Supercritical antisolvent fractionation of antioxidant compounds from Lavandula luisieri (Rozeira) Riv.-Mart.

Giménez-Rota, Carlota; Langa, Elisa; Urieta, José S.; Hernáiz, María J.; Mainar, Ana M.

doi:10.1016/j.supflu.2020.104821

Cited by 8 publications

(5 citation statements)

References 37 publications

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“…The pre-treated material, previously ground and sieved, was defatted in a first stage to facilitate the obtaining of the antioxidant fraction. This stage was usually carried out by means of maceration in hexane [ 41 , 45 ], but in a more recent study, supercritical extraction with CO 2 was used [ 51 ]. This is due to the advantages offered by this type of extraction; since it is a non-toxic solvent, its polarity facilitates the extraction of lipophilic compounds and generates solvent-free final products because it can be easily removed by lowering the pressure.…”

Section: Resultsmentioning

confidence: 99%

“…Regarding the extraction of C. officinalis , there have been numerous studies applying this technique to obtain compounds such as triterpenoid esters [ 37 ], triterpene triols [ 38 ], or its essential oil [ 39 , 40 ]. Another promising technique is supercritical antisolvent fractionation (SAF), which makes it possible to precipitate and concentrate bioactive compounds selectively from a solution, while the rest remain dissolved [ 41 ]. For this purpose, the solution is pumped and sprayed into a vessel, where it converges with sc-CO 2 in such a way that the insoluble compounds in this new mixture (solvent + sc-CO 2 ) precipitate, while the still soluble ones are collected in a second vessel as a dissolution.…”

Section: Introductionmentioning

confidence: 99%

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Concentration of Antioxidant Compounds from Calendula officinalis through Sustainable Supercritical Technologies, and Computational Study of Their Permeability in Skin for Cosmetic Use

et al. 2021

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The growing interest in the cosmetic industry in using compounds of natural and sustainable origin that are safe for humans is encouraging the development of processes that can satisfy these needs. Chlorogenic acid (CHA), caffeic acid (CAF) and ferulic acid (FA) are three compounds widely used within the cosmetic industry due to their functionalities as antioxidants, collagen modifiers or even as radiation protectors. In this work, two advanced separation techniques with supercritical CO2 are used to obtain these three compounds from Calendula officinalis, and these are then evaluated using a computational skin permeability model. This model is encompassed by the COSMO-RS model, the calculations of which make it possible to study the behaviour of the compounds in the epidermis. The results show that both CAF and FA are retained in the stratum corneum, while CHA manages to penetrate to the stratum spinosum. These compounds were concentrated by antisolvent fractionation with super-critical CO2 using a Response Surface Methodology to study the effect of pressure and CO2 flow rate. CHA, CAF and FA were completely retained in the precipitation vessel, with concentrations between 40% and 70% greater than in the original extract. The conditions predicted that the optimal overall yield and enrichment achieved would be 153 bar and 42 g/min.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Concentration of Antioxidant Compounds from Calendula officinalis through Sustainable Supercritical Technologies, and Computational Study of Their Permeability in Skin for Cosmetic Use

et al. 2021

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“…The chemical structure of ursolic acid (Figure 2) isolated from the methanol, ethanol, and methanol-dichloromethane (1 : 1, v/ v) extracts of L. stoechas was confirmed by 1 H and 13 C-NMR spectroscopy and by comparing the spectral data previously reported in the literature. [43] Previously, ursolic acid was reported some Lavandula species such as L. spica, [44] L. luisieri, [45][46][47] L. augustifolia, [48] L. latifolia, [49] L. multifidi [50] and L. pubescens. [51] The spectral data of ursolic acid are given below.…”

Section: Spectroscopic Data On Ursolic Acidmentioning

confidence: 99%

Lavandula stoechas L. subsp. stoechas, a New Herbal Source for Ursolic Acid: Quantitative Analysis, Purification and Bioactivity Studies

Aydin¹,

Kaya

Gümüştaş

et al. 2023

Chemistry & Biodiversity

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In this study, methanol, ethanol, methanol‐dichloromethane (1 : 1, v/v), acetone, ethyl acetate, diethyl ether, and chloroform extracts of lavender (Lavandula stoechas L. subsp. stoechas) were prepared by maceration, and the ursolic acid contents in the extracts were determined quantitatively by HPLC analyses. The present results show that the methanol‐dichloromethane (1 : 1, v/v) solvent system is the most efficient solvent system for the extraction of ursolic acid from the plant sample with the highest yield (2.22 g/100 g plant sample). In the present study, a new practical method for the isolation of ursolic acid from polar extracts was also demonstrated for the first time. The inhibition effects of the extracts and ursolic acid were also revealed on α‐glycosidase, acetylcholinesterase, butyrylcholinesterase, and human carbonic anhydrase I and II enzymes by determining IC50 values for the first time. The extracts and ursolic acid acted as potent antidiabetic agents by strongly inhibiting the α‐glycosidase activity, whereas they were found to be very weak neuroprotective agents. In view of the present results, L. stoechas and its major metabolite, ursolic acid, can be recommended as a herbal source to control postprandial blood sugar levels and prevent diabetes by delaying the digestion of starch in food.

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“…A prospective source of rich bioactive compounds, the Lamiaceae family, is a widespread plant family, comprising numerous medicinal and aromatic plants that provide an array of benefits for human health [8][9][10][11][12]. The Lavandula genus of the Lamiaceae family contains a multitude of different species with a vast geographical distribution, amongst which the L. angustifolia and L. latifolia species present the highest economic value [13].…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition and Biological Properties of New Romanian Lavandula Species

Marchidan,

Ortan,

Marcu Spinu

et al. 2023

Antioxidants

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The aims of the present study were to evaluate for the first time the chemical composition and antioxidant, antibacterial, antifungal and antiproliferative potentials of the Romanian George 90 lavender species, as well as parental species, L. angustifolia and L. latifolia. The L. angustifolia, L. latifolia and George 90 essential oils were analyzed by GC-MS/MS and the L. angustifolia, L. latifolia and George 90 hydroalcoholic extracts were analyzed by HPLC-DAD. The antioxidant, antibacterial, antifungal and antiproliferative assays revealed that all the investigated species showed significant activities. The results highlighted the chemical composition and the promising biological potentials of the L. angustifolia, L. latifolia and George 90 lavender species, validating their ethnomedicinal value, which offers potential applications as natural drugs.

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Supercritical antisolvent fractionation of antioxidant compounds from Lavandula luisieri (Rozeira) Riv.-Mart.

Cited by 8 publications

References 37 publications

Concentration of Antioxidant Compounds from Calendula officinalis through Sustainable Supercritical Technologies, and Computational Study of Their Permeability in Skin for Cosmetic Use

Concentration of Antioxidant Compounds from Calendula officinalis through Sustainable Supercritical Technologies, and Computational Study of Their Permeability in Skin for Cosmetic Use

Lavandula stoechas L. subsp. stoechas, a New Herbal Source for Ursolic Acid: Quantitative Analysis, Purification and Bioactivity Studies

Chemical Composition and Biological Properties of New Romanian Lavandula Species

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