Supercritical antisolvent micronization of minocycline hydrochloride

Cardoso, M.A. Tavares; Monteiro, Gabriel A.; Cardoso, José Luís; Prazeres, Telmo J. V.; Figueiredo, J.M.; Martinho, J. M. G.; Cabral, Joaquim M. S.; Palavra, A. M. F.

doi:10.1016/j.supflu.2007.09.035

Cited by 43 publications

(11 citation statements)

References 42 publications

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“…This effect is mainly due to the reduction of the surface tension of the expanded liquid, obtained by increasing the temperature. Lower surface tension of the expanded liquid ( Cardoso et al, 2008 ) results in an improvement in the mixing with the antisolvent, which consequently produces smaller particles. In summary, the increase in temperature favours supersaturation and, therefore, a faster precipitation process.…”

Section: Resultsmentioning

confidence: 99%

Antioxidants entrapment in polycaprolactone microparticles using supercritical assisted injection in a liquid antisolvent

Palazzo

Campardelli

Reverchon

2020

Food and Bioproducts Processing

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Section: Resultsmentioning

confidence: 99%

Antioxidants entrapment in polycaprolactone microparticles using supercritical assisted injection in a liquid antisolvent

Palazzo

Campardelli

Reverchon

2020

Food and Bioproducts Processing

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“…For these purposes, the SAS technique is one of the most effective micronization techniques based on the use of supercritical CO 2 . Up to now, several active compounds, such as antibiotics [25,[58][59][60][61][62][63][64], NSAIDs [46,65], antioxidant compounds [1,6,7,38,66], anticancer drugs [3,4,[67][68][69], and others [2,32,[70][71][72], were micronized in the form of nanoparticles, sub-microparticles, and microparticles using the SAS process.…”

Section: Sas Micronization Of Active Compoundsmentioning

confidence: 99%

Supercritical Antisolvent Process for Pharmaceutical Applications: A Review

Franco

Marco

2020

Processes

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The supercritical antisolvent (SAS) technique has been widely employed in the biomedical field, including drug delivery, to obtain drug particles or polymer-based systems of nanometric or micrometric size. The primary purpose of producing SAS particles is to improve the treatment of different pathologies and to better the patient’s compliance. In this context, many active compounds have been micronized to enhance their dissolution rate and bioavailability. Aiming for more effective treatments with reduced side effects caused by drug overdose, the SAS polymer/active principle coprecipitation has mainly been proposed to offer an adequate drug release for specific therapy. The demand for new formulations with reduced side effects on the patient’s health is still growing; in this context, the SAS technique is a promising tool to solve existing issues in the biomedical field. This updated review on the use of the SAS process for clinical applications provides useful information about the achievements, the most effective polymeric carriers, and parameters, as well as future perspectives.

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“…Other works also carried out a complete modelling. In these cases, the overall process is modelled, taking into account thermodynamic, hydrodynamic, crystallization and mass transfer aspects (Cardoso et al, 2008;Martin & Cocero, 2004;Lora et al, 2000;Reverchon et al, 2010). At the University of Cádiz, Tenorio et al, by determining the thermodynamic properties of the phases involved in the process, and applying empirical equations (operations with dimensionless numbers), have estimated the different disintegration regimes of the jet when an N-methyl-pyrrolidone (NMP)-ampicillin solution was injected into the CO 2 -pressurized chamber.…”

Section: Sas Process 41 Mass Transfermentioning

confidence: 99%