Supercritical antisolvent micronization of some biopolymers

Reverchon, Ernesto; Porta, Giovanna Della; Rosa, Igor M. De; Subra, P.; Letourneur, Didier

doi:10.1016/s0896-8446(00)00069-3

Cited by 120 publications

(63 citation statements)

References 14 publications

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“…However, the drug loading might depend more on the type of system such as the crystallization/precipitation behavior of both the drug and the polymer. Kim et al (2006) investigated precipitation of L-PLA by SAS process and indicated that the ratio (R) of anti-solvent flow rate CO 2 (l/min)/the L-PLA/methylene chloride solution flow rate (ml/min) was an important factor for fine L-PLA particles (22). It was found that the L-PLA particle size was decreased when increasing R ratio.…”

Section: Resultsmentioning

confidence: 99%

“…Various supercritical fluid techniques have been used as methods for preparation of microparticles of pure biodegradable polymers, e.g., poly-(DL-lactide), poly(L-lactide), poly-(DL-lactide-co-glycolyde) (PGLA), poly(β-hydroxybutyric acid), dextran, inulin (19)(20)(21)(22), and pure drugs, e.g., rifampicin, cepharosporin, and tetracycline (23)(24)(25). Bahrami and Ranjbarian (2007) and Tandya et al (2007) have reviewed the application of SCF techniques to fabricate polymeric drugloaded formulations (11,26).…”

Section: Introductionmentioning

confidence: 99%

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Formation of Inhalable Rifampicin–Poly(l-lactide) Microparticles by Supercritical Anti-solvent Process

2008

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Abstract. Formation of inhalable microparticles containing rifampicin and poly(L-lactide) (L-PLA) by using supercritical anti-solvent process (SAS) was investigated. The solutions of drug and polymer in methylene chloride were sprayed into supercritical carbon dioxide. The effect of polymer content and operating conditions, temperature, pressure, carbon dioxide molar fraction, and concentration of solution, on product characteristics were studied. The prepared microparticles were characterized with respect to their morphology, particle size and size distribution, drug content, drug loading efficiency, and drug release characteristic. Discrete, spherical microparticles were obtained at high polymer:drug ratios of 7:3, 8:2, and 9:1. The shape of L-PLA microparticles became more irregular and agglomerated with decreasing polymer content. Microparticles with polymer content higher than 60% exhibited volumetric mean diameter less than 5 μm, but percent drug loading efficiency was relatively low. Drug-loaded microparticles containing 70% and 80% L-PLA showed a sustainable drug release property without initial burst release. Operating temperature level influenced on mean size and size distribution of microparticles. The operating pressure and carbon dioxide molar fraction in the range investigated were unlikely to have an effect on microparticle formation. An increasing concentration of feed solution provided larger size microparticles. Rifampicin-loaded L-PLA microparticles could be produced by SAS in a size range suitable for dry powder inhaler formulation.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Formation of Inhalable Rifampicin–Poly(l-lactide) Microparticles by Supercritical Anti-solvent Process

2008

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“…[10][11][12] Although, sc-CO 2 is considered to be a favorite solvent in SCF processes due to its low critical parameters, however, it is not a good solvent for dissolving polar biodegradable polymers. [13][14][15] It requires an additional organic solvent 16 which must be completely removed for biomedical applications.…”

Section: 4mentioning

confidence: 99%

A Faster Approach to Stereocomplex Formation of High Molecular Weight Polylactide Using Supercritical Dimethyl Ether

Bibi¹,

Jung²,

Lim³

et al. 2015

Polymer Korea

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Engineering the polylactide via stereocomplexation with supercritical fluid (SCF) technology paved way to fabricate polymers with enhanced thermal and mechanical properties. We aimed to establish a SCF medium with excellent solubility for PLA without any additional solvent/co-solvent. We, therefore, employed supercritical dimethyl ether to synthesize 100% stereocomplex polylactide from high molecular weight homopolymers with an excellent yield. The remarkable solubility of the homopolymers in dimethyl ether is the key for quick conversion to s-PLA. This study proves a rapid synthesis route of dry s-PLA powder with sc-DME at 250 bar, 70 o C and 1.5 h, which are reasonably achievable processing parameters compared to the conventional methods. The degree of stereocomplexation was evaluated under the effect of pressures, temperatures, times, homopolymer-concentrations and molecular weights. An increment in the degree of stereocomplexation was observed with increased temperature and pressure. Complete conversion to s-PLA was obtained for PLLA and PDLA with M n~2 00 kg·mol -1 with a total homopolymer to total DME ratio of 6:100% w/w at prescribed reaction conditions. The degree of stereocomplexation was determined by DSC and confirmed by XRD. Considerable improvement in thermo-mechanical properties of s-PLA was observed. DSC and TGA analyses proved a 50 o C enhancement in melting transition and a high onset temperature for thermal degradation of s-PLA respectively.

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“…Some modified SAS processes have been developed based on the mixing style of SF with solutions like aerosol solvent extraction systems, SAS with enhanced mass transfer, and solution-enhanced dispersion by supercritical fluids (SEDS). [3][4][5][6][7][8] The key unit of the SEDS process is a special coaxial nozzle via which the SF and the liquid solution are injected into a high-pressure vessel simultaneously. In this way the SF acts both as an antisolvent and as a "spray enhancer" through hydro mechanical effects.…”

Section: Introductionmentioning

confidence: 99%

Preparation of zein nanoparticles by using solution-enhanced dispersion with supercritical CO<sub>2</sub> and elucidation with computational fluid dynamics

Li¹,

Zhao²

2017

IJN

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Nanoparticles have attracted more and more attention in the medicinal field. Zein is a biomacromolecule and can be used as a carrier for delivering active ingredients to prepare controlled release drugs. In this article, we presented the preparation of zein nanoparticles by solution-enhanced dispersion by supercritical CO 2 (SEDS) approach. Scanning electron microscopy and transmission electron microscopy were applied to characterize the size and morphology of the obtained particles. The nozzle structure and the CO 2 flow rate greatly affected the morphology and the size of the particles. The size of zein was able to be reduced to 50–350 nm according to the different conditions. The morphologies of the resultant zein were either sphere or the filament network consisted of nanoparticles. The influence of the nozzle structure and the CO 2 flow rate on the velocity field was elucidated by using computational fluid dynamics. The nozzle structure and the CO 2 flow rate greatly affected the distribution of the velocity field. However, a similar velocity field could also be obtained when the nozzle structure or the CO 2 flow rate, or both were different. Therefore, the influence of the nozzle structure and the CO 2 flow rate on the size and morphology of the particles, can boil down to the velocity field. The results demonstrated that the velocity field can be a potential criterion for producing nanoparticles with controllable morphology and size, which is useful to scale-up the SEDS process.

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Supercritical antisolvent micronization of some biopolymers

Cited by 120 publications

References 14 publications

Formation of Inhalable Rifampicin–Poly(l-lactide) Microparticles by Supercritical Anti-solvent Process

Formation of Inhalable Rifampicin–Poly(l-lactide) Microparticles by Supercritical Anti-solvent Process

A Faster Approach to Stereocomplex Formation of High Molecular Weight Polylactide Using Supercritical Dimethyl Ether

Preparation of zein nanoparticles by using solution-enhanced dispersion with supercritical CO<sub>2</sub> and elucidation with computational fluid dynamics

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