%

Solvent-Free Approaches for the Processing of Scaffolds in Regenerative Medicine

2020

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The regenerative medicine field is seeking novel strategies for the production of synthetic scaffolds that are able to promote the in vivo regeneration of a fully functional tissue. The choices of the scaffold formulation and the manufacturing method are crucial to determine the rate of success of the graft for the intended tissue regeneration process. On one hand, the incorporation of bioactive compounds such as growth factors and drugs in the scaffolds can efficiently guide and promote the spreading, differentiation, growth, and proliferation of cells as well as alleviate post-surgical complications such as foreign body responses and infections. On the other hand, the manufacturing method will determine the feasible morphological properties of the scaffolds and, in certain cases, it can compromise their biocompatibility. In the case of medicated scaffolds, the manufacturing method has also a key effect in the incorporation yield and retained activity of the loaded bioactive agents. In this work, solvent-free methods for scaffolds production, i.e., technological approaches leading to the processing of the porous material with no use of solvents, are presented as advantageous solutions for the processing of medicated scaffolds in terms of efficiency and versatility. The principles of these solvent-free technologies (melt molding, 3D printing by fused deposition modeling, sintering of solid microspheres, gas foaming, and compressed CO2 and supercritical CO2-assisted foaming), a critical discussion of advantages and limitations, as well as selected examples for regenerative medicine purposes are herein presented.

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Supercritical carbon dioxide-based technologies for the production of drug nanoparticles/nanocrystals – A comprehensive review

Cited by 179 publications

References 635 publications

Nanoscale Drug Delivery Systems: From Medicine to Agriculture

Nanoscale Drug Delivery Systems: From Medicine to Agriculture

Nanoparticle Technology for Respiratory Tract Mucosal Vaccine Delivery

Solvent-Free Approaches for the Processing of Scaffolds in Regenerative Medicine

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